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公开(公告)号：KR102201940B1
公开(公告)日：2021-01-12
申请号：KR1020190016452
申请日：2019-02-13
Applicant: 가톨릭관동대학교산학협력단
Abstract: 화학식 1로표시되는화합물또는이의약제학적으로허용가능한염을유효성분으로포함하는혈전관련질환및 혈액순환장애관련질환의예방또는치료용약학적조성물이개시된다. 상기화학식 1로표시되는화합물또는이의약제학적으로허용가능한염을유효성분으로포함하는조성물은혈소판응집효과가있어혈전관련질환및 혈액순환장애관련질환에효능이있다.
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公开(公告)号：KR102036304B1
公开(公告)日：2019-10-24
申请号：KR1020180040294
申请日：2018-04-06
Applicant: 가톨릭관동대학교산학협력단
IPC: C07C49/255 , A61K31/12 , A61P3/04
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4.发明公开모자반 추출물 또는 그 유효성분을 포함하는 혈소판응집 억제 효과를 이용한 혈전관련 질환 및 혈액순환장애 예방 및 치료제 无效使用SARGASSUM或其有效成分提取物的抗药效应预防和调节循环障碍或血栓相关疾病
公开(公告)号：KR1020130041544A
公开(公告)日：2013-04-25
申请号：KR1020110105863
申请日：2011-10-17
Applicant: 가톨릭관동대학교산학협력단
Abstract: PURPOSE: A preventive and therapeutic agent containing a Sargassum extract or an active ingredient thereof for thrombus-related diseases and circulatory disturbance is provided to effectively suppress platelet aggregation. CONSTITUTION: A method for preparing a Sargassum extract comprises: a step of dipping 1kg of Sargassum in 100% ethanol and extracting three times for 24 hours; a step of filtering the extract; and a step of completely evaporating the extract and concentrating by reduced pressure. 1g of the extract contains 61mg of sargaquinoic acid and 214mg of sargahydroquinoic acid. The extract prevents and treats thrombus-related diseases and improves blood circulation.
Abstract translation: 目的：提供含有血栓相关疾病和循环障碍的马齿苋提取物或其活性成分的预防和治疗剂，以有效抑制血小板聚集。 构成：制备马齿苋提取物的方法包括：将1kg马鞭草浸入100％乙醇中并提取三次24小时的步骤; 过滤提取物的步骤; 以及完全蒸发萃取物并通过减压浓缩的步骤。 1g的提取物含有61mg的夸喹酸和214mg的大夸喹酸。 提取物可预防和治疗血栓相关疾病，改善血液循环。
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公开(公告)号：KR101100624B1
公开(公告)日：2012-01-03
申请号：KR1020090109032
申请日：2009-11-12
Applicant: 가톨릭관동대학교산학협력단
IPC: C07D317/10 , A61K31/40 , A61K31/4196 , A61P9/12
Abstract: 본 발명은 혈압강하 효능을 갖는 파르네실아세톤 유도체 및 이를 함유한 항고혈압 제제용 약제학적 조성물에 관한 것으로서, 본 발명의 화합물은 L-형 칼슘채널을 선택적으로 억제하여 혈압상승을 효과적으로 억제할 뿐만 아니라 부작용을 최소화하여, 고혈압 치료에 매우 유용한 약제학적 조성물로 이용될 수 있다.
파르네실아세톤 유도체-
Patent Agency Ranking6.发明公开ＰＰＡＲ의 작용에 의해 조절되는 질환을 예방 또는 치료하기 위한 약학 조성물, ＰＰＡＲγ 작용제, ＰＰＡＲα 작용제, ＰＰＡＲ의 작용에 의해 조절되는 질환을 예방 또는 개선하기 위한 건강식품 및 약학 조성물의 제조 방법 有权用于PPAR，PPARγAGONIST，PPAR和ALPHA控制的疾病的预防或医疗治疗的药物组合物; 用于预防或改善由PPAR控制的疾病的健康食品，以及制备药物组合物的方法
公开(公告)号：KR1020100032670A
公开(公告)日：2010-03-26
申请号：KR1020080091651
申请日：2008-09-18
Applicant: 가톨릭관동대학교산학협력단
Abstract: PURPOSE: A pharmaceutical composition for preventing or treating diseases regulated by PPAR activity is provided to prevent and treat obesity and diabetes. CONSTITUTION: A pharmaceutical composition for preventing and treating diseases regulated by PPAR(Peroxisome Proliferator-activated Receptor) activity contains at least one ingredient selected from Ahnfeltiopsis flabelliformis extract, Sargassum yezoense extract, Corallina pilulifera extract, Dermonema pulvinatum extract, Polysiphonia morrowii extract, Grateloupia prolongata extract, Prionitis cornea extract, and Sargassum micracanthum extract as active ingredient. The extract is isolated using water, alcohol or mixture thereof. The PPAR is PPARα or PPARγ.
Abstract translation: 目的：提供一种预防或治疗由PPAR活性调节的疾病的药物组合物，用于预防和治疗肥胖症和糖尿病。 构成：用于预防和治疗由PPAR（过氧化物酶体增殖物激活受体）活性调节的疾病的药物组合物含有至少一种选自松属植物提取物，马齿苋提取物，珊瑚提取物，番茄提取物，多毛藻提取物， 提取物，朊病毒角膜提取物和马齿苋提取物作为活性成分。 使用水，醇或其混合物分离提取物。 PPAR是PPARα或PPARγ。
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7.发明公开꽈배기모자반 추출물의 구성성분 및 그 제조방법, 꽈배기모자반 추출물을 포함하는 혈관확장제 및 꽈배기모자반 추출물의 구성성분을 포함하는 혈관확장제 有权使用沙棘提取物或其有效成分的血管舒张作用来预防和调节小儿麻痹症
公开(公告)号：KR1020090049171A
公开(公告)日：2009-05-18
申请号：KR1020070115288
申请日：2007-11-13
Applicant: 가톨릭관동대학교산학협력단
Abstract: 본 발명은 물, 알코올 또는 이들의 혼합물로 추출되는 꽈배기모자반 (Sargassum siliquastrum)추출물과 그 구성성분인 (5E,10E)-6,10,14- trimethylpentadeca-5,10-diene-2,12-dione (311), (5
E ,10
Z )-6,10,14- trimethylpentadeca-5,10-diene-2,12-dione (312), (5E,10E)-14-hydroxy- 2,6,10-trimethylpentadeca-5,10-dien-4-one (3221), 그리고 (R)-3,4-dihydro-2-((S,3E,7E)-10-hydroxy-4,8,12-trimethyltrideca-3,7,11-trienyl)-2,8-dimethyl-2H-chromen-6-ol (3222)의 정제 및 분리방법, 그리고 이를 유효성분으로 함유한 식품이나 건강보조제의 용도에 관한 것으로서, 보다 상세하게는, 토끼의 기저동맥에 꽈배기모자반의 추출물을 처치하거나, 유효성분인 311, 312, 3321, 3322 화합물을 처치한 기저동맥 확장실험을 통해 기저동맥의 수축이나 막힘으로 발생하기 쉬운 뇌졸중의 예방과 치료 또는 증상 및 후유증 경감에 관한 것이다.
꽈배기모자반, 꽈배기모자반 추출물, 기저동맥, 기저동맥확장, 뇌졸중 예방 및 치료제-
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公开(公告)号：KR1020110052116A
公开(公告)日：2011-05-18
申请号：KR1020090109032
申请日：2009-11-12
Applicant: 가톨릭관동대학교산학협력단
IPC: C07D317/10 , A61K31/40 , A61K31/4196 , A61P9/12
Abstract: PURPOSE: A pharmaceutical composition containing farnesylacetone derivatives is provided to effectively suppress blood pressure and to treat hypertension with less side effect. CONSTITUTION: A farnesylacetone derivative is denoted by chemical formula 7. A pharmaceutical composition for anti-hypertension contains the farnesylacetone deravatives or pharmaceutically acceptable salt thereof as an active ingredient. A pharmaceutical composition for anti-hypertension formulation contains farnesylacetone derivative of chemical formula 311 or 312, or pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition is manufactured in the form of tablet, capsule, liquid, syrup, and injection.
Abstract translation: 目的：提供含有法呢基丙酮衍生物的药物组合物，有效抑制血压，治疗副作用少。 构成：法呢基丙酮衍生物由化学式7表示。用于抗高血压的药物组合物含有法呢基丙酮衍生物或其药学上可接受的盐作为活性成分。 用于抗高血压制剂的药物组合物含有化学式311或312的法呢基丙酮衍生物或其药学上可接受的盐作为活性成分。 药物组合物以片剂，胶囊，液体，糖浆和注射剂的形式制备。
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公开(公告)号：KR1020110052109A
公开(公告)日：2011-05-18
申请号：KR1020090109022
申请日：2009-11-12
Applicant: 가톨릭관동대학교산학협력단
IPC: C07D317/10 , A61K31/40 , A61K31/4196 , A61P9/12
Abstract: PURPOSE: A method for preparing farnesylactone derivatives and an intermediate of the derivative are provided to effectively perform organic synthesis of 6,10,14-trimethylpentadeca-5,10-diene-2,12-dione. CONSTITUTION: A method for preparing farnesylactone compound comprises: a step of reacting a compound of chemical formula 4 with ethylene glycol and p-toluene sulfonic acid to prepare a compound of chemical formula 5; a step of reacting the compound of chemical formula 5 with sodium methoxide to obtain a compound of chemical formula 6; a step of reacting the compound of chemical formula 6 with diisobutyl aluminum hydride to obtain a compound of chemical formula 7; a step of reacting the compound of chemical formula 7 with isobutyl magnesium bromide to obtain a compound of chemical formula 8; a step of reacting the compound of chemical formula 8 with pyridinium chloro chromate to obtain a compound of chemical formula 9; and a step of reacting the compound of chemical formula 9 with pyridium p-toluenesulfonate.
Abstract translation: 目的：提供制备法呢基内酯衍生物和衍生物中间体的方法，以有效地进行6,10,14-三甲基十五碳-5,10-二烯-2,12-二酮的有机合成。 构成：制备法呢基酯化合物的方法包括：使化学式4的化合物与乙二醇和对甲苯磺酸反应制备化学式5的化合物的步骤; 使化学式5的化合物与甲醇钠反应以获得化学式6的化合物的步骤; 使化学式6的化合物与二异丁基氢化铝反应得到化学式7的化合物的步骤; 使化学式7的化合物与异丁基溴化镁反应以获得化学式8的化合物的步骤; 使化学式8的化合物与氯铬酸吡啶鎓反应以获得化学式9的化合物的步骤; 和使化学式9化合物与对甲苯磺酸吡啶鎓反应的步骤。
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