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公开(公告)号：WO2010032988A2
公开(公告)日：2010-03-25
申请号：PCT/KR2009/005331
申请日：2009-09-18
Applicant: 서울대학교산학협력단 , 이윤식 , 노진미 , 곽선영
IPC: C07D309/36
CPC classification number: C07D309/36
Abstract: 본 발명은 아미노산이 결합된 코직산 금속 착물 유도체에 관한 것이다. 보다 상세하게는 본 발명은 피부 미백 효과가 있는, 아미노산이 도입된 코직산 금속 착물 유도체 및 그 제조방법에 대한 것이다.
Abstract translation: 本发明涉及与氨基酸结合的曲酸金属络合物衍生物。 更具体地，本发明涉及其中引入氨基酸的曲酸金属络合物衍生物及其制备方法，其中曲酸金属络合物衍生物具有皮肤美白效果。
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公开(公告)号：KR101224809B1
公开(公告)日：2013-01-21
申请号：KR1020120042495
申请日：2012-04-24
Applicant: 서울대학교산학협력단 , 주식회사 아이피어리스
IPC: C07C403/18 , C07K5/00 , A61K31/203 , A61Q19/08
Abstract: PURPOSE: A retinoic acid derivative is provided to have low cytotoxicity, and a collagen synthetic activity, thereby improving wrinkle-reducing effect of a cosmetic composition. CONSTITUTION: A manufacturing method of retinoic acid derivative indicated in chemical formula 1 comprises: a step of synthesizing -Gly-Arg-Glu-Pro by reacting Fmoc-amino acid onto an aminomethyl polystyrene or 2- chlorotrityl chloride polystyrene resin in which a rink amide is accepted under the presence of a coupling agent, and removing Fmoc by treating the result by 20% piperidine/NMP; a step of combining retinoic acid to the -Gly-Arg-Glu-Pro; a step of treating the result by 25% trifluoroacetic acid and dichloromethane to separate the compound indicated in chemical formula 1 from the solid resin. In chemical formula 1, R is -Gly-Arg-Glu-Pro-NH2.
Abstract translation: 目的：提供视黄酸衍生物以具有低细胞毒性和胶原合成活性，从而提高化妆品组合物的皱纹减少效果。 构成：化学式1表示的视黄酸衍生物的制造方法包括：通过使Fmoc-氨基酸与氨基甲基聚苯乙烯或2-氯三苯甲基氯化物聚苯乙烯树脂反应来合成Gly-Arg-Glu-Pro的步骤，其中， 在偶联剂存在下被接受，通过用20％哌啶/ NMP处理结果除去Fmoc; 将视黄酸与-Gly-Arg-Glu-Pro结合的步骤; 用25％三氟乙酸和二氯甲烷处理结果以将化学式1所示的化合物与固体树脂分离的步骤。 在化学式1中，R是-Gly-Arg-Glu-Pro-NH 2。
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公开(公告)号：KR1020100033889A
公开(公告)日：2010-03-31
申请号：KR1020080092964
申请日：2008-09-22
Applicant: 서울대학교산학협력단
IPC: C07D309/36
CPC classification number: C07D309/36
Abstract: PURPOSE: A kojic acid metal complex derivative which is combined with amino acid is provided to enhance whitening effect through melanogenesis suppression with high stability and improve cell permeability using copper or zinc. CONSTITUTION: A kojic acid derivative has an amino acid of chemical formula I or II. A skin whitening agent contains a kojic metal complex derivative in which amino acid of chemical formula I or II is induced. A method for manufacturing the kojic acid derivative having the amino acid of chemical formula I comprises: a step of activating 7-hydroxy group of kojic acid; a step of introducing amino acid to rink amide resin; and a step of reacting the activate kojic acid with the rink amide resin.
Abstract translation: 目的：提供与氨基酸组合的曲酸金属络合物衍生物，以通过高稳定性的黑色素生成抑制增强美白效果，并通过铜或锌提高细胞渗透性。 构成：曲酸衍生物具有化学式I或II的氨基酸。 皮肤美白剂含有其中诱导了化学式I或II的氨基酸的曲酸金属络合物衍生物。 制备具有化学式I的氨基酸的曲酸衍生物的方法包括：活化曲酸的7-羟基的步骤; 向氨基酸酰胺树脂中引入氨基酸的步骤; 以及使活化曲酸与胭脂酰胺树脂反应的步骤。
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公开(公告)号：KR101433419B1
公开(公告)日：2014-08-29
申请号：KR1020100106052
申请日：2010-10-28
Applicant: 서울대학교산학협력단 , 주식회사 아이피어리스
IPC: C07C259/06 , A61K8/42 , A61Q19/02 , A61Q17/04
Abstract: 본 발명은 하이드록시시나믹산-아미노산-하이드록시아민산 유도체에 관한 것이다. 보다 상세하게는, 본 발명은 항산화 효과 및 미백 효과를 갖는 하이드록시시나믹산-아미노산-하이드록시아민산 유도체 및 이의 피부 미백 및 노화방지용 화장품에 대한 용도에 대한 것이다.
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Patent Agency Ranking
公开(公告)号：KR1020130108828A
公开(公告)日：2013-10-07
申请号：KR1020120030596
申请日：2012-03-26
Applicant: 서울대학교산학협력단 , 주식회사 아이피어리스
Abstract: PURPOSE: A composition for a skin whitening effect is provided to show superior antioxidation and tyrosinase suppression activities and to effectively reduce melanogenesis without cytotoxicity with effective whitening activity. CONSTITUTION: A composition for a skin whitening effect contains milk protein-derived oliogopeptides or a derivative thereof. The oligopeptides are prepared by hydrolysis of milk proteins. The milk protein-derived oligopeptides are selected among YFYPEL, YFYP, FYPE, YPEL, YVEEL, YVEE, VEEL, YVEL, MHIRL, MHIR, HIRL, WYSLAMAA, WYSL, YSLA, SLAM, LAMA, and AMAA. The derivative of the oligopeptides is a compound which is prepared by conjugation of C1-C20 alkyl at amine terminal of the milk protein-derived oligopeptides through amine bond.
Abstract translation: 目的：提供一种用于皮肤美白效果的组合物，以显示出优异的抗氧化和酪氨酸酶抑制活性，并有效减少黑素生成而无有效增白活性的细胞毒性。 构成：用于皮肤美白效果的组合物含有乳蛋白衍生的奥利肽或其衍生物。 寡肽通过乳蛋白水解制备。 乳蛋白衍生的寡肽选自YFYPEL，YFYP，FYPE，YPEL，YVEEL，YVEE，VEEL，YVEL，MHIRL，MHIR，HIRL，WYSLAMAA，WYSL，YSLA，SLAM，LAMA和AMAA。 寡肽的衍生物是通过在乳蛋白衍生的寡肽的胺末端通过胺键缀合C1-C20烷基而制备的化合物。
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公开(公告)号：KR1020110012148A
公开(公告)日：2011-02-09
申请号：KR1020090069734
申请日：2009-07-30
Applicant: 서울대학교산학협력단
IPC: C07C225/16 , C07K7/06 , A61K8/64 , A61Q19/08
CPC classification number: C07K7/08 , A61K8/64 , A61K2800/522 , A61Q19/02 , A61Q19/08 , C07K5/06104 , C07K5/06165 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/101 , C07K5/1024 , C07K7/06
Abstract: PURPOSE: Hydroxycinnamoyl-peptide derivatives are provided to improve free radical removal ability by introducing a biocompartible antioxidant peptide to conventional antioxidant hydroxycinnamic acids and to increase self oxidation inhibitory ability of fatty. CONSTITUTION: A method for preparing hydroxycinnamoyl-peptide derivatives represented by chemical formula (I) comprises the steps of: synthesizing peptide(R^4) in a solid resin phase; bonding a compound of chemical formula (II) to the peptide; and separating a material in which the compound of chemical formula (II) and the peptide are bonded from the resin to obtain a compound of chemical formula (I).
Abstract translation: 目的：提供羟基肉桂酰肽衍生物，通过向常规的抗氧化羟基肉桂酸引入生物相容的抗氧化肽，提高脂肪的自氧化抑制能力，提高自由基的去除能力。 构成：由化学式（I）表示的制备羟基肉桂酰肽衍生物的方法包括以下步骤：合成固体树脂相中的肽（R ^ 4）; 将化学式（II）的化合物与肽结合; 从树脂中分离出化学式（II）的化合物与肽结合的材料，得到化学式（I）的化合物。
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公开(公告)号：KR1020130120241A
公开(公告)日：2013-11-04
申请号：KR1020120043347
申请日：2012-04-25
Applicant: 서울대학교산학협력단
CPC classification number: A61K47/6925 , A61K47/6923 , A61K2121/00
Abstract: The present invention relates to a biodegradable or biocompatible drug delivery carrier containing porous ceramic nanoparticles and a production method of the same. More specifically the present invention relates to the biodegradable or biocompatible drug delivery carrier with drugs containing porous ceramic nanoparticles and the production method of the same.
Abstract translation: 本发明涉及含有多孔陶瓷纳米粒子的生物降解性或生物相容性药物递送载体及其制备方法。 更具体地说，本发明涉及具有含有多孔陶瓷纳米粒子的药物的生物可降解或生物相容性药物递送载体及其制备方法。
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公开(公告)号：KR1020130023912A
公开(公告)日：2013-03-08
申请号：KR1020110087018
申请日：2011-08-30
Applicant: 서울대학교산학협력단 , 주식회사 네오디엠
Abstract: PURPOSE: An amino acid or peptide stabilized with nanoliposome and a functional cosmetic composition containing the same are provided to stably penetrate the skin with a peptide mixture and to maximize efficiency. CONSTITUTION: A functional cosmetic composition using an amino acid or a peptide stabilized with a nanoliposome contains an amino acid or a peptide mixture, and an emulsifying base. The emulsifying base is prepared using lecithin, ceramide, cholesterol, a derivative thereof and phytosterol, or a derivative thereof. The peptide mixture is 2-8 linear and circular peptides, a peptide derivative, and a mixture thereof.
Abstract translation: 目的：提供用纳米脂质体稳定的氨基酸或肽和含有它们的功能性化妆品组合物，以用肽混合物稳定地渗透皮肤并最大限度地提高效率。 构成：使用氨基酸或用纳米脂质体稳定的肽的功能化妆品组合物含有氨基酸或肽混合物和乳化基质。 乳化碱使用卵磷脂，神经酰胺，胆固醇，其衍生物和植物甾醇或其衍生物制备。 肽混合物是2-8个直链和环状肽，肽衍生物及其混合物。
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公开(公告)号：KR1020120044645A
公开(公告)日：2012-05-08
申请号：KR1020100106052
申请日：2010-10-28
Applicant: 서울대학교산학협력단 , 주식회사 아이피어리스
IPC: C07C259/06 , A61K8/42 , A61Q19/02 , A61Q17/04
Abstract: PURPOSE: Hydroxycinnamoic acid-amino acid-hydroxamic acid derivatives are provided to restrain enzyme activation like tyrosinase, etc, thereby having excellent antioxidant effect and whitening effect. CONSTITUTION: A hydroxycinnamoic acid-amino acid-hydroxamic acid derivative is in chemical formula 1. In chemical formula 1, R^1=R^2=OH and R^3=H, or R^1=OCH3, R^2=OH and R^3=H, or R^1=R^3=OCH3 and R^2=OH, and R^4 is asparagine, cysteine, glutamine, glycine, serine, threonine, tyrosine, lysine, aspartic acid, glutamic acid, arginine, histidine, alanine, valine, leucine, isoleucine, methionine, phenylalanine, tryptophane, or proline.
Abstract translation: 目的：提供羟基肉桂酸 - 氨基酸 - 异羟肟酸衍生物，以抑制酶活化，如酪氨酸酶等，从而具有优异的抗氧化作用和美白效果。 组成：羟基肉桂酸 - 氨基酸 - 异羟肟酸衍生物在化学式1中。在化学式1中，R 1 = R 2 = OH和R 3 = H，或R 1 = OCH 3，R 2 = OH和R ^ 3 = H，或R 1 = R 3 = OCH 3和R 2 = OH，R 4是天冬酰胺，半胱氨酸，谷氨酰胺，甘氨酸，丝氨酸，苏氨酸，酪氨酸，赖氨酸，天冬氨酸，谷氨酸 酸，精氨酸，组氨酸，丙氨酸，缬氨酸，亮氨酸，异亮氨酸，甲硫氨酸，苯丙氨酸，色氨酸或脯氨酸。
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