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1.发明公开자성체 나노입자를 함유한 코어-외각 구조의 금 나노입자의자기공명영상의 티2 조영제, 암 진단제 및 암치료제로서의 용도 无效含有磁性纳米粒子的核心金纳米粒子用于MRI T2对比剂，癌症诊断和治疗的应用
公开(公告)号：KR1020080035926A
公开(公告)日：2008-04-24
申请号：KR1020060102604
申请日：2006-10-20
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: A61K49/1887 , B82Y5/00
Abstract: A core-shell gold nanoparticle containing magnetic nanoparticles is provided to improve image clearness of MRI(magnetic resonance image) as MRI T2 contrast agent, and efficiency of cancer diagnosis, and rapidly kill the cancer cells by using laser pulse, so that diagnosis and treatment of cancer are performed simultaneously. A core-shell gold nanoparticle contains a silica core having diameter of 50-500 nm and a gold nanoshell having diameter of 50-500 nm with magnetic nanoparticles having diameter of 2-30 nm which contains polyalkylene glycol on the surface of nanoparticles and a target-directing ligand linked to the polyalkylene glycol, wherein the magnetic nanoparticle is selected from magnetite(Fe3O4), maghemite(gamma-Fe3O4), cobalt ferrite(CoFe2O4), manganese oxide(MnO), manganese ferrite(MnFe2O4), ion-platinum alloy, cobalt-platinum alloy and cobalt; the target-directing ligand is selected from anti-HER2/neu, folate, aptamer and TAT peptide.
Abstract translation: 提供含有磁性纳米颗粒的核壳金纳米颗粒，以提高MRI（MRI）造影剂的MRI（磁共振图像）的图像清晰度和癌症诊断的效率，并通过使用激光脉冲快速杀死癌细胞，从而进行诊断和治疗 的癌症同时进行。 核 - 壳金纳米颗粒包含直径为50-500nm的二氧化硅芯和直径为50-500nm的金纳米壳，其直径为2-30nm的磁性纳米颗粒，其在纳米颗粒的表面上含有聚亚烷基二醇和靶 其中磁性纳米颗粒选自磁铁矿（Fe3O4），磁赤铁矿（γ-Fe3O4），钴铁氧体（CoFe2O4），氧化锰（MnO），锰铁氧体（MnFe2O4），离子 - 铂合金 ，钴 - 铂合金和钴; 靶向配体选自抗HER2 / neu，叶酸，适体和TAT肽。
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公开(公告)号：KR1020070068871A
公开(公告)日：2007-07-02
申请号：KR1020050130946
申请日：2005-12-27
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: C01B33/18 , A61K47/02 , B01J20/103 , B01J20/28004 , B01J20/28083 , C01P2004/64 , C01P2006/16
Abstract: A preparation process of mesoporous silica nanoparticles with a diameter of about 150 nm comprising uniform-sized pores containing uniform magnetic nanoparticles, semiconductor nanoparticles, or a mixture thereof, and mesoporous silica nanoparticles having excellent performance by reducing the size and surface area of the particles and increasing the internal volume of the pores compared with mesoporous silica nanoparticles prepared by conventional processes are provided. Mesoporous silica nanoparticles containing inorganic nanoparticles comprise: a silica outer layer; inorganic nanoparticles contained in the silica outer layer; and pores with a diameter of 2 to 10 nm passing through the silica outer layer. The silica nanoparticles have a diameter of 50 to 250 nm. The pores have a diameter of 2 to 5 nm. A preparation process of mesoporous silica nanoparticles containing inorganic nanoparticles comprises the steps of: (i) dispersing hydrophobic inorganic nanoparticles dispersed into an organic solvent into an aqueous solution into which a surfactant is dissolved to prepare an aqueous dispersion of inorganic nanoparticles surrounded by the surfactant; and (ii) injecting a silica precursor into the prepared aqueous dispersion to form an outer layer made from mesoporous silica on the inorganic nanoparticles.
Abstract translation: 直径为约150nm的介孔二氧化硅纳米颗粒的制备方法，其包含均匀磁性纳米颗粒，半导体纳米颗粒或其混合物的均匀尺寸的孔，以及通过减小颗粒的尺寸和表面积而具有优异性能的介孔二氧化硅纳米颗粒，以及 提供与通过常规方法制备的介孔二氧化硅纳米颗粒相比增加孔的内部体积。 含有无机纳米颗粒的介孔二氧化硅纳米粒子包括：二氧化硅外层; 二氧化硅外层中含有的无机纳米粒子; 和通过二氧化硅外层的直径为2至10nm的孔。 二氧化硅纳米粒子的直径为50〜250nm。 孔的直径为2〜5nm。 含有无机纳米颗粒的介孔二氧化硅纳米颗粒的制备方法包括以下步骤：（i）将分散在有机溶剂中的疏水性无机纳米颗粒分散在其中溶解有表面活性剂的水溶液中以制备被表面活性剂包围的无机纳米颗粒的水分散体; 和（ii）将二氧化硅前体注入所制备的水分散体中以形成由无机纳米颗粒上的介孔二氧化硅制成的外层。
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公开(公告)号：KR1020080051285A
公开(公告)日：2008-06-11
申请号：KR1020060122077
申请日：2006-12-05
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: C01G49/04 , A61K9/5115 , A61K9/5192 , B82Y30/00 , C01B13/18 , C01F5/06 , C01F7/441 , C01G49/06 , C01P2002/72 , C01P2004/03 , C01P2004/04 , C01P2004/34 , C01P2004/62 , C01P2004/64 , C01P2004/90 , C01P2006/12 , C01P2006/17
Abstract: A method for preparing metal oxide hollow nanocapsules is provided to produce the metal oxide hollow nanocapsules having excellent dispersibility in a water system and a uniform size distribution. A method for preparing metal oxide hollow nanocapsules includes the steps of: (a) dispersing metal oxyhydroxide particles in a mixture of water and alcohol to obtain a metal oxyhydroxide dispersion; (b) adding a silica precursor to the metal oxyhydroxide dispersion to form a silica coating layer on a metal oxyhydroxide particle by a sol-gel reaction; (c) heat-treating the metal oxyhydroxide having a silica coating layer to prepare the metal oxide hollow nanocapsules having a silica coating layer; and (d) removing the silica coating layer. Further, the metal oxyhydroxide is selected from akaganeite, boehmite, heterogenite, chromia aerogel, indium oxyhydroxide, manganite, nickel oxyhydroxide or tungsten oxyhydroxide.
Abstract translation: 提供了制备金属氧化物空心纳米胶囊的方法，以制备在水系中具有优异分散性和均匀尺寸分布的金属氧化物中空纳米胶囊。 制备金属氧化物空心纳米胶囊的方法包括以下步骤：（a）将金属羟基氧化物颗粒分散在水和醇的混合物中，得到氢氧化金属氢氧化物分散体; （b）将二氧化硅前体加入到羟基氧化金属分散体中，通过溶胶 - 凝胶反应在金属羟基氧化物颗粒上形成二氧化硅涂层; （c）对具有二氧化硅涂层的金属氢氧化物进行热处理以制备具有二氧化硅涂层的金属氧化物空心纳米胶囊; 和（d）除去二氧化硅涂层。 此外，金属氢氧化物选自菱铁矿，勃姆石，异质岩，氧化铬气凝胶，羟基氧化铟，亚锰酸盐，羟基氧化镍或羟基氧化钨。
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公开(公告)号：KR100846839B1
公开(公告)日：2008-07-16
申请号：KR1020060122077
申请日：2006-12-05
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: C01G49/04 , A61K9/5115 , A61K9/5192 , B82Y30/00 , C01B13/18 , C01F5/06 , C01F7/441 , C01G49/06 , C01P2002/72 , C01P2004/03 , C01P2004/04 , C01P2004/34 , C01P2004/62 , C01P2004/64 , C01P2004/90 , C01P2006/12 , C01P2006/17
Abstract: 본 발명은 수계에 잘 분산되는 산화금속 중공 나노캡슐의 제조방법 및 이로부터 제조된 산화철 중공 나노캡슐에 관한 발명이다.
본 발명에 따른 산화금속 중공 나노캡슐의 제조방법은 금속 옥시수산화물 입자를 수계에 분산시킨 후 상기 금속 옥시수산화물 입자 상에 실리카 코팅층을 형성한 후 이를 열처리하여 실리카 코팅층 내부에 중공형의 산화금속층이 형성한 후 실리카를 제거하는 과정을 통해 이루어지는 것을 특징으로 한다. 본 발명의 제조방법에 의해 제조된 산화금속 중공 나노캡슐은 수계 분산성이 우수하고 균일한 입도분포를 가질 뿐만아니라 내부 중공에 생리 활성 물질을 담지할 수 있는 효과가 있다.
또한, 본 발명에 따른 산화철 나노캡슐은 100 m
2 /g 이상의 큰 표면적과 좁은 분포의 중형 기공(meso pore)을 지니고 있어 생리 활성 물질의 담지가 가능하며, 약물전달 같은 생명의학적 응용, 가스센서(gas sensor), 리튬 이온전지(Li ion battery) 등 광범위한 산업적 응용의 가능성을 기대할 수 있다.
금속 옥시수산화물, 중공 나노캡슐, 산화철
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