公开(公告)号：KR100847395B1

公开(公告)日：2008-07-18

申请号：KR1020070017011

申请日：2007-02-20

Applicant: 재단법인서울대학교산학협력재단

Inventor： 추원식 ,  김성근 ,  안성훈 ,  하원식 ,  지상철

IPC: A61K9/00

CPC classification number: A61K47/50 ,  A61K9/00 ,  A61K2121/00

Abstract: A preparation method of drug delivery system is provided to serve a constant pattern to the system, insert one or various kinds of drugs into the system, and control the drug release from the system by regulating the size and shape of drug delivery system, and the size and shape of pores. A preparation method of drug delivery system(20a) comprises the steps of: mixing drugs and polymer to prepare a drug-polymer composite(10,12); establishing the shape of drug delivery system containing the drug-polymer composite; filing the drug-polymer composite into a disperser(110); and pouring the drug-polymer composite from the dispenser to an X-Y table(120) along a certain pathway, wherein the X-Y table moves on a horizontal plane, and the dispenser moves perpendicularly to the horizontal plane; and the shape of drug delivery system has scaffold structure. Further, the drug delivery system has a scaffold structure.

Abstract translation: 提供了一种药物输送系统的制备方法，用于系统的恒定模式，将一种或多种药物插入系统，并通过调节药物输送系统的大小和形状来控制药物从体系释放， 毛孔的大小和形状。 药物递送系统（20a）的制备方法包括以下步骤：混合药物和聚合物以制备药物 - 聚合物复合物（10,12）; 建立含有药物 - 聚合物复合材料的药物输送系统的形状; 将药物 - 聚合物复合材料填充到分散器（110）中; 并且将所述药物 - 聚合物复合物从所述分配器沿着特定路径倾倒到X-Y工作台（120），其中所述X-Y工作台在水平面上移动，并且所述分配器垂直于所述水平面移动; 药物输送系统的形状具有脚手架结构。 此外，药物递送系统具有支架结构。

公开(公告)号：KR1020080035926A

公开(公告)日：2008-04-24

申请号：KR1020060102604

申请日：2006-10-20

Applicant: 재단법인서울대학교산학협력재단

Inventor： 현택환 ,  김재윤 ,  조명행 ,  김성근 ,  이정희

IPC: A61K49/06 ,  A61K49/12

CPC classification number: A61K49/1887 ,  B82Y5/00

Abstract: A core-shell gold nanoparticle containing magnetic nanoparticles is provided to improve image clearness of MRI(magnetic resonance image) as MRI T2 contrast agent, and efficiency of cancer diagnosis, and rapidly kill the cancer cells by using laser pulse, so that diagnosis and treatment of cancer are performed simultaneously. A core-shell gold nanoparticle contains a silica core having diameter of 50-500 nm and a gold nanoshell having diameter of 50-500 nm with magnetic nanoparticles having diameter of 2-30 nm which contains polyalkylene glycol on the surface of nanoparticles and a target-directing ligand linked to the polyalkylene glycol, wherein the magnetic nanoparticle is selected from magnetite(Fe3O4), maghemite(gamma-Fe3O4), cobalt ferrite(CoFe2O4), manganese oxide(MnO), manganese ferrite(MnFe2O4), ion-platinum alloy, cobalt-platinum alloy and cobalt; the target-directing ligand is selected from anti-HER2/neu, folate, aptamer and TAT peptide.

Abstract translation: 提供含有磁性纳米颗粒的核壳金纳米颗粒，以提高MRI（MRI）造影剂的MRI（磁共振图像）的图像清晰度和癌症诊断的效率，并通过使用激光脉冲快速杀死癌细胞，从而进行诊断和治疗 的癌症同时进行。 核 - 壳金纳米颗粒包含直径为50-500nm的二氧化硅芯和直径为50-500nm的金纳米壳，其直径为2-30nm的磁性纳米颗粒，其在纳米颗粒的表面上含有聚亚烷基二醇和靶 其中磁性纳米颗粒选自磁铁矿（Fe3O4），磁赤铁矿（γ-Fe3O4），钴铁氧体（CoFe2O4），氧化锰（MnO），锰铁氧体（MnFe2O4），离子 - 铂合金 ，钴 - 铂合金和钴; 靶向配体选自抗HER2 / neu，叶酸，适体和TAT肽。