公开(公告)号：KR100827784B1

公开(公告)日：2008-05-07

申请号：KR1020070018328

申请日：2007-02-23

Applicant: 재단법인서울대학교산학협력재단

Inventor： 신문삼 ,  김화용

IPC: C08F299/04 ,  C08F220/06 ,  C08G61/12 ,  A61K9/00

CPC classification number: C08F220/14 ,  A61K31/78 ,  C08F2/44 ,  C08F290/141 ,  C08G63/08 ,  C08J3/095 ,  C08J3/12

Abstract: A novel poly(caprolactone-methyl methacrylate) copolymer, a method for preparing the copolymer, and a method for preparing an agent for treating the skin disease such as acne, atopy, athlete's foot, etc. by using the copolymer are provided to control the drug delivery velocity and to improve skin disease treatment efficiency by increasing effective crosssectional area. A poly(caprolactone-methyl methacrylate) copolymer comprises the repeating unit represented by the formula and has a number average molecular weight of 5,000-50,000, wherein m and n are 10-1,000, respectively. The copolymer is prepared by injecting caprolactone and methyl methacrylate into a reactor in a ratio of 1:1 TO 1:1.5 by weight; injecting a 2,2-azobisisobutyronitrile initiator in a ratio of 0.1-1.0 by weight to the total amount of the monomers; and polymerizing them at a temperature of 283.15-353.15 K and at a pressure of 50-300 atm for 1-168 hours.

Abstract translation: 提供新型聚（己内酯 - 甲基丙烯酸甲酯）共聚物，共聚物的制备方法，以及通过使用该共聚物制备治疗皮肤疾病如痤疮，特应性，运动脚等的药剂的方法，以控制 药物输送速度，并通过增加有效的横截面积来改善皮肤病治疗效率。 聚（己内酯 - 甲基丙烯酸甲酯）共聚物包含由式表示的重复单元，其数均分子量为5,000-50,000，其中m和n分别为10-1,000。 共聚物的制备方法是将己内酯和甲基丙烯酸甲酯以1：1至1：1.5的比例注入反应器中; 以相对于单体总量为0.1-1.0重量比注入2,2-偶氮二异丁腈引发剂; 并在283.15-353.15K的温度和50-300atm的压力下聚合它们1-168小时。

公开(公告)号：KR100818685B1

公开(公告)日：2008-04-01

申请号：KR1020060122043

申请日：2006-12-05

Applicant: 재단법인서울대학교산학협력재단

Inventor： 신문삼 ,  김화용

IPC: C07C65/10

CPC classification number: Y02P20/544 ,  C07C51/43 ,  A61K9/14 ,  A61K31/60 ,  C07C65/10

Abstract: A method for preparing salicylic acid microparticles is provided to obtain fine salicylic acid particles having an increased effective surface area and showing increasing skin absorptivity. A method for preparing salicylic acid microparticles utilizes a supercritical fluid process in which a mixed solution containing salicylic acid dissolved in an organic solvent is sprayed to and contacted with a supercritical fluid to produce salicylic acid particles, and then a supercritical fluid is introduced thereto to remove the organic solvent. In the method, the organic solvent is used in an amount corresponding to a weight fraction of salicylic acid of 0.0001-0.50.

Abstract translation: 提供了制备水杨酸微粒的方法，以获得具有增加的有效表面积并显示出增加的皮肤吸收性的精细水杨酸颗粒。 制备水杨酸微粒的方法利用超临界流体法，其中将含有溶于有机溶剂中的水杨酸的混合溶液喷射并与超临界流体接触以产生水杨酸颗粒，然后将超临界流体引入其中以除去 有机溶剂。 在该方法中，有机溶剂的用量相当于水杨酸的重量百分比为0.0001-0.50。

公开(公告)号：KR1020080060074A

公开(公告)日：2008-07-01

申请号：KR1020060134163

申请日：2006-12-26

Applicant: 재단법인서울대학교산학협력재단

Inventor： 신문삼 ,  김화용

IPC: A61K31/4164 ,  C07D233/54 ,  A61P17/00

CPC classification number: Y02P20/544 ,  A61K31/4164 ,  C07D233/54

Abstract: A process for producing nanoparticles of imidazole is provided to increase the effective sectional area of imidazole particles and skin absorption rate of imidazole through the supercritical fluid process using supercritical carbon dioxide, so that the therapeutic effects of imidazole on dandruff are improved. A process for producing nanoparticles of imidazole comprises the steps of: (1) dissolving 0.0001-0.50 wt.% of imidazole in ethanol as an organic solvent to prepare a mixture solution; (2) contacting the mixture solution with supercritical carbon dioxide as supercritical fluid through spraying to form imidazole nanoparticles; (3) removing the organic solvent from the imidazole nanoparticles by using the additional supercritical fluid; and (4) recovering the formed imidazole nanoparticles.

Abstract translation: 提供一种制备咪唑纳米颗粒的方法，通过超临界二氧化碳超临界流体加工咪唑颗粒的有效截面面积和咪唑皮肤吸收率，从而提高咪唑对头皮屑的治疗效果。 制备咪唑纳米颗粒的方法包括以下步骤：（1）将0.0001-0.50重量％的咪唑溶于乙醇作为有机溶剂以制备混合溶液; （2）通过喷雾将混合溶液与超临界二氧化碳作为超临界流体接触，形成咪唑纳米颗粒; （3）通过使用附加的超临界流体从咪唑纳米颗粒中除去有机溶剂; 和（4）回收形成的咪唑纳米颗粒。

公开(公告)号：KR1020080060059A

公开(公告)日：2008-07-01

申请号：KR1020060134136

申请日：2006-12-26

Applicant: 재단법인서울대학교산학협력재단

Inventor： 신문삼 ,  김화용

IPC: A61K9/16 ,  A61K31/16 ,  B82Y5/00

CPC classification number: A61K9/14 ,  A61K31/16 ,  B82Y5/00 ,  Y10S514/859

Abstract: A process for producing nanoparticles of panthenol is provided to increase skin absorption rate of panthenol by increasing effective cross section through supercritical fluid process, so that the nanoparticles of panthenol are useful for treating acnes without side effects. A process for producing nanoparticles of panthenol comprises the steps of: solubilizing 0.0001-0.50 wt.% of panthenol in organic solvent such as ethanol to prepare the panthenol solution; spraying the panthenol solution to supercritical fluid to form panthenol nanoparticles; and removing the organic solvent from the panthenol nanoparticles by introducing the additional supercritical fluid to the panthenol nanoparticles; and collecting the formed panthenol nanoparticles.

Abstract translation: 提供了一种生产泛醇纳米颗粒的方法，以通过超临界流体工艺增加有效截面来提高泛醇的皮肤吸收率，使泛醇的纳米颗粒可用于治疗痤疮而无副作用。 一种生产泛醇纳米颗粒的方法，包括以下步骤：将0.0001-0.50重量％的泛醇溶于有机溶剂如乙醇中以制备泛醇溶液; 将泛醇溶液喷洒到超临界流体中以形成泛醇纳米颗粒; 并通过将额外的超临界流体引入到泛醇纳米颗粒中从泛醇纳米颗粒中除去有机溶剂; 并收集形成的泛醇纳米颗粒。

公开(公告)号：KR1020080044527A

公开(公告)日：2008-05-21

申请号：KR1020060113487

申请日：2006-11-16

Applicant: 재단법인서울대학교산학협력재단

Inventor： 신문삼 ,  김화용

IPC: A61K9/16 ,  A61K9/51 ,  B82Y5/00

CPC classification number: A61K31/4412 ,  A61J3/00 ,  B82Y5/00 ,  Y10S514/859

Abstract: A method for preparing nano-particles of piroctone olamine is provided to micronize the piroctone olamine through a supercritical fluid process using a supercritical CO2, thereby obtaining the piroctone olamine with increased skin absorption rate due to increased effective cross section. A method for preparing nano-particles of piroctone olamine comprises the steps of: (a) contacting a mixture solvent obtained by dissolving piroctone olamine into an organic solvent with a supercritical fluid by spraying the mixture solvent to generate piroctone olamine particles; and (b) removing the organic solvent from the particles by introducing a supercritical fluid thereinto, wherein 0.0001-0.50 wt.%, preferably 0.001-0.20 wt.% of the organic solvent is used regarding the weight of the piroctone olamine.

Abstract translation: 提供了一种制备吡罗酮醇胺的纳米颗粒的方法，以通过使用超临界CO 2的超临界流体方法使焦pi酮醇胺微粉化，从而由于增加的有效截面获得具有增加的皮肤吸收速率的吡罗昔康醇。 一种制备吡罗酮醇胺的纳米颗粒的方法包括以下步骤：（a）通过喷雾混合溶剂以将焦虑酮醇胺溶解于有机溶剂中而获得的混合溶剂与超临界流体接触以产生吡罗昔酮醇胺颗粒; 并且（b）通过向其中引入超临界流体从颗粒中除去有机溶剂，其中使用0.0001-0.50重量％，优选0.001-0.20重量％的有机溶剂关于吡罗酮醇的重量。

公开(公告)号：KR100811447B1

公开(公告)日：2008-03-11

申请号：KR1020060122039

申请日：2006-12-05

Applicant: 재단법인서울대학교산학협력재단

Inventor： 신문삼 ,  김화용

IPC: B82B3/00 ,  D01D5/00

CPC classification number: A61K31/164 ,  A61K8/68 ,  B82B3/0038 ,  B82Y40/00

Abstract: A method for preparing a ceramide nano-particle is provided to obtain the ceramide with increased skin absorption rate due to increase of an effective cross-sectional area by micronizing a particle size of the ceramide through a supercritical fluid process using a supercritical CO2. A method for preparing a ceramide nano-particle comprises the steps of: (a) mixing 0.0001-0.50 wt.% of ceramide with ethanol to prepare a mixture solution; (b) spraying the mixture solution with the speed of 0.5-1.5ml/minute into a reactor where CO2 is contained at a temperature of 313-333K under a pressure of 130-170 bar with injecting CO2 into the reactor with the speed of 2.5-3.5kg/hour to generate ceramide particles; and (c) introducing CO2 into the reactor to remove the ethanol therefrom to prepare ceramide particles having a size of 50-150 nanometers.

Abstract translation: 提供了一种制备神经酰胺纳米颗粒的方法，通过使用超临界CO 2通过超临界流体法微粉化神经酰胺的颗粒尺寸，由于增加了有效的横截面积，从而获得具有增加的皮肤吸收速率的神经酰胺。 制备神经酰胺纳米颗粒的方法包括以下步骤：（a）将0.0001-0.50重量％的神经酰胺与乙醇混合以制备混合溶液; （b）将混合物溶液以0.5-1.5ml /分钟的速度喷入反应器中，其中含有CO 2的温度为313-333K，压力为130-170巴，将CO 2以2.5的速度注入反应器 -3.5kg /小时产生神经酰胺颗粒; 和（c）将CO 2引入反应器以从其中除去乙醇以制备尺寸为50-150纳米的神经酰胺颗粒。

公开(公告)号：KR100802278B1

公开(公告)日：2008-02-11

申请号：KR1020060134131

申请日：2006-12-26

Applicant: 재단법인서울대학교산학협력재단

Inventor： 신문삼 ,  이용진 ,  김화용

IPC: A61K9/16 ,  B82Y5/00

CPC classification number: A61K9/1635 ,  A61K9/1694 ,  A61K9/5138 ,  A61K9/5192

Abstract: A method for preparing a nanostructure containing vitamin K is provided to solve a problem of remaining organic solvent by using a supercritical fluid extraction system and increase the skin permeation rate of the vitamin K by nano-sizing the vitamin K and control the medicinal effect delivering speed of a drug by containing a biodegradable polymer together with the drug. A method for preparing a nanostructure comprises the steps of: (a) dissolving vitamin K and a biodegradable polymer such as poly-isopropyl-butylmethacrylate-acrylic acid copolymer in an organic solvent such as ethanol to prepare a mixture solution; (b) spraying the mixture solution into a reactor containing a supercritical fluid such as CO2 to generate spherical vitamin K structure particles; (c) further introducing the supercritical fluid same as the step(b) into the reactor containing the spherical vitamin K structure particles to remove the organic solvent therefrom; and (d) recovering the organic solvent removed vitamin K structure particles.

Abstract translation: 提供一种制备含有维生素K的纳米结构的方法，通过使用超临界流体萃取系统解决残留有机溶剂的问题，并通过纳米级维生素K调节维生素K的皮肤渗透速率并控制药效递送速度 的药物通过与药物一起含有可生物降解的聚合物。 制备纳米结构的方法包括以下步骤：（a）将维生素K和可生物降解的聚合物如聚异丙基 - 甲基丙烯酸甲酯 - 丙烯酸共聚物溶解在有机溶剂如乙醇中以制备混合溶液; （b）将混合溶液喷入包含超临界流体如CO 2的反应器中以产生球形维生素K结构颗粒; （c）将与步骤（b）相同的超临界流体进一步加入到含有球形维生素K结构颗粒的反应器中以从其中除去有机溶剂; 和（d）回收除去的有机溶剂的维生素K结构颗粒。

公开(公告)号：KR1020080060092A

公开(公告)日：2008-07-01

申请号：KR1020060134190

申请日：2006-12-26

Applicant: 재단법인서울대학교산학협력재단

Inventor： 신문삼 ,  김화용

IPC: A61K9/16 ,  A61K31/375 ,  B82Y5/00

CPC classification number: A61K9/16 ,  A61K31/375 ,  B82Y5/00

Abstract: A process for preparing ascorbic acid nanoparticles is provided to increase skin absorption rate of ascorbic acid by increasing the sectional area of ascorbic acid particles and improve skin striae-treating effects of ascorbic acid by using rapid expansion of supercritical system. A process for preparing ascorbic acid nanoparticles comprises the steps of: dissolving 0.0001-0.50 wt.% based on the weight of ethanol of ascorbic acid in ethanol; spraying the ascorbic acid dissolved solvent to the supercritical carbon dioxide through a nozzle to prepare ascorbic acid nanoparticles; flowing the supercritical carbon dioxide to the ascorbic acid nanoparticles in several times to extract and remove ethanol; and recovering the ascorbic acid nanoparticles.

Abstract translation: 提供制备抗坏血酸纳米颗粒的方法，通过增加抗坏血酸颗粒的截面面积，通过使用超临界系统的快速膨胀，改善抗坏血酸的皮肤条纹治疗效果，增加抗坏血酸的皮肤吸收率。 制备抗坏血酸纳米颗粒的方法包括以下步骤：将基于抗坏血酸乙醇重量的0.0001-0.50重量％溶于乙醇中; 通过喷嘴将抗坏血酸溶解溶剂喷涂到超临界二氧化碳中，制备抗坏血酸纳米粒子; 将超临界二氧化碳数次流过抗坏血酸纳米颗粒提取和除去乙醇; 并回收抗坏血酸纳米颗粒。

公开(公告)号：KR1020080060082A

公开(公告)日：2008-07-01

申请号：KR1020060134179

申请日：2006-12-26

Applicant: 재단법인서울대학교산학협력재단

Inventor： 신문삼 ,  김화용

IPC: A61K9/16 ,  A61K31/566 ,  B82Y5/00

CPC classification number: A61K9/14 ,  A61K31/566 ,  B82Y5/00 ,  Y10S514/859

Abstract: A process for preparing phytoestrogen nanoparticles is provided to improve acne-treating effects of phytoestrogen by increasing skin absorption rate and sectional area of phytoestrogen particles through the supercritical fluid process. The phytoestrogen nanoparticles are prepared by dissolving phytoestrogen in organic solvent selected from methanol and ethanol to prepare a mixture solution, contacting the mixture solution with the supercritical fluid selected from supercritical carbon dioxide, supercritical nitrogen monoxide, supercritical methane trichloride, supercritical propane, supercritical ethylene and supercritical xenon through spraying to form phytoestrogen nanoparticles, washing the phytoestrogen nanoparticles by introducing the additional supercritical fluid into the phytoestrogen nanoparticles, and recovering the phytoestrogen nanoparticles having the particle size of 100-300 nm.

Abstract translation: 提供了一种制备植物雌激素纳米颗粒的方法，通过增加植物雌激素颗粒通过超临界流体过程的皮肤吸收率和截面积来改善植物雌激素的痤疮治疗效果。 通过将植物雌激素溶解在选自甲醇和乙醇的有机溶剂中制备植物雌激素纳米颗粒，以制备混合溶液，使混合溶液与超临界二氧化碳，超临界一氧化氮，超临界三氯化甲烷，超临界甲烷，超临界乙烯和 超临界氙通过喷雾形成植物雌激素纳米颗粒，通过将额外的超临界流体引入植物雌激素纳米颗粒来洗涤植物雌激素纳米颗粒，并回收粒径为100-300nm的植物雌激素纳米颗粒。

公开(公告)号：KR1020080044541A

公开(公告)日：2008-05-21

申请号：KR1020060113510

申请日：2006-11-16

Applicant: 재단법인서울대학교산학협력재단

Inventor： 신문삼 ,  김화용

IPC: A61K9/16 ,  A61K9/51 ,  A61K9/14 ,  B82Y5/00

CPC classification number: A61K47/6925 ,  B01J2/02 ,  B01J3/008

Abstract: A method for preparing nano-triclocarban is provided to obtain ultra-fine particles of triclocarban with predicted skin efficacy due to increased effective cross-section, thereby the nano-triclocarban being applied to quasi-drugs. A method for preparing nano-triclocarban comprises the steps of: (a) dissolving triclocarban into an organic solvent; (b) spraying the mixture solution obtained from the step(a) into a supercritical fluid to generate triclocarban particles; (c) introducing a supercritical fluid into the particles to remove the organic solvent therefrom; and (d) recovering the generated particles, wherein the organic solvent used regarding the organic solvent is 0.0001-0.50 wt.%, preferably 0.001-0.20 wt.%.

Abstract translation: 提供了一种制备纳米三氯班的方法，以获得具有预期的皮肤功效的三氯卡班超细颗粒，由于有效的横截面增加，纳米三氯班素被应用于准药物。 一种制备纳米三氯丹的方法包括以下步骤：（a）将三氯巴酚溶于有机溶剂中; （b）将从步骤（a）获得的混合溶液喷射到超临界流体中以产生三氯苯胺颗粒; （c）将超临界流体引入颗粒中以从其中除去有机溶剂; 和（d）回收生成的颗粒，其中关于有机溶剂使用的有机溶剂为0.0001-0.50重量％，优选0.001-0.20重量％。