公开(公告)号：KR100818685B1

公开(公告)日：2008-04-01

申请号：KR1020060122043

申请日：2006-12-05

Applicant: 재단법인서울대학교산학협력재단

Inventor： 신문삼 ,  김화용

IPC: C07C65/10

CPC classification number: Y02P20/544 ,  C07C51/43 ,  A61K9/14 ,  A61K31/60 ,  C07C65/10

Abstract: A method for preparing salicylic acid microparticles is provided to obtain fine salicylic acid particles having an increased effective surface area and showing increasing skin absorptivity. A method for preparing salicylic acid microparticles utilizes a supercritical fluid process in which a mixed solution containing salicylic acid dissolved in an organic solvent is sprayed to and contacted with a supercritical fluid to produce salicylic acid particles, and then a supercritical fluid is introduced thereto to remove the organic solvent. In the method, the organic solvent is used in an amount corresponding to a weight fraction of salicylic acid of 0.0001-0.50.

Abstract translation: 提供了制备水杨酸微粒的方法，以获得具有增加的有效表面积并显示出增加的皮肤吸收性的精细水杨酸颗粒。 制备水杨酸微粒的方法利用超临界流体法，其中将含有溶于有机溶剂中的水杨酸的混合溶液喷射并与超临界流体接触以产生水杨酸颗粒，然后将超临界流体引入其中以除去 有机溶剂。 在该方法中，有机溶剂的用量相当于水杨酸的重量百分比为0.0001-0.50。

公开(公告)号：KR1020100006008A

公开(公告)日：2010-01-18

申请号：KR1020080066150

申请日：2008-07-08

Applicant: 재단법인서울대학교산학협력재단

Inventor： 이윤우 ,  신영호 ,  김화용 ,  강병희

IPC: C02F1/72 ,  C02F11/06

CPC classification number: C02F1/72 ,  C02F11/06 ,  Y02W10/15 ,  Y02W10/20

Abstract: PURPOSE: A method for processing and mixing organic wastewater and inorganic wastewater and a processing device therefor are provided to collect organic materials and to decompose organic materials at the same time by applying supercritical water oxidation technology. CONSTITUTION: A method for processing and mixing organic wastewater and inorganic wastewater includes an inorganic wastewater supplying pump(12), an organic wastewater supplying pump(14), an oxidizer supply pump(16), an inorganic wastewater heater(22), an organic wastewater heater(24), a mixer(32), an oxidation reactor(34), a first heat-exchanger(36), a second heat-exchanger(38), and a particle separator(40). The inorganic wastewater supply pump is connected to the inorganic wastewater heater through a first supply line. The organic wastewater supply pump is connected to the first heat exchanger through a second supply line. The oxidizer supply pump is connected to the mixer through a third supply line. The mixer is installed at the top of the inside the oxidation reactor. The oxidation reactor is equipped between the mixer and the first heat exchanger.

Abstract translation: 目的：提出一种处理和混合有机废水和无机废水的方法及其处理装置，通过超临界水氧化技术同时收集有机材料和分解有机物质。 构成：有机废水和无机废水的处理和混合方法包括无机废水供应泵（12），有机废水供应泵（14），氧化剂供应泵（16），无机废水加热器（22），有机废水 废水加热器（24），混合器（32），氧化反应器（34），第一热交换器（36），第二热交换器（38）和颗粒分离器（40）。 无机废水供应泵通过第一条供应管线连接到无机废水加热器。 有机废水供应泵通过第二供应管线连接到第一热交换器。 氧化剂供应泵通过第三条供应管线连接到混合器。 混合器安装在氧化反应器内部的顶部。 氧化反应器配备在混合器和第一热交换器之间。

公开(公告)号：KR1020090024396A

公开(公告)日：2009-03-09

申请号：KR1020070089393

申请日：2007-09-04

Applicant: 재단법인서울대학교산학협력재단

Inventor： 김화용 ,  오경실 ,  배원

IPC: C08F2/14 ,  C08F2/22 ,  C08F6/10 ,  C08J3/12

CPC classification number: C08F2/14 ,  C08F4/04 ,  C08F6/10 ,  C08J3/12

Abstract: A method for synthesizing a polymer microparticle using DME(dimethyl ether) is provided to polymerize monomers to obtain a polymer microparticle in no need of a process of separating a solvent. A method for synthesizing a polymer microparticle using DME(dimethyl ether) comprises the following steps of: mixing a monomer, initiator, dispersing agent, and DME(demethyl ether) as a solvent in a reactor; polymerizing a polymer with above described materials at a temperature of 50-80 °C with a pressure of 20 bar or greater; and decompressing and removing the DME to obtain a pure polymer microparticle.

Abstract translation: 提供使用DME（二甲醚）合成聚合物微粒的方法，以聚合单体以获得无需分离溶剂的方法的聚合物微粒。 使用DME（二甲醚）合成聚合物微粒的方法包括以下步骤：将单体，引发剂，分散剂和DME（去甲基醚）作为溶剂混合在反应器中; 在50-80℃的温度下以20巴或更大的压力聚合具有上述材料的聚合物; 并减压除去DME以获得纯聚合物微粒。

公开(公告)号：KR100867082B1

公开(公告)日：2008-11-04

申请号：KR1020080052955

申请日：2008-06-05

Applicant: 재단법인서울대학교산학협력재단

Inventor： 김화용 ,  이용진

IPC: C08F220/00 ,  C08G63/91 ,  A61K9/00 ,  B82Y5/00

CPC classification number: Y02P20/544 ,  C08F220/18 ,  A61K9/1635 ,  A61K9/51 ,  C08F220/56 ,  C08G63/91 ,  C08J3/12

Abstract: A therapeutic agent for pimple and atopic dermatitis containing a nanostructure using the supercritical fluid can perform the drug action in the specific pH by containing a nanostructure in which diameter is 50~100nm. A therapeutic agent for pimple and atopic dermatitis containing a nanostructure using the supercritical fluid is prepared by manufacturing a poly-carprolactone-isopropyl acrylamide-acrylic acid terpolymer which is a biodegradable polymer by using the supercritical fluid; and mixing it with triclosan by again using the supercritical fluid.

Abstract translation: 使用超临界流体含有纳米结构的疙瘩和特应性皮炎治疗剂可以通过含有直径为50〜100nm的纳米结构体在特定pH下进行药物作用。 通过使用超临界流体制造作为可生物降解的聚合物的聚己内酯 - 异丙基丙烯酰胺 - 丙烯酸三元共聚物，制备含有使用超临界流体的纳米结构的疙瘩和特应性皮炎的治疗剂。 并再次使用超临界流体与三氯生混合。

公开(公告)号：KR100840132B1

公开(公告)日：2008-06-23

申请号：KR1020070037619

申请日：2007-04-17

Applicant: 재단법인서울대학교산학협력재단

Inventor： 주준호 ,  신내철 ,  김화용 ,  이윤우

IPC: C07D501/59 ,  B01D11/00

Abstract: A method for drying cefpodoxime proxetil is provided to obtain the cefpodoxime proxetil with almost no remaining solvent with reduced cost and drying time by performing a drying process using a saturated liquid CO2, which is relatively cheap, harmless to human body and non-reactive with a product. A method for drying cefpodoxime proxetil comprises a step of removing at least one remaining organic solvent selected from the group consisting of diisopropylether, ethyl acetate and dichloromethane by circulating saturated liquid carbon dioxide using a reboiler and a condenser without using a power unit such as a pump during a process of preparing the cefpodoxime proxetil.

Abstract translation: 提供了一种干燥头孢泊肟原料的方法，通过使用相对便宜的对人体无害的并且与人体无反应的饱和液体CO 2进行干燥处理，几乎没有残留的溶剂，几乎没有残留的溶剂，从而获得头孢泊肟几乎没有残留的溶剂 产品。 用于干燥头孢泊肟原料的方法包括通过使用再沸器和冷凝器循环饱和液体二氧化碳除去至少一种选自二异丙醚，乙酸乙酯和二氯甲烷的剩余有机溶剂的步骤，而不使用动力单元如泵 在制备头孢泊肟原料的过程中。

公开(公告)号：KR100827784B1

公开(公告)日：2008-05-07

申请号：KR1020070018328

申请日：2007-02-23

Applicant: 재단법인서울대학교산학협력재단

Inventor： 신문삼 ,  김화용

IPC: C08F299/04 ,  C08F220/06 ,  C08G61/12 ,  A61K9/00

CPC classification number: C08F220/14 ,  A61K31/78 ,  C08F2/44 ,  C08F290/141 ,  C08G63/08 ,  C08J3/095 ,  C08J3/12

Abstract: A novel poly(caprolactone-methyl methacrylate) copolymer, a method for preparing the copolymer, and a method for preparing an agent for treating the skin disease such as acne, atopy, athlete's foot, etc. by using the copolymer are provided to control the drug delivery velocity and to improve skin disease treatment efficiency by increasing effective crosssectional area. A poly(caprolactone-methyl methacrylate) copolymer comprises the repeating unit represented by the formula and has a number average molecular weight of 5,000-50,000, wherein m and n are 10-1,000, respectively. The copolymer is prepared by injecting caprolactone and methyl methacrylate into a reactor in a ratio of 1:1 TO 1:1.5 by weight; injecting a 2,2-azobisisobutyronitrile initiator in a ratio of 0.1-1.0 by weight to the total amount of the monomers; and polymerizing them at a temperature of 283.15-353.15 K and at a pressure of 50-300 atm for 1-168 hours.

Abstract translation: 提供新型聚（己内酯 - 甲基丙烯酸甲酯）共聚物，共聚物的制备方法，以及通过使用该共聚物制备治疗皮肤疾病如痤疮，特应性，运动脚等的药剂的方法，以控制 药物输送速度，并通过增加有效的横截面积来改善皮肤病治疗效率。 聚（己内酯 - 甲基丙烯酸甲酯）共聚物包含由式表示的重复单元，其数均分子量为5,000-50,000，其中m和n分别为10-1,000。 共聚物的制备方法是将己内酯和甲基丙烯酸甲酯以1：1至1：1.5的比例注入反应器中; 以相对于单体总量为0.1-1.0重量比注入2,2-偶氮二异丁腈引发剂; 并在283.15-353.15K的温度和50-300atm的压力下聚合它们1-168小时。

公开(公告)号：KR100951955B1

公开(公告)日：2010-04-09

申请号：KR1020080066150

申请日：2008-07-08

Applicant: 재단법인서울대학교산학협력재단

Inventor： 이윤우 ,  신영호 ,  김화용 ,  강병희

IPC: C02F1/72 ,  C02F11/06

Abstract: 초임계수 산화반응을 이용하여 독립적으로 발생하는 유기폐수 및 무기폐수를 혼합하여 처리하는 방법이 개시된다. 유기폐수 및 무기폐수의 혼합 처리 방법에 있어서, 유기폐수 및 무기폐수는 각각 또는 혼합되어 고압펌프로 연속적으로 주입된 후, 예열기로 가열되고, 반응기에서 처리되고 열교환을 거쳐 배출된다. 무기폐수는 반응기에서 무기입자를 형성하여 유기폐수의 유기물 분해를 촉진시킴으로써, 유기폐수의 유기물 분해율을 향상시키고, 무기입자를 회수할 수 있다.

公开(公告)号：KR1020100035252A

公开(公告)日：2010-04-05

申请号：KR1020080094515

申请日：2008-09-26

Applicant: 재단법인서울대학교산학협력재단

Inventor： 이윤우 ,  강병희 ,  신영호 ,  김화용

IPC: C08F6/06 ,  C08F6/10 ,  C08F220/00 ,  C08F220/06

CPC classification number: Y02P20/544 ,  C08F220/06 ,  C08F6/10 ,  C08J3/24

Abstract: PURPOSE: A method for preparing superabsorbent polymer is provided to effectively reduce toxic acrylic acid remaining within the super absorbent polymer and dimmer thereof within a fast time in a low temperature condition. CONSTITUTION: A method for preparing superabsorbent polymer comprises the steps of: (a) injecting pressurized fluid or supercritical fluid or their mixture into the superabsorbent polymer formed by polymerizing acrylic acid dissolved in a solvent, acrylate monomer, and crosslinking monomer; (b) extracting acrylic acid remaining within the superabsorbent polymer using the pressurized fluid, supercritical fluid or their mixture; (c) pressurizing and separating the pressurized fluid dissolved in a solvent, supercritical fluid or their mixture; and (d) recovering the superabsorbent polymer from which acrylic acid is removed.

Abstract translation: 目的：提供一种制备超吸收性聚合物的方法，以在低温条件下快速时间内有效地减少残留在超吸收聚合物及其调色剂中的有毒丙烯酸。 构成：制备超吸收性聚合物的方法包括以下步骤：（a）将加压流体或超临界流体或其混合物注入通过聚合溶解在溶剂中的丙烯酸，丙烯酸酯单体和交联单体形成的超吸收聚合物中; （b）使用加压流体，超临界流体或其混合物提取剩余在超吸收性聚合物内的丙烯酸; （c）加压和分离溶解在溶剂，超临界流体或其混合物中的加压流体; 和（d）回收除去丙烯酸的超吸收性聚合物。

公开(公告)号：KR1020090070846A

公开(公告)日：2009-07-01

申请号：KR1020070138987

申请日：2007-12-27

Applicant: 재단법인서울대학교산학협력재단

Inventor： 김화용 ,  이용진 ,  장성현

IPC: B82B3/00 ,  B82B1/00 ,  B82Y40/00

CPC classification number: B82B3/0038 ,  A61K9/5123 ,  A61K9/513 ,  B82Y5/00

Abstract: A method for manufacturing supercritical nanostructure containing ceramide is provided to make big particle size of ceramide smaller in order to increase a skin absorption rate and to adjust a drug delivery rate by using a supercritical fluid of molecular association theory. A method for manufacturing supercritical nanostructure containing ceramide comprises the following steps of: spraying a mixed solution prepared by dissolving ceramide and biodegradable polymer in an organic solvent to a supercritical fluid in order to generate a ceramide and biodegradable polymer structure particle; and removing the organic solvent used by introducing the supercritical fluid to the particles. The particle with a size of 100nm or less can be obtained by setting specific processing conditions including temperature variation, pressure variation and flux variation of supercritical carbon dioxide.

Abstract translation: 提供一种制备含有神经酰胺的超临界纳米结构体的方法，以便通过使用分子缔合理论的超临界流体来增加皮肤吸收率和调节药物输送速率，从而使得较大的神经酰胺粒度较小。 一种制备含有神经酰胺的超临界纳米结构体的方法，包括以下步骤：将通过将有机溶剂中的神经酰胺和可生物降解的聚合物溶解在超临界流体中而制备的混合溶液，以产生神经酰胺和可生物降解的聚合物结构颗粒; 并通过将超临界流体引入颗粒中去除所用的有机溶剂。 通过设定包括温度变化，压力变化和超临界二氧化碳的通量变化的具体加工条件，可以获得尺寸为100nm以下的粒子。

公开(公告)号：KR100874125B1

公开(公告)日：2008-12-15

申请号：KR1020070068895

申请日：2007-07-09

Applicant: 재단법인서울대학교산학협력재단

Inventor： 이윤우 ,  김화용 ,  주준호 ,  신내철

IPC: C07D501/34 ,  C07D501/36 ,  C07D501/12

CPC classification number: Y02P20/544 ,  C07D501/12 ,  C07D501/34

Abstract: A method for preparing cefpodoxime proxetil is provided to remove a remaining solvent nearly or completely by carrying out the drying process by using supercritical and subcritical carbon dioxide. A method for preparing cefpodoxime proxetil comprises the step of drying it by using the supercritical and subcritical carbon dioxide at a temperature of 0-70 deg.C and at a pressure of 35-600 atm. to remove the remaining organic solvent.

Abstract translation: 提供制备头孢泊肟酯的方法，通过使用超临界和亚临界二氧化碳进行干燥过程，几乎或完全地除去残留的溶剂。 制备头孢泊肟原料的方法包括使用超临界和亚临界二氧化碳在0-70℃和35-600atm压力下干燥方法。 以除去剩余的有机溶剂。