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公开(公告)号：KR1020090070846A
公开(公告)日：2009-07-01
申请号：KR1020070138987
申请日：2007-12-27
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: B82B3/0038 , A61K9/5123 , A61K9/513 , B82Y5/00
Abstract: A method for manufacturing supercritical nanostructure containing ceramide is provided to make big particle size of ceramide smaller in order to increase a skin absorption rate and to adjust a drug delivery rate by using a supercritical fluid of molecular association theory. A method for manufacturing supercritical nanostructure containing ceramide comprises the following steps of: spraying a mixed solution prepared by dissolving ceramide and biodegradable polymer in an organic solvent to a supercritical fluid in order to generate a ceramide and biodegradable polymer structure particle; and removing the organic solvent used by introducing the supercritical fluid to the particles. The particle with a size of 100nm or less can be obtained by setting specific processing conditions including temperature variation, pressure variation and flux variation of supercritical carbon dioxide.
Abstract translation: 提供一种制备含有神经酰胺的超临界纳米结构体的方法，以便通过使用分子缔合理论的超临界流体来增加皮肤吸收率和调节药物输送速率，从而使得较大的神经酰胺粒度较小。 一种制备含有神经酰胺的超临界纳米结构体的方法，包括以下步骤：将通过将有机溶剂中的神经酰胺和可生物降解的聚合物溶解在超临界流体中而制备的混合溶液，以产生神经酰胺和可生物降解的聚合物结构颗粒; 并通过将超临界流体引入颗粒中去除所用的有机溶剂。 通过设定包括温度变化，压力变化和超临界二氧化碳的通量变化的具体加工条件，可以获得尺寸为100nm以下的粒子。
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公开(公告)号：KR1020090070755A
公开(公告)日：2009-07-01
申请号：KR1020070138879
申请日：2007-12-27
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: B82B3/0038 , A61K9/5123 , A61K9/513 , B82Y5/00
Abstract: Provided is a method for manufacturing supercritical nanostructure containing triclosan using a density fluctuation theory, which controls a drug delivery rate. A method for manufacturing supercritical nanostructure containing triclosan using a density fluctuation theory comprises the following steps of: spraying a mixed solution prepared by dissolving triclosan and biodegradable polymer in an organic solvent to a supercritical fluid in order to generate a triclosan and biodegradable polymer structure particle; and removing the organic solvent used by introducing the supercritical fluid to the particles. The biodegradable polymer of poly-isopropyl-butyl methacrylate-acrylic acid copolymer is used to control a drug delivery rate. The supercritical nanostructure has a particle size of 100nm or less.
Abstract translation: 提供一种使用密度波动理论制造含有三氯生的超临界纳米结构的方法，其控制药物递送率。 一种使用密度波动理论制造含有三氯生的超临界纳米结构的方法，包括以下步骤：将三氯生和可生物降解的聚合物溶于有机溶剂中制备的混合溶液喷涂到超临界流体中，以产生三氯生和可生物降解的聚合物结构颗粒; 并通过将超临界流体引入颗粒中去除所用的有机溶剂。 聚异丙基 - 甲基丙烯酸丁酯 - 丙烯酸共聚物的生物可降解聚合物用于控制药物递送率。 超临界纳米结构的粒径为100nm以下。
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公开(公告)号：KR100802278B1
公开(公告)日：2008-02-11
申请号：KR1020060134131
申请日：2006-12-26
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: A61K9/1635 , A61K9/1694 , A61K9/5138 , A61K9/5192
Abstract: A method for preparing a nanostructure containing vitamin K is provided to solve a problem of remaining organic solvent by using a supercritical fluid extraction system and increase the skin permeation rate of the vitamin K by nano-sizing the vitamin K and control the medicinal effect delivering speed of a drug by containing a biodegradable polymer together with the drug. A method for preparing a nanostructure comprises the steps of: (a) dissolving vitamin K and a biodegradable polymer such as poly-isopropyl-butylmethacrylate-acrylic acid copolymer in an organic solvent such as ethanol to prepare a mixture solution; (b) spraying the mixture solution into a reactor containing a supercritical fluid such as CO2 to generate spherical vitamin K structure particles; (c) further introducing the supercritical fluid same as the step(b) into the reactor containing the spherical vitamin K structure particles to remove the organic solvent therefrom; and (d) recovering the organic solvent removed vitamin K structure particles.
Abstract translation: 提供一种制备含有维生素K的纳米结构的方法，通过使用超临界流体萃取系统解决残留有机溶剂的问题，并通过纳米级维生素K调节维生素K的皮肤渗透速率并控制药效递送速度 的药物通过与药物一起含有可生物降解的聚合物。 制备纳米结构的方法包括以下步骤：（a）将维生素K和可生物降解的聚合物如聚异丙基 - 甲基丙烯酸甲酯 - 丙烯酸共聚物溶解在有机溶剂如乙醇中以制备混合溶液; （b）将混合溶液喷入包含超临界流体如CO 2的反应器中以产生球形维生素K结构颗粒; （c）将与步骤（b）相同的超临界流体进一步加入到含有球形维生素K结构颗粒的反应器中以从其中除去有机溶剂; 和（d）回收除去的有机溶剂的维生素K结构颗粒。
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公开(公告)号：KR100867082B1
公开(公告)日：2008-11-04
申请号：KR1020080052955
申请日：2008-06-05
Applicant: 재단법인서울대학교산학협력재단
IPC: C08F220/00 , C08G63/91 , A61K9/00 , B82Y5/00
CPC classification number: Y02P20/544 , C08F220/18 , A61K9/1635 , A61K9/51 , C08F220/56 , C08G63/91 , C08J3/12
Abstract: A therapeutic agent for pimple and atopic dermatitis containing a nanostructure using the supercritical fluid can perform the drug action in the specific pH by containing a nanostructure in which diameter is 50~100nm. A therapeutic agent for pimple and atopic dermatitis containing a nanostructure using the supercritical fluid is prepared by manufacturing a poly-carprolactone-isopropyl acrylamide-acrylic acid terpolymer which is a biodegradable polymer by using the supercritical fluid; and mixing it with triclosan by again using the supercritical fluid.
Abstract translation: 使用超临界流体含有纳米结构的疙瘩和特应性皮炎治疗剂可以通过含有直径为50〜100nm的纳米结构体在特定pH下进行药物作用。 通过使用超临界流体制造作为可生物降解的聚合物的聚己内酯 - 异丙基丙烯酰胺 - 丙烯酸三元共聚物，制备含有使用超临界流体的纳米结构的疙瘩和特应性皮炎的治疗剂。 并再次使用超临界流体与三氯生混合。
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