만난이 코팅된 초상자성 산화철 나노입자, 이의 제조방법및 이를 포함하는 간질환 진단용 조영제
    1.
    发明公开
    만난이 코팅된 초상자성 산화철 나노입자, 이의 제조방법및 이를 포함하는 간질환 진단용 조영제 有权
    超级纳米氧化锰纳米粒子,其制备方法和对照药物用于诊断肝病

    公开(公告)号:KR1020090090104A

    公开(公告)日:2009-08-25

    申请号:KR1020080015374

    申请日:2008-02-20

    CPC classification number: A61K49/1863 B82Y5/00 G01N2800/085 H01F1/344

    Abstract: A mannan-coated superparamagnetic iron oxide nanoparticle is provided, which enables specific flow of liver to kupffer cell and ensure stability of ferrofluid. A contrast media for diagnosing hepatism comprises a mannan coated superparamagnetic iron oxide nanoparticle. A method for manufacturing the nanoparticle comprises: a step of adding basic solution in iron chloride aqueous solution and dipping iron oxide nanoparticle; a step of oxidizing the iron oxide nanoparticle and producing storage solution; and a step of mixing mannan solution in the storage solution, stirring and coating.

    Abstract translation: 提供了一种甘露聚糖涂层的超顺磁性氧化铁纳米粒子,其能够使特定的肝脏流向枯否细胞并确保铁磁流体的稳定性。 用于诊断肝脏病的造影剂包括甘露聚糖包被的超顺磁性氧化铁纳米颗粒。 制造纳米颗粒的方法包括:将碱性溶液加入到氯化铁水溶液和浸渍氧化铁纳米颗粒中的步骤; 氧化氧化铁纳米粒子的氧化步骤,制备储存溶液; 以及将甘露聚糖溶液在储存溶液中混合,搅拌和涂布的步骤。

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