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公开(公告)号：KR101521578B1
公开(公告)日：2015-05-20
申请号：KR1020130109701
申请日：2013-09-12
Applicant: 전남대학교산학협력단 , 여수수산영어조합법인
Abstract: 본발명은즉석진주담치자숙냉동품및 이의제조방법에관한것으로, 상세하게는진주담치를자숙하는과정에서정미성분, 영양성분및 항산화능등의기능특성을가지는자숙액즙의유실을막기위해전처리후 탈각하지않고미리진공포장을한 다음포장한채로자숙및 동결하는단계와, 자숙냉동품을해동한후 즉석에서탕 또는찜으로간편하게조리해먹을수 있도록하기위한페이스트상또는분말상양념의제조단계를포함하는즉석진주담치자숙냉동품및 이의제조방법에관한것이다.
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2.发明授权
公开(公告)号：KR101167053B1
公开(公告)日：2012-07-27
申请号：KR1020090096314
申请日：2009-10-09
Applicant: 포항공과대학교 산학협력단 , 전남대학교산학협력단
Abstract: 본 발명은 세포내 유전자 전달용 복합체에 관한 것으로서, 1,000 내지 10,000 Da의 분자량을 갖는 양이온성 고분자 및 마그네틱 나노입자를 포함하는 것을 특징으로 하는 본 발명에 따른 세포내 유전자 전달용 복합체는, 안전하고 효율적인 유전자의 전달이 가능하므로 다양한 유전자를 이용한 질병 치료에 이용될 수 있다.
생명공학, 유전자 전달, 양이온성 고분자, 마그네틱 나노입자-
3.发明授权
公开(公告)号：KR100949465B1
公开(公告)日：2010-03-29
申请号：KR1020080015374
申请日：2008-02-20
Applicant: 전남대학교산학협력단
Abstract: 본 발명은 만난(mannan)이 코팅된 초상자성 산화철 나노입자, 이의 제조방법 및 이를 포함하는 간질환 진단용 조영제에 관한 것으로, 본 발명의 만난이 코팅된 초상자성 산화철 나노입자는 초상자성 산화철 용액(ferrofluid)의 안정성을 확보하고 간의 쿱퍼 세포(Kupffer cell)에 선택적으로 전달됨으로써 정확하게 간질환을 진단하는 안정한 조영제로서 유용하게 사용될 수 있다.
조영제, 초상자성, 산화철 나노입자, 만난, 간질환-
公开(公告)号：KR101789563B1
公开(公告)日：2017-11-20
申请号：KR1020160025534
申请日：2016-03-03
Applicant: 전남대학교산학협력단
Inventor： 박인규
IPC: A61K49/18 , A61K49/00 , A61K31/704
Abstract: 본발명은양친매성히알루론산으로형성되고소수성인도시아닌그린이봉입되어생체내안정성이우수하면서인도시아닌농도조절이용이한나노마이셀에관한것으로, 나노마이셀을이용하여근적외선및 광음향이중영상을통해암 조직의영상화가가능하다.
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公开(公告)号：KR1020140039998A
公开(公告)日：2014-04-02
申请号：KR1020130109701
申请日：2013-09-12
Applicant: 전남대학교산학협력단 , 여수수산영어조합법인
CPC classification number: A23L17/40 , A22C29/043 , A23L5/13 , A23L23/10 , A23V2002/00 , A23V2300/20
Abstract: The present invention relates to a precooked and frozen instant blue mussel product and a method for producing the same. More specifically, the method comprising the steps of: precooking and freezing vacuum-packed blue mussels without removing shells after pretreatment so as to prevent the loss of a liquid extract which has functions as a taste compound, a nutrient, and an antioxidant material when the blue mussels are precooked ; and producing a paste phase or powder phase seasoning so that the precooked and frozen instant blue mussel product can be easily and instantly cooked after being thawed in order to be eaten as a broth food or a casserole food. [Reference numerals] (AA) Raw product; (BB) Wash; (CC) Select; (DD) Class A product; (EE) Vacuum packing; (FF) Precook; (GG) Wash and freeze; (HH) Add in and mix with the raw product (paste seasoning); (II) Freeze (-18°C or less); (JJ) Seasoning; (KK) Re-packing (blue mussels + a seasoning); (LL) Individually packing (paste or powder seasoning); (MM) Product (precooked and frozen instant blue mussel product including seasoning)
Abstract translation: 本发明涉及预煮和冷冻速溶蓝贻贝产品及其制备方法。 更具体地说，该方法包括以下步骤：在真空包装的蓝贻贝上预煮和冷冻，而不去除预处理后的壳，以防止当作为味觉化合物，营养物和抗氧化剂材料起作用的液体提取物的损失时 蓝贻贝被煮熟; 并且生产糊状相或粉末相调料，使得预煮和冷冻的速溶蓝色贻贝产品在解冻后可以容易地立即煮熟，以便作为肉汤食品或砂锅食物食用。 （附图标记）（AA）原料; （BB）洗涤; （CC）选择; （DD）A类产品; （EE）真空包装; （FF）预制; （GG）洗涤和冷冻; （HH）加入和混合原料（酱料调味料）; （II）冷冻（-18℃以下） （JJ）调味料; （KK）重新包装（蓝贻贝+调味料）; （LL）单独包装（糊或粉末调味料）; （MM）产品（预煮和冷冻速溶蓝贻贝产品，包括调味料）
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Patent Agency Ranking
公开(公告)号：KR1020120106645A
公开(公告)日：2012-09-26
申请号：KR1020120027104
申请日：2012-03-16
Applicant: 전남대학교산학협력단
IPC: C12N15/87 , C12N15/113 , A61F2/82 , A61L27/54
CPC classification number: C12N15/87 , A61F2/82 , A61L27/54 , C12N15/113
Abstract: PURPOSE: A gene delivery system for transferring a target gene to cells is provided to enable stable delivery of the gene delivery system to an organism and to effectively suppress the expression of a specific disease gene. CONSTITUTION: A gene delivery system for transferring a target gene to cells is complexed by ionic interaction through mixing the target gene with polyethylene imine of Branched polyethylenimine cross-linked via disulfide bonds(ssPEI). The target gene is siRNA(small interfering RNA), an antisense molecule, an antagonist, ribozyme, an inhibitor, a peptide, or a small molecule. The target gene is siRNA which is specific to Akt gene. The target gene is fixed on a support. The support is a stent coated with hyaluronic acid or collagen on the surface.
Abstract translation: 目的：提供用于将靶基因转移至细胞的基因递送系统，以使基因递送系统能稳定递送至生物体并有效抑制特定疾病基因的表达。 构成：通过将靶基因与通过二硫键（ssPEI）交联的支链聚乙烯亚胺的聚乙烯亚胺混合，通过离子相互作用将用于将靶基因转移至细胞的基因递送系统复合。 靶基因是siRNA（小干扰RNA），反义分子，拮抗剂，核酶，抑制剂，肽或小分子。 靶基因是对Akt基因特异的siRNA。 靶基因固定在支持体上。 支架是表面涂有透明质酸或胶原的支架。
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7.发明公开
公开(公告)号：KR1020110039046A
公开(公告)日：2011-04-15
申请号：KR1020090096314
申请日：2009-10-09
Applicant: 포항공과대학교 산학협력단 , 전남대학교산학협력단
Abstract: PURPOSE: An intracellular gene delivery intracellular gene delivery containing cationic polymers and magnetic nanoaprticels is provided to treat various diseases using a gene. CONSTITUTION: An intracellular gene delivery composite contains cationic polymers of 1000-10,000 Da of molecular weight and magnetic nanoparticles. The cationic polymers are polyethylene imine(PEI), poly-L-lysine(PLL), or chitosan. The magnetic nanoparticles are thermally cross-linked superparamagnetic nanoparticles(TCL-SPION). The intracellular gene delivery composite is prepared by cross-linking of the cationic polymers and magnetic nanoparticles under the presence of -ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride(EDC) and N-hydroxysuccineimide(NHS).
Abstract translation: 目的：提供含有阳离子聚合物和磁性纳米胶原的细胞内基因递送细胞内基因递送，以使用基因治疗各种疾病。 构成：细胞内基因递送复合物含有1000-10,000Da分子量的阳离子聚合物和磁性纳米粒子。 阳离子聚合物是聚乙烯亚胺（PEI），聚-L-赖氨酸（PLL）或壳聚糖。 磁性纳米粒子是热交联超顺磁性纳米粒子（TCL-SPION）。 通过在乙基-3-（3-二甲基氨基丙基）碳二亚胺盐酸盐（EDC）和N-羟基琥珀酰亚胺（NHS）的存在下交联阳离子聚合物和磁性纳米颗粒来制备细胞内基因递送复合物。
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公开(公告)号：KR1020090090104A
公开(公告)日：2009-08-25
申请号：KR1020080015374
申请日：2008-02-20
Applicant: 전남대학교산학협력단
CPC classification number: A61K49/1863 , B82Y5/00 , G01N2800/085 , H01F1/344
Abstract: A mannan-coated superparamagnetic iron oxide nanoparticle is provided, which enables specific flow of liver to kupffer cell and ensure stability of ferrofluid. A contrast media for diagnosing hepatism comprises a mannan coated superparamagnetic iron oxide nanoparticle. A method for manufacturing the nanoparticle comprises: a step of adding basic solution in iron chloride aqueous solution and dipping iron oxide nanoparticle; a step of oxidizing the iron oxide nanoparticle and producing storage solution; and a step of mixing mannan solution in the storage solution, stirring and coating.
Abstract translation: 提供了一种甘露聚糖涂层的超顺磁性氧化铁纳米粒子，其能够使特定的肝脏流向枯否细胞并确保铁磁流体的稳定性。 用于诊断肝脏病的造影剂包括甘露聚糖包被的超顺磁性氧化铁纳米颗粒。 制造纳米颗粒的方法包括：将碱性溶液加入到氯化铁水溶液和浸渍氧化铁纳米颗粒中的步骤; 氧化氧化铁纳米粒子的氧化步骤，制备储存溶液; 以及将甘露聚糖溶液在储存溶液中混合，搅拌和涂布的步骤。
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公开(公告)号：KR1020170103149A
公开(公告)日：2017-09-13
申请号：KR1020160025534
申请日：2016-03-03
Applicant: 전남대학교산학협력단
Inventor： 박인규
IPC: A61K49/18 , A61K49/00 , A61K31/704
Abstract: 본발명은양친매성히알루론산으로형성되고소수성인도시아닌그린이봉입되어생체내안정성이우수하면서인도시아닌농도조절이용이한나노마이셀에관한것으로, 나노마이셀을이용하여근적외선및 광음향이중영상을통해암 조직의영상화가가능하다.
Abstract translation: 通过近红外光声和重影的本发明通过使用形成为酸两亲性透明质酸的纳米胶束和封装体内稳定性yiwoosu所示的绿色非疏水性而示出的纳米胶束浓度使用不调整 癌症组织成像是可能的。
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10.发明公开패혈증 비브리오균의 플라젤린과 알레르겐을 접합시켜 제조한 접합체 및 이를 유효성분으로 포함하는 점막 투여용 알레르겐-특이 면역치료제 有权通过将VIBRIO VULNIFICUS FLAGELLIN和ALLERGEN凝胶制成的过敏复合物，以及含有活性成分的粘膜特异性免疫抑制剂
公开(公告)号：KR1020140040503A
公开(公告)日：2014-04-03
申请号：KR1020120107258
申请日：2012-09-26
Applicant: 전남대학교산학협력단
CPC classification number: A61K38/164 , A61K39/35 , C07K14/28 , Y10S514/826 , Y10S514/857 , Y10S514/885
Abstract: The present invention relates to a conjugate prepared by conjugating mucosal vaccine adjuvants and allergen, and an allergen-specific immunotherapeutic agent; more specifically, to a conjugate prepared by using flagellin of vibrio vulnificus, which is a toll-like receptor-5 (TLR-5) drug and a vaccine adjuvant, and a hydrophilic multiple-bonded linker having a thiol group (-SH) of a dust mite extract; and a mucosal allergen-specific immunotherapeutic agent containing the same. [Reference numerals] (AA) Penh value (% relative to PBS); (BB) FlaB/HDM (10 μg) mixture; (CC) FlaB/HDM (3.5 μg) mixture; (DD) FlaB-HDM (3.5 μg) bonded body; (EE) Methacholine (mg/mL)
Abstract translation: 本发明涉及通过使粘膜疫苗佐剂和变应原和变应原特异性免疫治疗剂结合而制备的缀合物; 更具体地，涉及通过使用作为toll样受体-5（TLR-5）药物和疫苗佐剂的创伤弧菌鞭毛蛋白和具有硫醇基（-SH）的亲水性多键合连接子制备的缀合物 尘螨提取物; 和含有它们的粘膜变应原特异性免疫治疗剂。 （AA）Penh值（相对于PBS的％）; （BB）FlaB / HDM（10μg）混合物; （CC）FlaB / HDM（3.5μg）混合物; （DD）FlaB-HDM（3.5μg）粘结体; （EE）甲酰胆碱（mg / mL）
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