公开(公告)号：KR1020110091276A

公开(公告)日：2011-08-11

申请号：KR1020100011034

申请日：2010-02-05

Applicant: 전남대학교산학협력단

Inventor： 김성진 ,  박종성 ,  정용연

IPC: G01N33/483 ,  A61B10/00 ,  A61B5/04

Abstract: PURPOSE: A method for evaluating skin irritation is provided to express skin sensitivity and irritation and to replace a conventional skin stimulation test. CONSTITUTION: A method for evaluating/predicting skin irritation comprises: a step of treating a test material to organ-derived nerve cells; a step of measuring cell membrane ion potential of the nerve cells; and a step of confirming stimulation. The nerve cells are afferent sensory nerve cells or neuron. A kit for evaluating the skin irritation comprises the nerve cells and micro current measuring device.

Abstract translation: 目的：提供一种评估皮肤刺激的方法，以表达皮肤敏感性和刺激性，并替代常规的皮肤刺激试验。 构成：评估/预测皮肤刺激的方法包括：将试验材料处理到器官衍生的神经细胞的步骤; 测量神经细胞的细胞膜离子电位的步骤; 以及确认刺激的步骤。 神经细胞是传入感觉神经细胞或神经元。 用于评估皮肤刺激的试剂盒包括神经细胞和微电流测量装置。

公开(公告)号：KR100949465B1

公开(公告)日：2010-03-29

申请号：KR1020080015374

申请日：2008-02-20

Applicant: 전남대학교산학협력단

Inventor： 유미경 ,  박인규 ,  정환정 ,  정용연 ,  권진숙 ,  조종수

IPC: A61K49/06 ,  A61K49/00 ,  A61B5/055 ,  B82Y5/00

Abstract: 본 발명은 만난(mannan)이 코팅된 초상자성 산화철 나노입자, 이의 제조방법 및 이를 포함하는 간질환 진단용 조영제에 관한 것으로, 본 발명의 만난이 코팅된 초상자성 산화철 나노입자는 초상자성 산화철 용액(ferrofluid)의 안정성을 확보하고 간의 쿱퍼 세포(Kupffer cell)에 선택적으로 전달됨으로써 정확하게 간질환을 진단하는 안정한 조영제로서 유용하게 사용될 수 있다.
조영제, 초상자성, 산화철 나노입자, 만난, 간질환

公开(公告)号：KR101134088B1

公开(公告)日：2012-04-13

申请号：KR1020100011034

申请日：2010-02-05

Applicant: 전남대학교산학협력단

Inventor： 김성진 ,  박종성 ,  정용연

IPC: G01N33/483 ,  A61B10/00 ,  A61B5/04

Abstract: PURPOSE: A method for evaluating skin irritation is provided to express skin sensitivity and irritation and to replace a conventional skin stimulation test. CONSTITUTION: A method for evaluating/predicting skin irritation comprises: a step of treating a test material to organ-derived nerve cells; a step of measuring cell membrane ion potential of the nerve cells; and a step of confirming stimulation. The nerve cells are afferent sensory nerve cells or neuron. A kit for evaluating the skin irritation comprises the nerve cells and micro current measuring device.

公开(公告)号：KR1020090090104A

公开(公告)日：2009-08-25

申请号：KR1020080015374

申请日：2008-02-20

Applicant: 전남대학교산학협력단

Inventor： 유미경 ,  박인규 ,  정환정 ,  정용연 ,  권진숙 ,  조종수

IPC: A61K49/06 ,  A61K49/00 ,  A61B5/055 ,  B82Y5/00

CPC classification number: A61K49/1863 ,  B82Y5/00 ,  G01N2800/085 ,  H01F1/344

Abstract: A mannan-coated superparamagnetic iron oxide nanoparticle is provided, which enables specific flow of liver to kupffer cell and ensure stability of ferrofluid. A contrast media for diagnosing hepatism comprises a mannan coated superparamagnetic iron oxide nanoparticle. A method for manufacturing the nanoparticle comprises: a step of adding basic solution in iron chloride aqueous solution and dipping iron oxide nanoparticle; a step of oxidizing the iron oxide nanoparticle and producing storage solution; and a step of mixing mannan solution in the storage solution, stirring and coating.

Abstract translation: 提供了一种甘露聚糖涂层的超顺磁性氧化铁纳米粒子，其能够使特定的肝脏流向枯否细胞并确保铁磁流体的稳定性。 用于诊断肝脏病的造影剂包括甘露聚糖包被的超顺磁性氧化铁纳米颗粒。 制造纳米颗粒的方法包括：将碱性溶液加入到氯化铁水溶液和浸渍氧化铁纳米颗粒中的步骤; 氧化氧化铁纳米粒子的氧化步骤，制备储存溶液; 以及将甘露聚糖溶液在储存溶液中混合，搅拌和涂布的步骤。