公开(公告)号：KR101105598B1

公开(公告)日：2012-01-18

申请号：KR1020100008326

申请日：2010-01-29

Applicant: 전남대학교산학협력단 ,  (주) 켐포트

Inventor： 이기영 ,  김진 ,  정효연 ,  이용욱

IPC: A61K9/127 ,  A61P17/00

Abstract: 본 발명은 티올 키토산이 코팅된 에이코사펜타에노산 함유 리포좀 및 이의 제조방법에 관한 것으로, 상기 본 발명에 따른 티올 키토산이 코팅된 에이코사펜타에노산 함유 리포좀은 기존의 에이코사펜타에노산을 약물전달체로의 적용에 대한 어려움을 근본적으로 개선한 것이며, 우수한 아토피 피부 개선 효과 및 면역증진 효과가 있어 아토피 치료를 위한 기능성 의약품의 발전에 크게 기여할 것이다.

公开(公告)号：KR1020110088702A

公开(公告)日：2011-08-04

申请号：KR1020100008326

申请日：2010-01-29

Applicant: 전남대학교산학협력단 ,  (주) 켐포트

Inventor： 이기영 ,  김진 ,  정효연 ,  이용욱

IPC: A61K9/127 ,  A61P17/00

CPC classification number: A61K9/1271 ,  A61K9/1277 ,  A61K31/202 ,  A61K47/36 ,  Y10S514/857

Abstract: PURPOSE: An EPA-containing liposome which is coated with thiol chitosan and a method for preparing the same are provided to maximize stability, efficiency, and absorption rate. CONSTITUTION: A method for preparing EPA-containing liposome coated with thiol chitosan comprises: a step of adding a volatile organic solvent to a mixture to prepare a phospholipid solution; a step of evaporating and concentrating the phosphlipid solution to prepare a thin film; a step of adding thiol chitosan solution to the thin film; and a step of hydrating thin film to prepare liposome.

Abstract translation: 目的：提供涂有巯基壳聚糖的含EPA脂质体及其制备方法，以使稳定性，效率和吸收速度最大化。 构成：包含硫醇壳聚糖的含EPA脂质体的制备方法包括：向混合物中加入挥发性有机溶剂以制备磷脂溶液的步骤; 蒸发并浓缩磷脂溶液以制备薄膜的步​​骤; 向薄膜中添加硫醇壳聚糖溶液的步骤; 以及水合薄膜以制备脂质体的步骤。

公开(公告)号：KR1020100111423A

公开(公告)日：2010-10-15

申请号：KR1020090029851

申请日：2009-04-07

Applicant: 전남대학교산학협력단 ,  (주) 켐포트

Inventor： 이기영 ,  정경환 ,  정효연

IPC: A61K6/08

Abstract: PURPOSE: A method for manufacturing an UV protecting agent of nano capsule containing eicosapentaenoic acid(EPA) and titanium dioxide sol is provided to ensure skin dispersibility and to completely block UV. CONSTITUTION: A method for manufacturing an UV protecting agent comprises: a step of completely dissolving titanium isopropoxide and anhydrous ethanol at room temperature; a step of dropping the mixture to distilled water to obtain titanium dioxide sol; a step of dissolving chitosan into an acetic acid solution and dispersing the titanium dioxide sol and eicosapentaenoic acid to ethanol; a step of dropping into chitosan solution and stirring to obtain nanoparticles; a step of washing and drying nanoparticles; a step of separating solution and nanoparticles; and a step of storing in a freeze-drier and diluting in a small amount of water.

Abstract translation: 目的：提供含有二十碳五烯酸（EPA）和二氧化钛溶胶的纳米胶囊的紫外线防护剂的制造方法，以确保皮肤分散性和完全阻止紫外线。 构成：紫外线防护剂的制造方法包括：在室温下完全溶解异丙醇钛和无水乙醇的工序; 将混合物滴加到蒸馏水中以获得二氧化钛溶胶的步骤; 将壳聚糖溶解在乙酸溶液中并将二氧化钛溶胶和二十碳五烯酸分散到乙醇中的步骤; 滴入壳聚糖溶液并搅拌以获得纳米颗粒的步骤; 洗涤和干燥纳米颗粒的步骤; 分离溶液和纳米颗粒的步骤; 以及在冷冻干燥机中储存并稀释少量水的步骤。