公开(公告)号：KR101424032B1

公开(公告)日：2014-08-01

申请号：KR1020130040162

申请日：2013-04-12

Applicant: 조선대학교산학협력단

Inventor： 정현숙 ,  우희권 ,  박재영 ,  이범기 ,  김성심 ,  김웅 ,  최학준

IPC: A23L1/30 ,  A61K31/192 ,  A61P9/12

CPC classification number: A23L33/105 ,  A23V2002/00 ,  A23V2200/3262 ,  A61K31/192

Abstract: According to the present invention, fractions derived from pine leaves with an inhibitory activity on an angiotensin converting enzyme are selected, and dehydroabietic acid and communic acid are identified by identifying structures among the selected materials with optimum activity. Provided are a health promotion food composition comprising dehydroabietic acid or communic acid as active ingredients for preventing or curing hypertension, a pharmaceutical composition for preventing or curing hypertension, an angiotensin converting enzyme inhibitor, and a pharmaceutical composition for preventing or curing vascular diseases. According to the present invention, dehydroabietic acid or communic acid derived from pine leaves has angiotensin converting enzyme inhibitory activity, and can be provided as a useful composition for consumer`s health. Since a method for extracting and segmenting is provided specifically in the present invention, the materials with excellent activity which is abundantly contained in pine leaves can be used as an economical raw material with a high function.

Abstract translation: 根据本发明，选择从对血管紧张素转换酶具有抑制活性的松叶衍生的馏分，通过鉴定所选材料中具有最佳活性的结构来鉴定脱氢松香酸和通酸。 提供了包含脱氢枞酸或通讯酸作为预防或治疗高血压的有效成分的健康促进食品组合物，用于预防或治疗高血压的药物组合物，血管紧张素转换酶抑制剂和用于预防或治疗血管疾病的药物组合物。 根据本发明，脱氢枞酸或衍生自松叶的通讯酸具有血管紧张素转化酶抑制活性，可作为消费者健康的有用组合物提供。 由于在本发明中具体提供了提取和分割方法，所以可以将作为具有高功能性的经济原料用作松果中大量含有的具有优异活性的材料。

公开(公告)号：KR101427384B1

公开(公告)日：2014-08-07

申请号：KR1020130026278

申请日：2013-03-12

Applicant: 조선대학교산학협력단

Inventor： 정현숙 ,  김성심 ,  박재영 ,  이범기 ,  최학준 ,  김웅

IPC: A23L1/30 ,  A61K31/185 ,  A61P7/02

CPC classification number: A23L33/10 ,  A23V2002/00 ,  A23V2200/326 ,  A61K31/185

Abstract: The present invention relates to a polyacrylic acid macromolecule having antithrombotic activity and to uses thereof. According to the present invention, when the polyacrylic acid macromolecules is used as an antithrombotic, blood clots in blood are degraded and removed. Consequently, factors for regenerating blood clots can be basically removed. Moreover, when blood is treated with the polyacrylic acid to be stored, substances, which coagulate blood, are removed at the starting point. Therefore, the polyacrylic acid macromolecule having antithrombotic activity can prevent blood coagulation and be used for developing artificial blood powder.

Abstract translation: 本发明涉及具有抗血栓形成活性的聚丙烯酸高分子及其应用。 根据本发明，当使用聚丙烯酸大分子作为抗血栓形成时，血液中的血块被降解和除去。 因此，可以基本上除去血块再生的因素。 此外，当用待储存的聚丙烯酸处理血液时，凝结血液的物质在起始点被去除。 因此，具有抗血栓活性的聚丙烯酸高分子可以防止血液凝结，并用于开发人造血粉。

公开(公告)号：KR101427381B1

公开(公告)日：2014-08-07

申请号：KR1020130026277

申请日：2013-03-12

Applicant: 조선대학교산학협력단

Inventor： 정현숙 ,  김성심 ,  박재영 ,  이범기 ,  최학준 ,  김웅

IPC: A23L1/30 ,  A23L2/38 ,  A61K31/19 ,  A61P7/02

CPC classification number: A23L33/10 ,  A23V2002/00 ,  A23V2200/30 ,  A61K31/19

Abstract: The present invention relates to a protocatechuic acid derivative having an antithrombotic activity and to a use thereof. An antithrombotic pharmaceutical composition according to the present invention can be applied to common beverages, dietary supplements, or medicine, thus is expected to be able to prevent and treat diseases involving thrombopoiesis such as arteriosclerosis, cerebral hemorrhage, stroke, or cerebral infarction.

Abstract translation: 本发明涉及具有抗血栓形成活性的原儿茶酸衍生物及其应用。 根据本发明的抗血栓药物组合物可以应用于普通饮料，膳食补充剂或药物，因此预期能够预防和治疗涉及血小板生成（例如动脉硬化，脑出血，中风或脑梗塞）的疾病。