公开(公告)号：KR100883815B1

公开(公告)日：2009-02-16

申请号：KR1020070094612

申请日：2007-09-18

Applicant: 조선대학교산학협력단

Inventor： 신송엽 ,  박가현 ,  함경수 ,  박윤경

IPC: A61K38/16 ,  A61P31/04

CPC classification number: Y02A50/481 ,  Y02A50/483 ,  A61K38/177 ,  A23L33/18 ,  A61K8/64 ,  A61Q17/005 ,  C07K14/705 ,  C12N15/113

Abstract: A model type antibiotic peptide to have abundant tryptophan is provided to show very low hemolytic activity in human RBC, to show very high bacterial cell specificity, to show high stability to human serum and to be usefully used as halogen free antimicrobial agent, food antiseptic and make-up additive. A synthesis or recombining antimicrobial peptide is selected from a group consisting of i) peptide selected from a group consisting of sequence number 1 to 4, ii) peptide in which lysine(Lys) is substituted for ornithine(Orn) from the peptide of i), iii) peptide in which leucine(Leu) is substituted for deer leucine(Nle) from the peptide of i) and iv) enantiomer peptide substituted for D-type amino acid corresponding all amino acids from the peptide of i) to iii). The peptide of ii) is written as sequence number 5.

Abstract translation: 提供了具有丰富色氨酸的模型型抗生素肽，以在人类RBC中显示非常低的溶血活性，显示出非常高的细菌细胞特异性，显示出对人血清的高度稳定性，并有效地用作无卤素抗微生物剂，食品防腐剂和 化妆添加剂。 合成或重组抗微生物肽选自i）选自序列号1至4的肽，ii）赖氨酸（Lys）取代来自i）的肽的鸟氨酸（Orn）的肽， ，iii）其中亮氨酸（Leu）从i）的肽替代鹿亮氨酸（Nle）的肽，和iv）取代相应于i）至iii）中所有肽的所有氨基酸的D型氨基酸的对映异构体肽。 ii）的肽序列号为5。