公开(公告)号：KR101936851B1

公开(公告)日：2019-01-11

申请号：KR1020120077013

申请日：2012-07-16

Applicant: 한국과학기술연구원

Inventor： 심태보 ,  노은주 ,  양한용

IPC: C07D471/04 ,  C07D231/56 ,  C07D401/12 ,  C07D409/12 ,  A61K31/437

公开(公告)号：KR1020140019055A

公开(公告)日：2014-02-14

申请号：KR1020120077013

申请日：2012-07-16

Applicant: 한국과학기술연구원

Inventor： 심태보 ,  노은주 ,  양한용

IPC: C07D471/04 ,  C07D403/12 ,  A61K31/437 ,  A61P35/00

Abstract: The present invention relates to novel pyrazolopyridine or indazole derivatives having inhibitory activity against protein kinases or pharmaceutically acceptable salts thereof. Since compounds of the present invention have excellent inhibitory activity against to protein kinases, for example, ABL, ACK1, ALK, Aurora A, Aurora B, Aurora C, BLK, BMX/ETK, BRSK1, BTK, c-Src, CAMKK, CDK1, CDK2, CDK5, CLK, DDR, DYRK1B, EPHA, EPHB, FAK/PTK2, FER, FES/FPS, FGFR, FGR, FLT3, FLT4/VEGFR3, FMS, FRK/PTK5, FYN, GSK3b, HCK, IGF1R, IR, IRAK1, IRR/INSRR, ITK, JAK2, KHS/MAP4K5, LCK, LYN, PHKg, PLK4/SAK, PYK2, RET, ROS/ROS1, TIE2/TEK, TRK, TXK, TYK, YES/YES1, and the like, the compounds are useful for treatment and prevention of various kinds of cancer diseases.

Abstract translation: 本发明涉及对蛋白激酶具有抑制活性的新的吡唑并吡啶或吲唑衍生物或其药学上可接受的盐。 由于本发明的化合物对蛋白激酶例如ABL，ACK1，ALK，Aurora A，Aurora B，Aurora C，BLK，BMX / ETK，BRSK1，BTK，c-Src，CAMKK，CDK1具有优异的抑制活性 ，CDK2，CDK5，CLK，DDR，DYRK1B，EPHA，EPHB，FAK / PTK2，FER，FES / FPS，FGFR，FGR，FLT3，FLT4 / VEGFR3，FMS，FRK / PTK5，FYN，GSK3b，HCK，IGF1R， ，IRAK1，IRR / INSRR，ITK，JAK2，KHS / MAP4K5，LCK，LYN，PHKg，PLK4 / SAK，PYK2，RET，ROS / ROS1，TIE2 / TEK，TRK，TXK，TYK，YES / YES1等 ，这些化合物可用于治疗和预防各种癌症疾病。