公开(公告)号：WO2014163939A3

公开(公告)日：2014-11-27

申请号：PCT/US2014019079

申请日：2014-02-27

Applicant: 1ST DETECT CORP

Inventor： RAFFERTY DAVID ,  SPENCER MICHAEL

IPC: H01J49/42 ,  H01J3/00 ,  H01J3/02 ,  H01J49/02

CPC classification number: H01J49/02 ,  H01J49/424 ,  H01J49/4255

Abstract: An ion trap for a mass spectrometer is disclosed. The ion trap includes a ring electrode and first and second electrodes which are arranged on opposite sides of the ring electrode. The ring electrode and the first and second electrodes are configured to generate an electric field based on the received RF signal. The first electrode defines a first aperture and the second electrode defines a second aperture, the first aperture and the second aperture being asymmetric relative to each other and configured to generate a hexapoie field.

Abstract translation: 公开了用于质谱仪的离子阱。 离子阱包括环形电极和布置在环形电极的相对侧上的第一和第二电极。 环形电极和第一和第二电极被配置为基于所接收的RF信号产生电场。 第一电极限定第一孔，并且第二电极限定第二孔，第一孔和第二孔相对于彼此是不对称的并且被配置成产生六面体场。

公开(公告)号：WO2014149846A2

公开(公告)日：2014-09-25

申请号：PCT/US2014021188

申请日：2014-03-06

Applicant: 1ST DETECT CORP

Inventor： RAFFERTY DAVID ,  SPENCER MICHAEL

CPC classification number: H01J49/147 ,  H01J49/0013 ,  H01J49/025 ,  H01J49/24 ,  H01J49/424

Abstract: A mass spectrometer system is disclosed. The mass spectrometer includes a vacuum chamber defining an enclosed evacuated space and an ion trap disposed in the enclosed space. The ion trap is configured to trap an ionized sample. The mass spectrometer further includes an son detector coupled to the chamber at a location external to the chamber such that sample ions may exit the evacuated space and into the externally-coupled detector without loss of vacuum pressure.

Abstract translation: 公开了一种质谱仪系统。 质谱仪包括限定封闭空间的真空室和设置在封闭空间中的离子阱。 离子阱被配置成捕获电离样品。 质谱仪还包括在室外部位置耦合到室的儿子检测器，使得样品离子可以离开真空空间并进入外部耦合检测器而不损失真空压力。

公开(公告)号：WO2014163939A8

公开(公告)日：2015-01-08

申请号：PCT/US2014019079

申请日：2014-02-27

Applicant: 1ST DETECT CORP

Inventor： RAFFERTY DAVID ,  SPENCER MICHAEL

IPC: H01J49/42 ,  H01J3/00 ,  H01J3/02 ,  H01J49/02

CPC classification number: H01J49/02 ,  H01J49/424 ,  H01J49/4255

Abstract: An ion trap for a mass spectrometer is disclosed. The ion trap includes a ring electrode and first and second electrodes which are arranged on opposite sides of the ring electrode. The ring electrode and the first and second electrodes are configured to generate an electric field based on the received RF signal. The first electrode defines a first aperture and the second electrode defines a second aperture, the first aperture and the second aperture being asymmetric relative to each other and configured to generate a hexapole field.

Abstract translation: 公开了用于质谱仪的离子阱。 离子阱包括环形电极和布置在环形电极的相对侧上的第一和第二电极。 环形电极和第一和第二电极被配置为基于所接收的RF信号产生电场。 第一电极限定第一孔，并且第二电极限定第二孔，第一孔和第二孔相对于彼此是不对称的并且被配置成产生六极场。

公开(公告)号：WO2014144667A3

公开(公告)日：2015-01-08

申请号：PCT/US2014029175

申请日：2014-03-14

Applicant: 1ST DETECT CORP

Inventor： RAFFERTY DAVID ,  SPENCER MICHAEL

IPC: H01J49/42 ,  H01J49/00 ,  H01J49/04

CPC classification number: H01J49/06 ,  H01J49/0013 ,  H01J49/0031 ,  H01J49/0481 ,  H01J49/424

Abstract: Apparatuses and methods for performing mass analysis are disclosed. One such apparatus may include an ion trap device. The ion trap device may comprise a first end cap having a first aperture and a second end cap having a second aperture, wherein the first aperture and the second aperture may define an ejection axis. The ion trap device may also comprise a ring electrode substantially coaxially aligned between the first and second end caps. The ring electrode may include an opening extending along a radial direction of the ring electrode, wherein the radial direction is substantially perpendicular to the ejection axis. One such method may include ionizing a sample in an ion trap through an opening separating at least part of first and second ring sections of the ion trap and detecting ions ejected though an aperture on an end cap of the ion trap.

Abstract translation: 公开了用于进行质量分析的装置和方法。 一种这样的装置可以包括离子阱装置。 离子阱装置可以包括具有第一孔的第一端盖和具有第二孔的第二端盖，其中第一孔和第二孔可以限定喷射轴线。 离子阱装置还可以包括在第一和第二端盖之间大致同轴对准的环形电极。 环形电极可以包括沿着环形电极的径向方向延伸的开口，其中径向基本上垂直于喷射轴线。 一种这样的方法可以包括通过分离离子阱的第一和第二环部分的至少一部分并检测通过离子阱的端盖上的孔喷射的离子的开口离子化离子阱中的样品。

公开(公告)号：WO2014164198A8

公开(公告)日：2014-12-31

申请号：PCT/US2014021184

申请日：2014-03-06

Applicant: 1ST DETECT CORP

Inventor： RAFFERTY DAVID ,  SPENCER MICHAEL ,  WYLDE JAMES ,  GARDNER DAVID LORENZ ,  MINO WARREN

IPC: H01J49/14 ,  H01J49/06 ,  H01J49/42

CPC classification number: H01J49/147 ,  H01J49/0013 ,  H01J49/0031 ,  H01J49/067 ,  H01J49/424 ,  H01J49/4265

Abstract: In mass spectrometry, the number of ionized sample molecules affects various performance specifications of the resulting spectrum, including resolution, sensitivity, dynamic range, and scan speed. A voltage-controlled lens is used to control the number of electrons emitted from an electron source that enter the ion trap and ionize the target sample molecules. By monitoring a feature of the resulting spectrum, such as the resolution, total ion current, or a combination of these features, the lens voltage may be adjusted to create the optimal number of ions in the trap for a particular sample spectrum scan. Generally, for low concentration samples, the number of electrons introduced to the trap is increased, hence creating more ions in the trap, which in turn increases the intensity of the output signal improving the probability of detecting a sufficient number of ions by raising the intensity well above the noise floor. For higher concentration samples, the number of electrons is reduced, thus reducing interactions in the trap which in turn reduces peak broadening and improves resolution, as well as avoids saturating the detector. Several methods for adjusting the lens voltage may be used. First, the lens voltage may be repeatedly adjusted until the resulting spectrum reaches a desired trade-off between resolution and sensitivity. The lens voltage may also be incrementally increased until the resulting spectrum begins to exhibit space charge effects. Finally, all lens voltages in a list of usable voltage settings may be applied, and all the resulting spectra are compared. The optimal voltage setting is selected and used for subsequent scans.

Abstract translation: 在质谱中，电离样品分子的数量影响所得光谱的各种性能规格，包括分辨率，灵敏度，动态范围和扫描速度。 电压控制透镜用于控制从进入离子阱的电子源发射的电子数，并使目标样品分子离子化。 通过监测所得光谱的特征，例如分辨率，总离子电流或这些特征的组合，可以调整透镜电压以在特定样品光谱扫描中产生陷阱中的最佳离子数。 通常，对于低浓度样品，引入陷阱的电子数量增加，从而在阱中产生更多的离子，这反过来增加了输出信号的强度，从而提高了通过提高强度来检测足够数量的离子的概率 远高于本底噪音。 对于较高浓度的样品，电子数量减少，从而减少陷阱中的相互作用，从而降低峰值变宽并提高分辨率，并避免检测器饱和。 可以使用用于调整透镜电压的几种方法。 首先，可以重复调整透镜电压，直到得到的光谱在分辨率和灵敏度之间达到期望的折衷。 透镜电压也可以递增地增加，直到得到的光谱开始显示空间电荷效应。 最后，可以应用可用电压设置列表中的所有透镜电压，并比较所有得到的光谱。 选择最佳电压设置并用于后续扫描。

公开(公告)号：CA2824525A1

公开(公告)日：2012-07-19

申请号：CA2824525

申请日：2012-01-11

Applicant: 1ST DETECT CORP

Inventor： RAFFERTY DAVID ,  WYLDE JAMES ,  SPENCER MICHAEL ,  OJEDA PEDRO ,  BOWDEN THOMAS

IPC: H01J49/04 ,  G01N1/40

Abstract: In one general aspect, a sample is transferred into a mass spectrometer (150) by capturing a sample on a collector (125), inserting the collector (125) into a sample chamber (110) coupled to the mass spectrometer (150) and a vacuum pump (342, 344), evacuating the sample chamber (110) using the vacuum pump (342, 344) to reduce an internal pressure of the sample chamber (110) to a level less than atmospheric pressure, heating the collector (125) to release the sample from the collector, and introducing the sample into the mass spectrometer (150) from the evacuated sample chamber (110).

公开(公告)号：AU2010292492A1

公开(公告)日：2012-03-29

申请号：AU2010292492

申请日：2010-08-27

Applicant: 1ST DETECT CORP

Inventor： OJEDA PEDRO ,  RAFFERTY DAVID ,  SPENCER MICHAEL ,  WYLDE JAMES

IPC: G01N1/40

Abstract: A chemical analysis system is disclosed wherein, in evacuating a preconcentrator housing (2) prior to desorption, a pump system (13) reduces an internal pressure of the preconcentrator housing to a level substantially equal to an internal pressure of a chemical analyzer such that flow restrictors and/or membranes (15) between the chemical analyzer (7) and the preconcentrator housing (2) may be omitted. The chemical analysis system includes a chemical analyzer (7), a preconcentrator housing (2) coupled to the chemical analyzer, the preconcentrator housing enclosing a temperature control element (5, 18) and a sorbent material (1), the temperature control element configured to heat the sorbent material to adsorb or desorb a chemical of interest; and a pump system (13) coupled to the preconcentrator housing and the chemical analyzer, the pump system configured to evacuate the preconcentrator housing prior to desorption of the chemical of interest.

公开(公告)号：CA2772319A1

公开(公告)日：2011-03-17

申请号：CA2772319

申请日：2010-08-27

Applicant: 1ST DETECT CORP

Inventor： OJEDA PEDRO ,  RAFFERTY DAVID ,  SPENCER MICHAEL ,  WYLDE JAMES

IPC: G01N1/40

Abstract: A chemical analysis system is disclosed wherein, in evacuating a preconcentrator housing (2) prior to desorption, a pump system (13) reduces an internal pressure of the preconcentrator housing to a level substantially equal to an internal pressure of a chemical analyzer such that flow restrictors and/or membranes (15) between the chemical analyzer (7) and the preconcentrator housing (2) may be omitted. The chemical analysis system includes a chemical analyzer (7), a preconcentrator housing (2) coupled to the chemical analyzer, the preconcentrator housing enclosing a temperature control element (5, 18) and a sorbent material (1), the temperature control element configured to heat the sorbent material to adsorb or desorb a chemical of interest; and a pump system (13) coupled to the preconcentrator housing and the chemical analyzer, the pump system configured to evacuate the preconcentrator housing prior to desorption of the chemical of interest.

公开(公告)号：CA2826873C

公开(公告)日：2019-04-02

申请号：CA2826873

申请日：2012-02-07

Applicant: 1ST DETECT CORP

Inventor： RAFFERTY DAVID ,  SPENCER MICHAEL ,  WYLDE JAMES ,  OJEDA PEDRO ,  BOWDEN THOMAS

IPC: G01N1/40

Abstract: A chemical preconcentrator (100) includes a conduit (200) defining a flow path (106) between two ends (108A, 108B) and having a heating element (102) disposed within the conduit, such that the heating element has at least one sorbent material (115) deposited directly on at least a portion of a conductive surface of the heating element. Some such heating elements (102) are in the form of electrically conductive strips defining both a plurality of apertures (112, 710) through the strip and a series of undulations (114) spaced along the flow path (106).

公开(公告)号：CA2824525C

公开(公告)日：2017-07-04

申请号：CA2824525

申请日：2012-01-11

Applicant: 1ST DETECT CORP

Inventor： RAFFERTY DAVID ,  WYLDE JAMES ,  SPENCER MICHAEL ,  OJEDA PEDRO

IPC: H01J49/04 ,  G01N1/40

Abstract: In one general aspect, a sample is transferred into a mass spectrometer (150) by capturing a sample on a collector (125), inserting the collector (125) into a sample chamber (110) coupled to the mass spectrometer (150) and a vacuum pump (342, 344), evacuating the sample chamber (110) using the vacuum pump (342, 344) to reduce an internal pressure of the sample chamber (110) to a level less than atmospheric pressure, heating the collector (125) to release the sample from the collector, and introducing the sample into the mass spectrometer (150) from the evacuated sample chamber (110).