公开(公告)号：WO2014164198A8

公开(公告)日：2014-12-31

申请号：PCT/US2014021184

申请日：2014-03-06

Applicant: 1ST DETECT CORP

Inventor： RAFFERTY DAVID ,  SPENCER MICHAEL ,  WYLDE JAMES ,  GARDNER DAVID LORENZ ,  MINO WARREN

IPC: H01J49/14 ,  H01J49/06 ,  H01J49/42

CPC classification number: H01J49/147 ,  H01J49/0013 ,  H01J49/0031 ,  H01J49/067 ,  H01J49/424 ,  H01J49/4265

Abstract: In mass spectrometry, the number of ionized sample molecules affects various performance specifications of the resulting spectrum, including resolution, sensitivity, dynamic range, and scan speed. A voltage-controlled lens is used to control the number of electrons emitted from an electron source that enter the ion trap and ionize the target sample molecules. By monitoring a feature of the resulting spectrum, such as the resolution, total ion current, or a combination of these features, the lens voltage may be adjusted to create the optimal number of ions in the trap for a particular sample spectrum scan. Generally, for low concentration samples, the number of electrons introduced to the trap is increased, hence creating more ions in the trap, which in turn increases the intensity of the output signal improving the probability of detecting a sufficient number of ions by raising the intensity well above the noise floor. For higher concentration samples, the number of electrons is reduced, thus reducing interactions in the trap which in turn reduces peak broadening and improves resolution, as well as avoids saturating the detector. Several methods for adjusting the lens voltage may be used. First, the lens voltage may be repeatedly adjusted until the resulting spectrum reaches a desired trade-off between resolution and sensitivity. The lens voltage may also be incrementally increased until the resulting spectrum begins to exhibit space charge effects. Finally, all lens voltages in a list of usable voltage settings may be applied, and all the resulting spectra are compared. The optimal voltage setting is selected and used for subsequent scans.

Abstract translation: 在质谱中，电离样品分子的数量影响所得光谱的各种性能规格，包括分辨率，灵敏度，动态范围和扫描速度。 电压控制透镜用于控制从进入离子阱的电子源发射的电子数，并使目标样品分子离子化。 通过监测所得光谱的特征，例如分辨率，总离子电流或这些特征的组合，可以调整透镜电压以在特定样品光谱扫描中产生陷阱中的最佳离子数。 通常，对于低浓度样品，引入陷阱的电子数量增加，从而在阱中产生更多的离子，这反过来增加了输出信号的强度，从而提高了通过提高强度来检测足够数量的离子的概率 远高于本底噪音。 对于较高浓度的样品，电子数量减少，从而减少陷阱中的相互作用，从而降低峰值变宽并提高分辨率，并避免检测器饱和。 可以使用用于调整透镜电压的几种方法。 首先，可以重复调整透镜电压，直到得到的光谱在分辨率和灵敏度之间达到期望的折衷。 透镜电压也可以递增地增加，直到得到的光谱开始显示空间电荷效应。 最后，可以应用可用电压设置列表中的所有透镜电压，并比较所有得到的光谱。 选择最佳电压设置并用于后续扫描。

公开(公告)号：WO2014163940A3

公开(公告)日：2014-11-27

申请号：PCT/US2014019085

申请日：2014-02-27

Applicant: 1ST DETECT CORP

Inventor： RAFFERTY DAVID

IPC: H01J49/42 ,  H01J49/00

CPC classification number: H01J49/0031 ,  H01J49/424 ,  H01J49/4295

Abstract: A mass spectrometer for analyzing a sample utilizing an ion trap comprises an entrance end cap defining an entrance aperture configured to receive the sample entering the ion trap; a ring electrode defining a ring cavity configured to generate, based on a radio frequency (RF) voltage applied to the ring electrode, an electric field configured to trap the sample received through the entrance aperture; an exit end cap defining an exit aperture configured to receive sample ions exiting the ion trap; and an end cap controller configured to generate a bias control voltage for applying a DC bias potential to at least one of the entrance end or the exit end cap, wherein a value of the bias control voltage is based on an operational parameter of the mass spectrometer.

Abstract translation: 用于利用离子阱来分析样品的质谱仪包括：入口端盖，其限定入口孔，入口孔被配置为接收进入离子阱的样品; 环形电极，所述环形电极限定环形腔，所述环形腔被配置为基于施加到所述环形电极的射频（RF）电压来产生电场，所述电场被配置为捕获通过所述入口孔接收的所述样本; 出口端盖，其限定出口孔，所述出口孔被配置为接收离开所述离子阱的样品离子; 以及端盖控制器，所述端盖控制器被配置为产生用于向所述入口端或所述出口端盖中的至少一个施加直流偏置电位的偏置控制电压，其中，所述偏置控制电压的值基于所述质谱仪的操作参数 。

公开(公告)号：WO2014163767A3

公开(公告)日：2015-01-08

申请号：PCT/US2014015956

申请日：2014-02-12

Applicant: 1ST DETECT CORP

Inventor： RAFFERTY DAVID ,  OLIVER BRIAN ,  BLACK DARRON

IPC: H01J49/00 ,  H01J49/42

CPC classification number: H01J49/0009 ,  H01J49/424

Abstract: A mass spectrometer comprises an ion trap configured to trap ions and to eject ions. The ion trap comprises an e!ectrode. The mass spectrometer further comprises a detector configured to detect ions ejected from the ion trap, a radio frequency (RF) generator electrically coupled to the electrode and configured to generate an RF signal, a sampling circuit electrically coupled to electrode and configured to measure a voltage of the RF signal at the electrode, and a signal processor electrically coupled to the sampling circuit and the detector. The signal processor is configured to receive outputs from the detector and the sampling circuit and to correct the output from the detector based on the output from the sampling circuit.

Abstract translation: 质谱仪包括被配置成捕获离子并排出离子的离子阱。 离子阱包括电极。 所述质谱仪还包括检测器，其被配置为检测从所述离子阱排出的离子;射频（RF）发生器，其电耦合到所述电极并被配置为产生RF信号;采样电路，电耦合到电极并且被配置为测量电压 的电极处的RF信号，以及电耦合到采样电路和检测器的信号处理器。 信号处理器被配置为从检测器和采样电路接收输出，并且基于来自采样电路的输出来校正来自检测器的输出。

公开(公告)号：WO2014163939A3

公开(公告)日：2014-11-27

申请号：PCT/US2014019079

申请日：2014-02-27

Applicant: 1ST DETECT CORP

Inventor： RAFFERTY DAVID ,  SPENCER MICHAEL

IPC: H01J49/42 ,  H01J3/00 ,  H01J3/02 ,  H01J49/02

CPC classification number: H01J49/02 ,  H01J49/424 ,  H01J49/4255

Abstract: An ion trap for a mass spectrometer is disclosed. The ion trap includes a ring electrode and first and second electrodes which are arranged on opposite sides of the ring electrode. The ring electrode and the first and second electrodes are configured to generate an electric field based on the received RF signal. The first electrode defines a first aperture and the second electrode defines a second aperture, the first aperture and the second aperture being asymmetric relative to each other and configured to generate a hexapoie field.

Abstract translation: 公开了用于质谱仪的离子阱。 离子阱包括环形电极和布置在环形电极的相对侧上的第一和第二电极。 环形电极和第一和第二电极被配置为基于所接收的RF信号产生电场。 第一电极限定第一孔，并且第二电极限定第二孔，第一孔和第二孔相对于彼此是不对称的并且被配置成产生六面体场。

公开(公告)号：WO2014149846A2

公开(公告)日：2014-09-25

申请号：PCT/US2014021188

申请日：2014-03-06

Applicant: 1ST DETECT CORP

Inventor： RAFFERTY DAVID ,  SPENCER MICHAEL

CPC classification number: H01J49/147 ,  H01J49/0013 ,  H01J49/025 ,  H01J49/24 ,  H01J49/424

Abstract: A mass spectrometer system is disclosed. The mass spectrometer includes a vacuum chamber defining an enclosed evacuated space and an ion trap disposed in the enclosed space. The ion trap is configured to trap an ionized sample. The mass spectrometer further includes an son detector coupled to the chamber at a location external to the chamber such that sample ions may exit the evacuated space and into the externally-coupled detector without loss of vacuum pressure.

Abstract translation: 公开了一种质谱仪系统。 质谱仪包括限定封闭空间的真空室和设置在封闭空间中的离子阱。 离子阱被配置成捕获电离样品。 质谱仪还包括在室外部位置耦合到室的儿子检测器，使得样品离子可以离开真空空间并进入外部耦合检测器而不损失真空压力。

公开(公告)号：WO2014163939A8

公开(公告)日：2015-01-08

申请号：PCT/US2014019079

申请日：2014-02-27

Applicant: 1ST DETECT CORP

Inventor： RAFFERTY DAVID ,  SPENCER MICHAEL

IPC: H01J49/42 ,  H01J3/00 ,  H01J3/02 ,  H01J49/02

CPC classification number: H01J49/02 ,  H01J49/424 ,  H01J49/4255

Abstract: An ion trap for a mass spectrometer is disclosed. The ion trap includes a ring electrode and first and second electrodes which are arranged on opposite sides of the ring electrode. The ring electrode and the first and second electrodes are configured to generate an electric field based on the received RF signal. The first electrode defines a first aperture and the second electrode defines a second aperture, the first aperture and the second aperture being asymmetric relative to each other and configured to generate a hexapole field.

Abstract translation: 公开了用于质谱仪的离子阱。 离子阱包括环形电极和布置在环形电极的相对侧上的第一和第二电极。 环形电极和第一和第二电极被配置为基于所接收的RF信号产生电场。 第一电极限定第一孔，并且第二电极限定第二孔，第一孔和第二孔相对于彼此是不对称的并且被配置成产生六极场。

公开(公告)号：WO2014144667A3

公开(公告)日：2015-01-08

申请号：PCT/US2014029175

申请日：2014-03-14

Applicant: 1ST DETECT CORP

Inventor： RAFFERTY DAVID ,  SPENCER MICHAEL

IPC: H01J49/42 ,  H01J49/00 ,  H01J49/04

CPC classification number: H01J49/06 ,  H01J49/0013 ,  H01J49/0031 ,  H01J49/0481 ,  H01J49/424

Abstract: Apparatuses and methods for performing mass analysis are disclosed. One such apparatus may include an ion trap device. The ion trap device may comprise a first end cap having a first aperture and a second end cap having a second aperture, wherein the first aperture and the second aperture may define an ejection axis. The ion trap device may also comprise a ring electrode substantially coaxially aligned between the first and second end caps. The ring electrode may include an opening extending along a radial direction of the ring electrode, wherein the radial direction is substantially perpendicular to the ejection axis. One such method may include ionizing a sample in an ion trap through an opening separating at least part of first and second ring sections of the ion trap and detecting ions ejected though an aperture on an end cap of the ion trap.

Abstract translation: 公开了用于进行质量分析的装置和方法。 一种这样的装置可以包括离子阱装置。 离子阱装置可以包括具有第一孔的第一端盖和具有第二孔的第二端盖，其中第一孔和第二孔可以限定喷射轴线。 离子阱装置还可以包括在第一和第二端盖之间大致同轴对准的环形电极。 环形电极可以包括沿着环形电极的径向方向延伸的开口，其中径向基本上垂直于喷射轴线。 一种这样的方法可以包括通过分离离子阱的第一和第二环部分的至少一部分并检测通过离子阱的端盖上的孔喷射的离子的开口离子化离子阱中的样品。

公开(公告)号：WO2014163941A3

公开(公告)日：2014-12-31

申请号：PCT/US2014019090

申请日：2014-02-27

Applicant: 1ST DETECT CORP

Inventor： RAFFERTY DAVID ,  GARDNER DAVID LORENZ ,  WYLDE JAMES

IPC: H01J49/02 ,  H01J49/00 ,  H01J49/36

CPC classification number: H01J49/0031 ,  G06K9/0051 ,  H01J49/022 ,  H01J49/025 ,  H01J49/429

Abstract: A mass spectrometer comprising a controller configured to generate an RF signal to be applied to an electrode during the mass scan, wherein the electrode generates, based on the RF signal, an electric field to be applied to sample ions during a mass scan; an ion detector configured to detect sample ions passing through the electric field and generate a corresponding ion detection signal; and a sampling circuit configured to sample the ion detection signal; wherein the controller is configured to adjust a phase of the at least one RF signal relative to a sample timing of the sampling circuit and average successive mass scans to cancel a portion of the RF signal present in the ion detection signal.

Abstract translation: 一种质谱仪，包括控制器，所述控制器被配置成在所述质量扫描期间产生将被施加到电极的RF信号，其中所述电极基于所述RF信号在质量扫描期间产生要施加到样品离子的电场; 离子检测器，配置成检测通过电场的样本离子并产生相应的离子检测信号; 以及采样电路，被配置为采样所述离子检测信号; 其中所述控制器被配置为调整所述至少一个RF信号相对于所述采样电路的采样定时的相位和平均连续质量扫描以消除所述离子检测信号中存在的RF信号的一部分。

公开(公告)号：HK1155850A1

公开(公告)日：2012-05-25

申请号：HK11109887

申请日：2011-09-20

Applicant: 1ST DETECT CORP

Inventor： RAFFERTY DAVID

IPC: H01J20060101

公开(公告)号：CA2956171A1

公开(公告)日：2016-01-28

申请号：CA2956171

申请日：2015-07-23

Applicant: 1ST DETECT CORP

Inventor： RAFFERTY DAVID ,  JOHNSON LOUIS

IPC: H01J49/26

Abstract: Apparatuses, systems, and methods for performing mass analysis are disclosed. One such apparatus may include an ion trap device for use in a mass analysis system. The ion trap device may comprise a ring electrode, a pair of endcaps, and a signal generator for applying a trapping signal to the ring electrode. The trapping signal may be configured to cause the ring electrode to generate an electric field. The signal generator may include a plurality of oscillators each configured to selectively generate a corresponding sinusoid signal to be selectively combined to form the trapping signal.