公开(公告)号：EP0663912A1

公开(公告)日：1995-07-26

申请号：EP93923826.0

申请日：1993-10-08

Applicant: ABBOTT LABORATORIES

Inventor： ABREO, Melwyn A. ,  GUNN, David E. ,  LIN, Nan-Horng ,  ELLIOTT, Richard L. ,  GARVEY, David S. ,  LEBOLD, Suzanne A. ,  WASICAK, James T.

IPC: A61K31 ,  A61P25 ,  C07D401 ,  C07D403 ,  C07D411 ,  C07D417 ,  C07D471 ,  C07D487

CPC classification number: C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: Novel heterocyclic ether compounds of formula (I), wherein A, B and R2 are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are selective and potent ligands at cholinergic channel receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.

公开(公告)号：EP0588917A1

公开(公告)日：1994-03-30

申请号：EP92912971.0

申请日：1992-05-28

Applicant: ABBOTT LABORATORIES

Inventor： GARVEY, David S. ,  CARRERA, George M., Jr. ,  ARNERIC, Stephen P. ,  SHUE, Youe-Kong ,  LIN, Nan-Horng ,  HE, Yun

IPC: A61K31 ,  A61P25 ,  C07D401 ,  C07D403 ,  C07D413 ,  C07D417

CPC classification number: C07D417/04 ,  C07D413/04

Abstract: Agonistes nicotiniques, sélectifs et puissants, de la formule (I), ou sels pharmaceutiquement acceptables de ceux-ci, utilisés dans le traitement de troubles mentaux, neurologiques et cognitifs caractérisés par une diminution des fonctions cholinergiques.

公开(公告)号：EP0588917B1

公开(公告)日：2000-11-08

申请号：EP92912971.6

申请日：1992-05-28

Applicant: ABBOTT LABORATORIES

Inventor： GARVEY, David S. ,  CARRERA, George M., Jr. ,  ARNERIC, Stephen P. ,  SHUE, Youe-Kong ,  LIN, Nan-Horng ,  HE, Yun

IPC: C07D413/04 ,  C07D417/04 ,  A61K31/425 ,  A61K31/42

CPC classification number: C07D417/04 ,  C07D413/04

Abstract: Selective and potent nicotinic agonists of formula (I), or pharmaceutically-acceptable salts thereof, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.

公开(公告)号：EP0663912B1

公开(公告)日：2001-12-12

申请号：EP93923826.7

申请日：1993-10-08

Applicant: ABBOTT LABORATORIES

Inventor： ABREO, Melwyn A. ,  GUNN, David E. ,  LIN, Nan-Horng ,  ELLIOTT, Richard L. ,  GARVEY, David S. ,  LEBOLD, Suzanne A. ,  WASICAK, James T.

IPC: C07D401/12 ,  C07D403/12 ,  C07D411/12 ,  A61K31/425 ,  A61K31/44 ,  A61K31/445 ,  A61K31/47 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  C07D417/12 ,  C07D487/04 ,  C07D453/02

CPC classification number: C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: Novel heterocyclic ether compounds of formula (I), wherein A, B and R2 are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are selective and potent ligands at cholinergic channel receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.