公开(公告)号：WO1997046881A1

公开(公告)日：1997-12-11

申请号：PCT/US1997009429

申请日：1997-06-03

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  POPE, Mark, R. ,  TARCHA, Peter, J. ,  MEES, David, R. ,  JOSEPH, Mary, K. ,  PRY, Terry, A. ,  PUTMAN, C., Brent ,  SUBOTICH, Daniel, T.

IPC: G01N33/543

CPC classification number: G01N33/54393 ,  G01N33/54353 ,  Y10S435/962 ,  Y10S435/963 ,  Y10S436/81 ,  Y10S436/823

Abstract: A method for increasing the binding activity of specific binding members bound to a solid phase material, e.g., a particle, that has been sterically stabilized. This increase in binding activity is brought about by degrading a steric stabilizer on the surface of the solid phase material. The method involves both immobilizing a specific binding member on the surface of a solid phase material and degrading a steric stabilizer on the surface of that solid phase material. In the preferred embodiment, the method involves the immobilization of a specific binding member on the surface of the sterically stabilized solid phase material, with subsequent degradation of the steric stabilizer.

Abstract translation: 用于增加与已经空间稳定的固相物质例如颗粒结合的特异性结合成员的结合活性的方法。 结合活性的这种增加是通过降解固相材料表面上的空间稳定剂引起的。 该方法包括将特定的结合构件固定在固相材料的表面上并降解固相材料表面上的空间稳定剂。 在优选的实施方案中，该方法包括将特定结合成分固定在空间稳定的固相材料的表面上，随后空间稳定剂的降解。

公开(公告)号：EP0923735A1

公开(公告)日：1999-06-23

申请号：EP97926857.0

申请日：1997-06-03

Applicant: Abbott Laboratories

Inventor： POPE, Mark, R. ,  TARCHA, Peter, J. ,  MEES, David, R. ,  JOSEPH, Mary, K. ,  PRY, Terry, A. ,  PUTMAN, C., Brent ,  SUBOTICH, Daniel, T.

IPC: G01N33

CPC classification number: G01N33/54393 ,  G01N33/54353 ,  Y10S435/962 ,  Y10S435/963 ,  Y10S436/81 ,  Y10S436/823

Abstract: A method for increasing the binding activity of specific binding members bound to a solid phase material, e.g., a particle, that has been sterically stabilized. This increase in binding activity is brought about by degrading a steric stabilizer on the surface of the solid phase material. The method involves both immobilizing a specific binding member on the surface of a solid phase material and degrading a steric stabilizer on the surface of that solid phase material. In the preferred embodiment, the method involves the immobilization of a specific binding member on the surface of the sterically stabilized solid phase material, with subsequent degradation of the steric stabilizer.

公开(公告)号：EP0923735B1

公开(公告)日：2002-08-28

申请号：EP97926857.0

申请日：1997-06-03

Applicant: Abbott Laboratories

Inventor： POPE, Mark, R. ,  TARCHA, Peter, J. ,  MEES, David, R. ,  JOSEPH, Mary, K. ,  PRY, Terry, A. ,  PUTMAN, C., Brent ,  SUBOTICH, Daniel, T.

IPC: G01N33/543 ,  G01N33/545 ,  G01N33/546

CPC classification number: G01N33/54393 ,  G01N33/54353 ,  Y10S435/962 ,  Y10S435/963 ,  Y10S436/81 ,  Y10S436/823

Abstract: A method for increasing the binding activity of specific binding members bound to a solid phase material, e.g., a particle, that has been sterically stabilized. This increase in binding activity is brought about by degrading a steric stabilizer on the surface of the solid phase material. The method involves both immobilizing a specific binding member on the surface of a solid phase material and degrading a steric stabilizer on the surface of that solid phase material. In the preferred embodiment, the method involves the immobilization of a specific binding member on the surface of the sterically stabilized solid phase material, with subsequent degradation of the steric stabilizer.