公开(公告)号：CA3036690C

公开(公告)日：2022-08-09

申请号：CA3036690

申请日：2017-09-13

Applicant: ACADEMIA SINICA ,  SHEN CHE KUN JAMES ,  SHYU YU CHIAU ,  HUNG CHUN HAO

Inventor： SHEN CHE-KUN JAMES ,  SHYU YU-CHIAU ,  HUNG CHUN-HAO

IPC: A61K38/16 ,  C07K14/47 ,  C12N5/095

Abstract: The invention found that first, the feasibility of transfer of tumor resistance and other healthy longevity characters through transplantation of bone marrow mononuclear cells (BMMNC) or hematopoietic stem cells (HSC)/hematopoietic stem and progenitor cells (HSPC) consisting of genetically engineered EKLF gene encoding the hematopoietic transcription factor EKLF. Secondly, the present invention demonstrates expression of EKLF in the long-term hematopoietic stem cells (LT-HSC), and thus EKLF as a target of regulation of hematopoiesis.

公开(公告)号：CA2959522C

公开(公告)日：2021-09-07

申请号：CA2959522

申请日：2015-09-01

Applicant: ACADEMIA SINICA

Inventor： SHEN CHE-KUN JAMES ,  SHYU YU-CHIAU

IPC: C12N15/85 ,  A01K67/027 ,  A61K31/7088 ,  A61K38/16 ,  A61P35/00 ,  C07K14/47 ,  C12N5/10 ,  C12N15/12 ,  C12Q1/00

Abstract: The present invention includes a genetically-modified non-human animal model of longevity and increased health span, which is associated with reduced tumorigenesis and tumor metastasis, as well as related methods for increasing longevity and health span, reducing tumorigenesis and tumor metastasis, and identifying active agents that confer increased longevity or health span, or reduced tumorigenesis or tumor metastasis

公开(公告)号：AU2018211345B2

公开(公告)日：2019-10-31

申请号：AU2018211345

申请日：2018-08-03

Applicant: ACADEMIA SINICA

Inventor： SHYU YU-CHIAU ,  SHEN CHE-KUN JAMES

IPC: A01N63/00 ,  C12N5/00 ,  C12N15/00

Abstract: Abstract The present invention includes a genetically-modified non-human animal model of longevity and increased health span, which is associated with 5 reduced tumorigenesis and tumor metastasis, as well as related methods for increasing longevity and health span, reducing tumorigenesis and tumor metastasis, and identifying active agents that confer increased longevity or health span, or reduced tumorigenesis or tumor metastasis.

公开(公告)号：AU2017326234B2

公开(公告)日：2020-05-14

申请号：AU2017326234

申请日：2017-09-13

Applicant: ACADEMIA SINICA

Inventor： SHEN CHE-KUN JAMES ,  SHYU YU-CHIAU ,  HUNG CHUN-HAO

IPC: C07K14/47 ,  A61K38/16 ,  C12N5/095

Abstract: The invention found that first, the feasibility of transfer of tumor resistance and other healthy longevity characters through transplantation of bone marrow mononuclear cells (BMMNC) or hematopoietic stem cells (HSC)/hematopoietic stem and progenitor cells (HSPC) consisting of genetically engineered EKLF gene encoding the hematopoietic transcription factor EKLF. Secondly, the present invention demonstrates expression of EKLF in the long-term hematopoietic stem cells (LT-HSC), and thus EKLF as a target of regulation of hematopoiesis.

公开(公告)号：AU2015312098B2

公开(公告)日：2018-08-02

申请号：AU2015312098

申请日：2015-09-01

Applicant: ACADEMIA SINICA

Inventor： SHEN CHE-KUN JAMES ,  SHYU YU-CHIAU

IPC: A01N63/00 ,  C12N5/00 ,  C12N15/00

Abstract: The present invention includes a genetically-modified non-human animal model of longevity and increased health span, which is associated with reduced tumorigenesis and tumor metastasis, as well as related methods for increasing longevity and health span, reducing tumorigenesis and tumor metastasis, and identifying active agents that confer increased longevity or health span, or reduced tumorigenesis or tumor metastasis

公开(公告)号：CA2959522A1

公开(公告)日：2016-03-10

申请号：CA2959522

申请日：2015-09-01

Applicant: ACADEMIA SINICA

Inventor： SHEN CHE-KUN JAMES ,  SHYU YU-CHIAU

IPC: A01N63/00 ,  C12N5/00 ,  C12N15/00

Abstract: The present invention includes a genetically-modified non-human animal model of longevity and increased health span, which is associated with reduced tumorigenesis and tumor metastasis, as well as related methods for increasing longevity and health span, reducing tumorigenesis and tumor metastasis, and identifying active agents that confer increased longevity or health span, or reduced tumorigenesis or tumor metastasis

公开(公告)号：AU2017326234A1

公开(公告)日：2019-04-11

申请号：AU2017326234

申请日：2017-09-13

Applicant: ACADEMIA SINICA ,  HUNG CHUN HAO ,  SHEN CHE KUN JAMES ,  SHYU YU CHIAU

Inventor： SHEN CHE-KUN JAMES ,  SHYU YU-CHIAU ,  HUNG CHUN-HAO

IPC: C07K14/47 ,  A61K38/16 ,  C12N5/095

Abstract: The invention found that first, the feasibility of transfer of tumor resistance and other healthy longevity characters through transplantation of bone marrow mononuclear cells (BMMNC) or hematopoietic stem cells (HSC)/hematopoietic stem and progenitor cells (HSPC) consisting of genetically engineered EKLF gene encoding the hematopoietic transcription factor EKLF. Secondly, the present invention demonstrates expression of EKLF in the long-term hematopoietic stem cells (LT-HSC), and thus EKLF as a target of regulation of hematopoiesis.

公开(公告)号：AU2018211345A1

公开(公告)日：2018-08-23

申请号：AU2018211345

申请日：2018-08-03

Applicant: ACADEMIA SINICA

Inventor： SHYU YU-CHIAU ,  SHEN CHE-KUN JAMES

IPC: A01N63/00 ,  C12N5/00 ,  C12N15/00

Abstract: Abstract The present invention includes a genetically-modified non-human animal model of longevity and increased health span, which is associated with 5 reduced tumorigenesis and tumor metastasis, as well as related methods for increasing longevity and health span, reducing tumorigenesis and tumor metastasis, and identifying active agents that confer increased longevity or health span, or reduced tumorigenesis or tumor metastasis.