公开(公告)号：CA3036690C

公开(公告)日：2022-08-09

申请号：CA3036690

申请日：2017-09-13

Applicant: ACADEMIA SINICA ,  SHEN CHE KUN JAMES ,  SHYU YU CHIAU ,  HUNG CHUN HAO

Inventor： SHEN CHE-KUN JAMES ,  SHYU YU-CHIAU ,  HUNG CHUN-HAO

IPC: A61K38/16 ,  C07K14/47 ,  C12N5/095

Abstract: The invention found that first, the feasibility of transfer of tumor resistance and other healthy longevity characters through transplantation of bone marrow mononuclear cells (BMMNC) or hematopoietic stem cells (HSC)/hematopoietic stem and progenitor cells (HSPC) consisting of genetically engineered EKLF gene encoding the hematopoietic transcription factor EKLF. Secondly, the present invention demonstrates expression of EKLF in the long-term hematopoietic stem cells (LT-HSC), and thus EKLF as a target of regulation of hematopoiesis.

公开(公告)号：AU2017326234B2

公开(公告)日：2020-05-14

申请号：AU2017326234

申请日：2017-09-13

Applicant: ACADEMIA SINICA

Inventor： SHEN CHE-KUN JAMES ,  SHYU YU-CHIAU ,  HUNG CHUN-HAO

IPC: C07K14/47 ,  A61K38/16 ,  C12N5/095

Abstract: The invention found that first, the feasibility of transfer of tumor resistance and other healthy longevity characters through transplantation of bone marrow mononuclear cells (BMMNC) or hematopoietic stem cells (HSC)/hematopoietic stem and progenitor cells (HSPC) consisting of genetically engineered EKLF gene encoding the hematopoietic transcription factor EKLF. Secondly, the present invention demonstrates expression of EKLF in the long-term hematopoietic stem cells (LT-HSC), and thus EKLF as a target of regulation of hematopoiesis.

公开(公告)号：AU2017326234A1

公开(公告)日：2019-04-11

申请号：AU2017326234

申请日：2017-09-13

Applicant: ACADEMIA SINICA ,  HUNG CHUN HAO ,  SHEN CHE KUN JAMES ,  SHYU YU CHIAU

Inventor： SHEN CHE-KUN JAMES ,  SHYU YU-CHIAU ,  HUNG CHUN-HAO

IPC: C07K14/47 ,  A61K38/16 ,  C12N5/095

Abstract: The invention found that first, the feasibility of transfer of tumor resistance and other healthy longevity characters through transplantation of bone marrow mononuclear cells (BMMNC) or hematopoietic stem cells (HSC)/hematopoietic stem and progenitor cells (HSPC) consisting of genetically engineered EKLF gene encoding the hematopoietic transcription factor EKLF. Secondly, the present invention demonstrates expression of EKLF in the long-term hematopoietic stem cells (LT-HSC), and thus EKLF as a target of regulation of hematopoiesis.