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    Globo h and related anti-cancer vaccines with novel glycolipid adjuvants
    1.
    发明专利
    Globo h and related anti-cancer vaccines with novel glycolipid adjuvants 有权
    GLOBO H和相关的抗癌药物与新型甘露醇辅剂

    公开(公告)号：JP2014144958A

    公开(公告)日：2014-08-14

    申请号：JP2014035431

    申请日：2014-02-26

    Applicant: Academia Sinica ,  アカデミア シニカAcademia Sinica

    Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  YU ALICE ,  YU JOHN

    IPC: A61K39/00 ,  A61K39/385 ,  A61K39/39 ,  A61P35/00

    CPC classification number: A61K39/0011 ,  A61K2039/55511 ,  A61K2039/6037 ,  A61K2039/6081 ,  A61K2039/627 ,  C12N15/1137 ,  C12N2310/14

    Abstract: PROBLEM TO BE SOLVED: To provide: an immunogenic composition capable of high levels of immune responses immune-targeting glycolipid antigen Globo H, which is a tumor associated sugar chain; a cancer vaccine; and a method of treating cancer.SOLUTION: The invention relates to an immunogenic composition comprising: (a) a sugar chain such as Globo H or an immunogenic fragment thereof conjugated with a carrier protein comprising diphtheria toxin cross-reacting material 197 (DT-CRM 197) through a linker such as p-nitrophenol; and (b) an adjuvant with the following structure comprising a glycolipid capable of binding CD1d on a dendritic cell such as an α-galactosyl ceramide derivative.

    Abstract translation: 要解决的问题：提供：能够高水平免疫应答的免疫原性组合物免疫靶向糖脂抗原Globo H，其是肿瘤相关糖链; 癌症疫苗; 和一种治疗癌症的方法。解决方案：本发明涉及免疫原性组合物，其包含：（a）糖链，例如Globo H或其与包含白喉毒素交叉反应材料197（DT-CRM）的载体蛋白缀合的免疫原性片段 197）通过接头如对硝基苯酚; 和（b）具有以下结构的佐剂，其包含能够结合树突状细胞如α-半乳糖基神经酰胺衍生物上的CD1d的糖脂。

    GLYCAN ARRAYS ON PTFE-LIKE ALUMINUM COATED GLASS SLIDES AND RELATED METHODS
    2.
    发明申请
    GLYCAN ARRAYS ON PTFE-LIKE ALUMINUM COATED GLASS SLIDES AND RELATED METHODS 审中-公开
    类聚四氟乙烯涂层玻璃载玻片上的甘氨酸阵列及相关方法

    公开(公告)号：WO2010009271A3

    公开(公告)日：2010-04-22

    申请号：PCT/US2009050754

    申请日：2009-07-15

    Applicant: ACADEMIA SINICA ,  WONG CHI-HUEY ,  WU CHUNG-YI ,  TSENG SUSAN Y

    Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  TSENG SUSAN Y

    IPC: G01N33/50 ,  G01N33/66 ,  G01N33/68

    CPC classification number: G01N33/553 ,  C40B40/12 ,  C40B50/14 ,  G01N33/582 ,  G01N2333/942 ,  G01N2400/10 ,  H01J49/40

    Abstract: Aluminum coated glass slides provide a novel glycan array platform. Specifically, aluminum coated glass slides increase sensitivity of fluorescent based assay methods. Additionally, aluminum coated glass slides allows for mass spectroscopic analysis of carbohydrates and provide a platform for examining activity of cellulases. The unique properties of ACG slides include: 1) the metal oxide layer on the surface can be activated for grafting organic compounds such as modified oligosaccharides; 2) the surface remains electrically conductive, and the grafted oligosaccharides can be simultaneously characterized by mass spectrometry and carbohydrate-binding assay; and 3) the slides are more sensitive than transparent glass slides in binding analysis.

    Abstract translation: 镀铝玻璃载玻片提供了一种新型聚糖阵列平台。 具体而言，镀铝玻璃载玻片增加了基于荧光的测定方法的灵敏度。 此外，镀铝玻璃载玻片允许对碳水化合物进行质谱分析，并为检查纤维素酶的活性提供平台。 ACG玻片的独特性能包括：1）表面的金属氧化物层可以被活化以接枝有机化合物，如修饰的低聚糖; 2）表面保持导电性，并且接枝的低聚糖可以通过质谱和碳水化合物结合测定同时表征; 和3）在结合分析中，载玻片比透明载玻片更敏感。

    ANTIBODY-MEDIATED ANTI-TUMOR ACTIVITY INDUCED BY REISHI MUSHROOM POLYSACCHARIDES
    3.
    发明申请
    ANTIBODY-MEDIATED ANTI-TUMOR ACTIVITY INDUCED BY REISHI MUSHROOM POLYSACCHARIDES 审中-公开
    由REISHI MUSHROOM POLYSACCHARIDES诱导的抗体介导的抗肿瘤活性

    公开(公告)号：WO2015026484A9

    公开(公告)日：2015-04-16

    申请号：PCT/US2014048325

    申请日：2014-07-26

    Applicant: ACADEMIA SINICA ,  WONG CHI-HUEY ,  WU CHUNG-YI ,  HSU HSIEN-YEH ,  LIAO SHIH-FEN ,  LIANG CHI-HUI

    Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  HSU HSIEN-YEH ,  LIAO SHIH-FEN ,  LIANG CHI-HUI

    IPC: A61K31/715 ,  A61K31/736 ,  A61K36/074

    CPC classification number: A61K39/0002 ,  A61K36/074 ,  A61K39/0011 ,  A61K2039/55572 ,  A61K2039/575

    Abstract: Immunogenic compositions, cancer vaccines and methods for treating cancer comprising FMS, the fucose-enriched polysaccharide fraction from Reishi F3, are provided. Compositions comprise fucose-enriched Reishi polysaccharide fraction (FMS) MW = ~35kDa, wherein the FMS is isolated by size-exclusion chromatography from Reishi F3, and the FMS comprises polysaccharides having primarily a backbone selected from 1,4-mannan and 1,6-a-galactan, wherein the backbone is linked to a terminal fucose-containing side-chain. Immunogenic compositions comprising glycolipid adjuvants are provided. Antibodies generated by immunogenic compositions disclosed herein bind cancer cells comprising antigens Globo H, Globo H, Gb3, Gb4, Gb5 (SSEA-3) and SSEA-4 on the cell surface.

    Abstract translation: 提供免疫原性组合物，癌症疫苗和治疗癌症的方法，其包括FMS，来自Reishi F3的岩藻糖富集的多糖部分。 组合物包含岩藻糖富集的赖斯多糖级分（FMS）MW =〜35kDa，其中通过来自Reishi F3的大小排阻色谱分离FMS，并且FMS包含主要选自1,4-甘露聚糖和1,6 α-半乳聚糖，其中所述主链与含末端岩藻糖的侧链连接。 提供包含糖脂佐剂的免疫原性组合物。 由本文公开的免疫原性组合物产生的抗体结合细胞表面上包含抗原Globo H，Globo H，Gb 3，Gb 4，Gb 5（SSEA-3）和SSEA-4的癌细胞。

    Large scale enzymatic synthesis of oligosaccharides
    8.
    发明专利
    Large scale enzymatic synthesis of oligosaccharides 未知

    公开(公告)号：AU2019203313A1

    公开(公告)日：2019-05-30

    申请号：AU2019203313

    申请日：2019-05-10

    Applicant: ACADEMIA SINICA

    Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  TSAI TSUNG-I

    IPC: C12P19/04 ,  C12N9/10

    Abstract: Abstract A novel UDP-Gal regeneration process and its combined use with a galactosyltransferease to add galactose to a suitable acceptor substrate. Also described herein are synthetic methods for generating Globo-series oligosaccharides in large scale, wherein the methods may involve the combination of a glycosyltransferase reaction and a nucleotide sugar regeneration process.

    Large scale enzymatic synthesis of oligosaccharides
    10.
    发明专利
    Large scale enzymatic synthesis of oligosaccharides 未知

    公开(公告)号：AU2018200094A1

    公开(公告)日：2018-01-25

    申请号：AU2018200094

    申请日：2018-01-05

    Applicant: ACADEMIA SINICA

    Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  TSAI TSUNG-I

    IPC: C12P19/04 ,  C12N9/10

    Abstract: Abstract A novel UDP-Gal regeneration process and its combined use with a galactosyltransferease to add galactose to a suitable acceptor substrate. Also described herein are synthetic methods for generating Globo-series oligosaccharides in large scale, wherein the methods may involve the combination of a glycosyltransferase reaction and a nucleotide sugar regeneration process.

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