公开(公告)号：EP1987846A4

公开(公告)日：2012-11-21

申请号：EP07714571

申请日：2007-02-20

Applicant: ADEKA CORP

Inventor： SAKUMA SHINJI ,  YAMASHITA SHINJI ,  HIWATARI KEN-ICHIRO ,  SHOJI YOSHIKAZU

IPC: A61K49/00

CPC classification number: A61K49/0039 ,  A61K49/0002 ,  A61K49/0043 ,  A61K49/0052 ,  A61K49/0056 ,  A61K49/0093

Abstract: A diagnostic marker is composed of particles that have a diameter of from 1 nm to 100 µm, the particles possessing on their surfaces a site that has a high specific bonding ability to a specific antigen residing on the mucosa of digestive cancers and a site that has a low bonding ability to the mucosa of digestive organs, and further incorporating an identification material.

公开(公告)号：JP2011229495A

公开(公告)日：2011-11-17

申请号：JP2010105063

申请日：2010-04-30

Applicant: Adeka Corp ,  Nipro Patch Co Ltd ,  ニプロパッチ株式会社 ,  株式会社Adeka

Inventor： SAKUMA NOBUYUKI ,  YAMASHITA SHINJI ,  HIWATARI KENICHIRO ,  TACHIKAWA HIROYUKI ,  NAKAJIMA NORIKO ,  SHINKAI NORIHIRO

IPC: C12N5/00 ,  C07K14/47

Abstract: PROBLEM TO BE SOLVED: To provide a method for introducing a water-soluble high molecular weight substance such as nucleic acid and protein to cells through a simple process with high efficiency, and an introductory agent.SOLUTION: The method for introducing a water-soluble high molecular weight substance to cells includes a process of bringing an aqueous solution or aqueous dispersion containing grafted type polymer having a membrane-permeable peptide group on a branched chain and water-soluble high molecular weight substance (except the grafted polymer having the membrane-permeable peptide group on a side chain) into contact with cells.

Abstract translation: 要解决的问题：提供通过简单的方法高效率地向细胞中引入诸如核酸和蛋白质的水溶性高分子量物质的方法和介绍剂。 解决方案：向细胞中引入水溶性高分子量物质的方法包括使含有透膜性肽基的接枝型聚合物的水溶液或水分散体在支链上并且具有水溶性高的方法 分子量物质（侧链上具有膜可渗透肽基团的接枝聚合物除外）与细胞接触。 版权所有（C）2012，JPO＆INPIT

公开(公告)号：JP2010100781A

公开(公告)日：2010-05-06

申请号：JP2008275729

申请日：2008-10-27

Applicant: Adeka Corp ,  Josho Gakuen ,  Nipro Patch Co Ltd ,  ニプロパッチ株式会社 ,  学校法人常翔学園 ,  株式会社Adeka

Inventor： SAKUMA NOBUYUKI ,  YAMASHITA SHINJI ,  HIWATARI KENICHIRO ,  TACHIKAWA HIROYUKI ,  NAKAJIMA NORIKO ,  SHINKAI NORIHIRO

IPC: C08L101/06 ,  A61K31/137 ,  A61K38/26 ,  A61K38/28 ,  A61K47/42 ,  C08F8/30

Abstract: PROBLEM TO BE SOLVED: To provide a polymer with which absorption of a drug is improved and a stimulus imparted to a living body in drug administration is reduced, and to provide a transepithelial absorption accelerator, and formulation for medicine. SOLUTION: The polymer has a membrane permeable peptide in the side chain. At least one amino acid constituting the membrane permeable peptide is preferably a basic amino acid, Furthermore, the polymer may exist singly by itself, or may have a crosslinked structure via covalent bonding or via non-covalent bonding type interaction. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供改善药物吸收性的聚合物，并且减少给药中赋予生物体的刺激，并提供上皮上吸收促进剂和药物制剂。 解决方案：聚合物在侧链中具有膜可渗透肽。 构成膜可渗透肽的至少一个氨基酸优选为碱性氨基酸。此外，聚合物可以单独单独存在，或者可以通过共价键或通过非共价键键合相互作用而具有交联结构。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：JP2009053071A

公开(公告)日：2009-03-12

申请号：JP2007220633

申请日：2007-08-28

Applicant: Adeka Corp ,  株式会社Adeka

Inventor： SAKUMA NOBUYUKI ,  YAMASHITA SHINJI ,  HIWATARI KENICHIRO ,  SHOJI YOSHIKAZU

IPC: G01N33/543 ,  C08F299/00 ,  G01N33/545

Abstract: PROBLEM TO BE SOLVED: To provide a particulate for use in the inspection of flocculation low in the non-specific bondabilities with an antigen or an antibody and capable of greatly improving inspection sensitivity, and to provide its manufacturing method and a flocculation inspecting reagent using them.
SOLUTION: The particulate for use in the inspection of flocculation has a region low in the bonding properties to the specific antigen or the specific antibody on its surface and has a particle size of 1 nm-100 μm. The region contains a structure represented by the following formula 1 and/or a structure represented by the following formula 2.
COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：提供用于检测与抗原或抗体的非特异性结合性低的絮凝物并能够大大提高检查灵敏度的颗粒，并提供其制造方法和絮凝检查 试剂使用它们。 解决方案：用于检查絮凝的颗粒具有与特定抗原或其表面上的特异性抗体的粘合性能低的区域，并且具有1nm-100μm的粒径。 该区域包含由下式1表示的结构和/或由下式2表示的结构。版权所有（C）2009，JPO＆INPIT