公开(公告)号：CA2977462A1

公开(公告)日：2016-09-01

申请号：CA2977462

申请日：2016-02-19

Applicant: ADEKA CORP

Inventor： NEGISHI JUN ,  HIWATARI KEN-ICHIRO ,  OCHIAI KYOHEI

IPC: A61L27/00 ,  A61K35/12 ,  A61P43/00

Abstract: The present invention addresses the problem of providing a decellularized tissue having excellent cell adhesion properties. Provided is a decellularized tissue prepared by decellularizing a biological tissue, said decellularized tissue being characterized in that the ratio of endothermic energy amount, in terms of dry mass, of the decellularized tissue to the biological tissue before the decellularization is 0.70 or greater when measured by differential scanning calorimetry. The ratio by mass of DNA amount, in terms of dry mass, of the decellularized tissue to the biological tissue before the decellularization may be 0.300 or smaller.

公开(公告)号：HK1222137A1

公开(公告)日：2017-06-23

申请号：HK16110377

申请日：2016-09-01

Applicant: THE CHEMO-SERO-THERAPEUTIC RES INST ,  NAT UNIV CORP TOKYO MEDICAL AND ,  UNIV SAPPORO MEDICAL ,  ADEKA CORP

Inventor： MATSUDA JUNICHI ,  MIYABASHIRA SUMIKA ,  HARANO SATOMI ,  KISHIDA AKIO ,  KIMURA TSUYOSHI ,  NEGISHI JUN ,  HIGAMI TETSUYA ,  FUNAMOTO SEIICHI ,  HIWATARI KEN-ICHIRO ,  TASAKI AKIKO

IPC: A61L20060101 ,  A61K20060101 ,  A61P20060101

公开(公告)号：CA2987723A1

公开(公告)日：2016-12-08

申请号：CA2987723

申请日：2016-05-31

Applicant: ADEKA CORP

Inventor： HIWATARI KEN-ICHIRO ,  YAMAGUCHI YU ,  KIMURA TAKUYA ,  TASAKI AKIKO

IPC: A61F2/06 ,  A61L27/00

Abstract: The purpose of the present invention is to provide a sheet derived from a biological tissue, which can be used for the production of a tubular structure that can be used in an artificial blood vessel and has excellent pressure resistance and handling properties. For the purpose of achieving the purpose, the present invention provides: a sheet of a biological tissue, in which the edge part of at least one side has a tapered shape that becomes thin in the thickness direction toward the end of the edge part; a tubular structure produced from the sheet; and an artificial blood vessel comprising the tubular structure.

公开(公告)号：CA2911592C

公开(公告)日：2021-10-26

申请号：CA2911592

申请日：2014-05-02

Applicant: THE CHEMO SERO THERAPEUTIC RES INSTITUTE ,  UNIV NAT CORP TOKYO MEDICAL & DENTAL ,  UNIV SAPPORO MEDICAL ,  ADEKA CORP

Inventor： MATSUDA JUNICHI ,  MIYABASHIRA SUMIKA ,  HARANO SATOMI ,  KISHIDA AKIO ,  KIMURA TSUYOSHI ,  NEGISHI JUN ,  HIGAMI TETSUYA ,  FUNAMOTO SEIICHI ,  HIWATARI KEN-ICHIRO ,  TASAKI AKIKO

IPC: A61L27/00 ,  A61K9/06 ,  A61K35/12 ,  A61K35/28 ,  A61K35/30 ,  A61K35/34 ,  A61K35/407 ,  A61K35/42 ,  A61K38/43 ,  A61K38/48 ,  A61P9/10

Abstract: A hybrid gel comprising a particulate decellularized tissue obtained by pulverizing animal-derived biological tissues that are decellularized (decellularized biological tissues), fibrinogen and thrombin; a cell culture material comprising the hybrid gel; a method for preparing the hybrid gel; and a kit comprising a particulate decellularized tissue and a biological tissue adhesive are provided. The hybrid gel may exert the effect to promote differentiation and gain of function of stem cells and the therapeutic effect to a variety of diseases.

公开(公告)号：HK1247077A1

公开(公告)日：2018-09-21

申请号：HK18106721

申请日：2018-05-24

Applicant: ADEKA CORP

Inventor： HIWATARI KEN-ICHIRO ,  YAMAGUCHI YU ,  KIMURA TAKUYA ,  TASAKI AKIKO

IPC: A61F20060101 ,  A61L20060101

公开(公告)号：CA2911592A1

公开(公告)日：2014-11-13

申请号：CA2911592

申请日：2014-05-02

Applicant: CHEMO SERO THERAPEUT RES INST ,  NAT UNIV CORP TOKYO MED & DENT ,  UNIV SAPPORO MEDICAL ,  ADEKA CORP

Inventor： MATSUDA JUNICHI ,  MIYABASHIRA SUMIKA ,  HARANO SATOMI ,  KISHIDA AKIO ,  KIMURA TSUYOSHI ,  NEGISHI JUN ,  HIGAMI TETSUYA ,  FUNAMOTO SEIICHI ,  HIWATARI KEN-ICHIRO ,  TASAKI AKIKO

IPC: A61L27/00 ,  A61K9/06 ,  A61K35/12 ,  A61K35/28 ,  A61K35/30 ,  A61K35/34 ,  A61K35/407 ,  A61K35/42 ,  A61K38/43 ,  A61K38/48 ,  A61P9/10

Abstract: Provided are: a hybrid gel that contains a particulate decellularized tissue (a product prepared by grinding a decellularized biological tissue that is obtained by decellularizing a biological tissue derived from an animal), fibrinogen and thrombin; a cell culture base material containing the hybrid gel; a method for preparing the hybrid gel; and a kit containing a particulate decellularized tissue and an adhesive for biological tissues. The hybrid gel according to the present invention has an effect of promoting the differentiation and function acquisition of stem cells and therapeutic effects on various diseases.

公开(公告)号：CA2978401C

公开(公告)日：2022-04-12

申请号：CA2978401

申请日：2016-03-07

Applicant: THE CHEMO SERO THERAPEUTIC RES INSTITUTE ,  ADEKA CORP ,  UNIV NAT CORP TOKYO MEDICAL & DENTAL ,  UNIV SAPPORO MEDICAL

Inventor： UCHIDA TAKANORI ,  SAGA HIDEKI ,  TOKOROZAKI SHOKO ,  HIWATARI KEN-ICHIRO ,  OBARA HARUKI ,  KISHIDA AKIO ,  KIMURA TSUYOSHI ,  NEGISHI JUN ,  HIGAMI TETSUYA ,  FUNAMOTO SEIICHI

IPC: A61L31/00

Abstract: An anti-adhesion material comprising a decellularized tissue and a biocompatible polymer or fibrin glue; a method for producing an anti-adhesion material, comprising applying a biocompatible polymer or fibrin glue to a decellularized tissue; an anti-adhesion material kit comprising a decellularized tissue and a biocompatible polymer or fibrin glue; an artificial biological membrane comprising a decellularized tissue and a biocompatible polymer or fibrin glue; a method for producing an artificial biological membrane, comprising applying a biocompatible polymer or fibrin glue to a decellularized tissue; and an artificial biological membrane kit comprising a decellularized tissue and a biocompatible polymer or fibrin glue.

公开(公告)号：CA2978401A1

公开(公告)日：2016-09-15

申请号：CA2978401

申请日：2016-03-07

Applicant: THE CHEMO-SERO-THERAPEUTIC RES INST ,  ADEKA CORP ,  NAT UNIV CORP TOKYO MEDICAL & DENTAL UNIV ,  UNIV SAPPORO MEDICAL

Inventor： SAGA HIDEKI ,  UCHIDA TAKANORI ,  TOKOROZAKI SHOKO ,  HIWATARI KEN-ICHIRO ,  OBARA HARUKI ,  KISHIDA AKIO ,  KIMURA TSUYOSHI ,  NEGISHI JUN ,  HIGAMI TETSUYA ,  FUNAMOTO SEIICHI

IPC: A61L31/00

Abstract: An anti-adhesion material comprising a decellularized tissue and a biocompatible polymer or fibrin glue; a method for producing an anti-adhesion material, comprising applying a biocompatible polymer or fibrin glue to a decellularized tissue; an anti-adhesion material kit comprising a decellularized tissue and a biocompatible polymer or fibrin glue; an artificial biological membrane comprising a decellularized tissue and a biocompatible polymer or fibrin glue; a method for producing an artificial biological membrane, comprising applying a biocompatible polymer or fibrin glue to a decellularized tissue; and an artificial biological membrane kit comprising a decellularized tissue and a biocompatible polymer or fibrin glue.

公开(公告)号：EP1987846A4

公开(公告)日：2012-11-21

申请号：EP07714571

申请日：2007-02-20

Applicant: ADEKA CORP

Inventor： SAKUMA SHINJI ,  YAMASHITA SHINJI ,  HIWATARI KEN-ICHIRO ,  SHOJI YOSHIKAZU

IPC: A61K49/00

CPC classification number: A61K49/0039 ,  A61K49/0002 ,  A61K49/0043 ,  A61K49/0052 ,  A61K49/0056 ,  A61K49/0093

Abstract: A diagnostic marker is composed of particles that have a diameter of from 1 nm to 100 µm, the particles possessing on their surfaces a site that has a high specific bonding ability to a specific antigen residing on the mucosa of digestive cancers and a site that has a low bonding ability to the mucosa of digestive organs, and further incorporating an identification material.

公开(公告)号：EP3263582A4

公开(公告)日：2018-07-18

申请号：EP16755452

申请日：2016-02-23

Applicant: JOSHO GAKUEN EDUCATIONAL FOUND ,  ADEKA CORP

Inventor： SAKUMA SHINJI ,  MOHRI KOHTA ,  HIWATARI KEN-ICHIRO ,  OCHIAI KYOHEI

IPC: C07K2/00 ,  C08F8/30 ,  C08F220/06 ,  C08F220/56 ,  C08F226/02 ,  C08G81/00

CPC classification number: C08F8/30 ,  A61K47/32 ,  C07K2/00 ,  C07K5/06026 ,  C08F220/06 ,  C08F220/56 ,  C08F226/02 ,  C08G81/00 ,  C08F2220/603

Abstract: A polymer compound of the present invention has a group represented by Formula (1) or Formula (2) in a side chain. (In Formula (1), X 1 represents a neutral amino acid residue or an É -aminoalkanoic acid residue, X 2 represents a membrane-permeable peptide residue, X 3 represents a hydroxyl group, an amino group, an alkoxyl group having 1 to 4 carbon atoms, or a benzyloxy group, and a represents a number of from 1 to 50.) (In Formula (2), X 4 represents a neutral amino acid residue or an É -aminoalkanoic acid residue, X 5 represents a membrane-permeable peptide residue, X 6 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a benzyl group, an acyl group having 1 to 6 carbon atoms, an arylsulfonyl group, or a carboxyl group, and b represents a number of from 1 to 50.)