公开(公告)号：US20180078679A1

公开(公告)日：2018-03-22

申请号：US15556776

申请日：2016-03-07

Applicant: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE ,  ADEKA CORPORATION ,  NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY ,  SAPPORO MEDICAL UNIVERSITY

Inventor： Hideki SAGA ,  Takanori UCHIDA ,  Shoko TOKOROZAKI ,  Ken-ichiro HIWATARI ,  Haruki OBARA ,  Akio KISHIDA ,  Tsuyoshi KIMURA ,  Jun NEGISHI ,  Tetsuya HIGAMI ,  Seiichi FUNAMOTO

IPC: A61L31/04

CPC classification number: A61L31/046 ,  A61L24/106 ,  A61L31/005 ,  A61L31/10 ,  A61L2300/424

Abstract: An anti-adhesion material comprising decellularized tissues and a biocompatible polymer or fibrin glue; a method for preparing an anti-adhesion material comprising complexing a biocompatible polymer or fibrin glue to decellularized tissues; an anti-adhesion material kit comprising decellularized tissues and a biocompatible polymer or fibrin glue; a substitute biomembrane comprising decellularized tissues and a biocompatible polymer or fibrin glue; a method for preparing a substitute biomembrane comprising complexing a biocompatible polymer or fibrin glue to decellularized tissues; and a substitute biomembrane kit comprising decellularized tissues and a biocompatible polymer or fibrin glue.

公开(公告)号：US20180028722A1

公开(公告)日：2018-02-01

申请号：US15552669

申请日：2016-02-19

Applicant: ADEKA CORPORATION

Inventor： Jun NEGISHI ,  Ken-ichiro HIWATARI ,  Kyohei OCHIAI

IPC: A61L27/36

CPC classification number: A61L27/3691 ,  A61K35/12 ,  A61L27/3683 ,  A61L27/3687 ,  A61L2400/18 ,  A61L2430/40

Abstract: The present invention addresses the problem of providing a decellularized tissue having excellent cell adhesion properties. Provided is a decellularized tissue prepared by decellularizing a biological tissue, said decellularized tissue being characterized in that the ratio of endothermic energy amount, in terms of dry mass, of the decellularized tissue to the biological tissue before the decellularization is 0.70 or greater when measured by differential scanning calorimetry. The ratio by mass of DNA amount, in terms of dry mass, of the decellularized tissue to the biological tissue before the decellularization may be 0.300 or smaller.

公开(公告)号：US20180016366A1

公开(公告)日：2018-01-18

申请号：US15547840

申请日：2016-02-23

Applicant: JOSHO GAKUEN EDUCATIONAL FOUNDATION ,  ADEKA CORPORATION

Inventor： Shinji SAKUMA ,  Kohta MOHRI ,  Ken-ichiro HIWATARI ,  Kyohei OCHIAI

IPC: C08F8/30 ,  C07K5/062 ,  A61K47/32

CPC classification number: C08F8/30 ,  A61K47/32 ,  C07K2/00 ,  C07K5/06026 ,  C08F220/06 ,  C08F220/56 ,  C08F226/02 ,  C08G81/00 ,  C08F2220/603

Abstract: A polymer compound has a group represented by Formula (1) or Formula (2) in a side chain. (In Formula (1), X1 represents a neutral amino acid residue or an ω-aminoalkanoic acid residue, X2 represents a membrane-permeable peptide residue, X3 represents a hydroxyl group, an amino group, an alkoxyl group having 1 to 4 carbon atoms, or a benzyloxy group, and a represents a number of from 1 to 50.) (In Formula (2), X4 represents a neutral amino acid residue or an ω-aminoalkanoic acid residue, X5 represents a membrane-permeable peptide residue, X6 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a benzyl group, an acyl group having 1 to 6 carbon atoms, an arylsulfonyl group, or a carboxyl group, and b represents a number of from 1 to 50.)

公开(公告)号：US20180044381A1

公开(公告)日：2018-02-15

申请号：US15547595

申请日：2016-02-23

Applicant: JOSHO GAKUEN EDUCATIONAL FOUNDATION ,  ADEKA CORPORATION

Inventor： Shinji SAKUMA ,  Kohta MOHRI ,  Ken-ichiro HIWATARI ,  Kyohei OCHIAI

IPC: C07K9/00 ,  A61K47/36 ,  A61K47/42

Abstract: A polysaccharide derivative has a partial structure represented by Formula (1) below. It is preferable that at least one of the amino acids that constitute X2 in Formula (1) below is a basic amino acid. (In the formula, X1 represents a residue obtained by removing the terminal amino group and the terminal carboxyl group from a neutral amino acid or an ω-aminoalkanoic acid, X2 represents a residue obtained by removing the terminal amino group and the terminal carboxyl group from a membrane-permeable peptide, X3 represents a hydroxyl group, an amino group, an alkoxyl group having 1 to 4 carbon atoms, or a benzyloxy group, a represents a number of 0 or 1, and b represents a number of from 0 to 50.)

公开(公告)号：US20160058910A1

公开(公告)日：2016-03-03

申请号：US14783232

申请日：2014-05-02

Applicant: NATIIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY ,  ADEKA CORPORATION

Inventor： Akio KISHIDA ,  Tsuyoshi KIMURA ,  Jun NEGISHI ,  Ken-ichiro HIWATARI ,  Akiko TASAKI

IPC: A61L27/36 ,  A61L27/54 ,  A61L27/58 ,  C12N5/00

Abstract: A particulate decellularized tissue is provided which shows sufficiently effective tissue regeneration and does not show cytotoxicity when used as material for cell culture. In accordance with the method for preparing a particulate decellularized tissue comprising a step of applying a high hydrostatic pressure to animal-derived tissues in a medium, a particulate decellularized tissue is obtained which does not show cytotoxicity but shows the effect of cellular attraction and the effect of induction of cellular differentiation and shows a high effect of tissue regeneration.

Abstract translation: 提供了一种颗粒脱细胞组织，其显示出足够有效的组织再生，并且当用作细胞培养的材料时不显示细胞毒性。 根据制备颗粒脱细胞组织的方法，包括将高静水压力施加到培养基中的动物衍生组织的步骤，获得不显示细胞毒性但显示细胞吸引作用的效果的颗粒脱细胞组织 的细胞分化诱导，并显示组织再生的高效果。

公开(公告)号：US20220323647A1

公开(公告)日：2022-10-13

申请号：US17851283

申请日：2022-06-28

Applicant: ADEKA CORPORATION

Inventor： Ken-ichiro HIWATARI ,  Yu YAMAGUCHI ,  Takuya KIMURA ,  Akiko TASAKI

IPC: A61L27/36 ,  A61F2/06 ,  A61L27/50

Abstract: A sheet of biological tissue which includes on at least one side tapered edge portion thinning down in the thickness direction, towards an end thereof, a tubular structure obtained from the sheet, and an artificial blood vessel made up of the tubular structure are provided.

公开(公告)号：US20180296728A1

公开(公告)日：2018-10-18

申请号：US15576761

申请日：2016-05-31

Applicant: ADEKA CORPORATION

Inventor： Ken-ichiro HIWATARI ,  Yu YAMAGUCHI ,  Takuya KIMURA ,  Akiko TASAKI

IPC: A61L27/36 ,  A61F2/06

Abstract: A sheet of biological tissue which includes on at least one side tapered edge portion thinning down in the thickness direction, towards an end thereof, a tubular structure obtained from the sheet, and an artificial blood vessel made up of the tubular structure are provided.

公开(公告)号：US20160051731A1

公开(公告)日：2016-02-25

申请号：US14888871

申请日：2014-05-02

Applicant: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE ,  NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY ,  SAPPORO MEDICAL UNIVERSITY ,  ADEKA CORPORATION

Inventor： Junichi MATSUDA ,  Sumika MIYABASHIRA ,  Satomi HARANO ,  Akio KISHIDA ,  Tsuyoshi KIMURA ,  Jun NEGISHI ,  Tetsuya HIGAMI ,  Seiichi FUNAMOTO ,  Ken-ichiro HIWATARI ,  Akiko TASAKI

IPC: A61L27/52 ,  A61L27/22 ,  A61L27/26 ,  C12N5/00 ,  A61L27/36

CPC classification number: A61L27/52 ,  A61K35/22 ,  A61K35/30 ,  A61K35/34 ,  A61K35/407 ,  A61K35/42 ,  A61K38/363 ,  A61K38/4833 ,  A61L27/225 ,  A61L27/26 ,  A61L27/3633 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/3695 ,  A61L27/54 ,  A61L2430/00 ,  A61L2430/20 ,  A61L2430/32 ,  C12N5/0068 ,  C12N2533/50 ,  C12N2533/56 ,  C12N2533/90

Abstract: A hybrid gel comprising a particulate decellularized tissue (obtained by pulverizing animal-derived biological tissues that are decellularized (decellularized biological tissues)), fibrinogen and thrombin; a cell culture material comprising the hybrid gel; a method for preparing the hybrid gel; and a kit comprising a particulate decellularized tissue and a biological tissue adhesive are provided. The hybrid gel of the present invention exerts the effect to promote differentiation and gain of function of stem cells and the therapeutic effect to a variety of diseases.

Abstract translation: 一种混合凝胶，其包含颗粒脱细胞组织（通过粉碎去细胞化的（来自脱细胞的生物组织）的动物衍生的生物组织），纤维蛋白原和凝血酶获得; 包含所述杂交凝胶的细胞培养物质; 制备混合凝胶的方法; 并提供了包含颗粒脱细胞组织和生物组织粘合剂的试剂盒。 本发明的混合凝胶发挥促进干细胞分化和增殖功能的效果以及对各种疾病的治疗效果。