公开(公告)号：US20200222589A1

公开(公告)日：2020-07-16

申请号：US16615177

申请日：2018-05-25

Applicant: ADEKA CORPORATION

Inventor： Tetsuya HIGAMI ,  Kenichiro HIWATARI ,  Yu YAMAGUCHI ,  Haruki OBARA ,  Takuya KIMURA ,  Mitsumasa HOMMA ,  Kyohei OCHIAI ,  Keita KINOSHITA ,  Naoki MORIMOTO

IPC: A61L27/36 ,  A61L27/50

Abstract: A method of producing a decellularized transplantation material, wherein the method includes the steps of (a) harvesting a branch-bearing blood vessel from a vertebrate animal (a donor); (b) decellularizing the blood vessel; and (c) adhering, by a protein denaturation treatment, a portion where a branch has been excised to close the vessel. Also, a graft composition consisting of a biocompatible material that contains the decellularized transplantation material.

公开(公告)号：US20250108147A1

公开(公告)日：2025-04-03

申请号：US18036218

申请日：2021-11-12

Applicant: ADEKA CORPORATION

Inventor： Mitsumasa HOMMA ,  Kenichiro HIWATARI ,  Haruki OBARA ,  Takuya KIMURA ,  Keita KINOSHITA

IPC: A61L27/36 ,  A61L27/22

Abstract: The object of the present invention is to provide a decellularized tissue that has appropriate strength and exhibits good tissue regeneration.
The problem can be solved by a decellularized tissue composition comprising a decellularized tissue and a protein A with (a) molecular weight of 30,000 to 70,000 and (b) isoelectric point of pI 6.00 to 9.00

公开(公告)号：US20200254146A1

公开(公告)日：2020-08-13

申请号：US16755948

申请日：2018-10-24

Applicant: ADEKA CORPORATION

Inventor： Yu YAMAGUCHI ,  Takuya KIMURA

IPC: A61L27/50 ,  A61L27/36

Abstract: The present invention relates to a biomaterial-derived sheet-like decellularized material having a maximum value of tensile strength in four directions of 4 MPa or more and an elongation rate in the direction exhibiting the maximum tensile strength of 50% to 300%. The present invention can provide a sheet-like material capable of maintaining excellent pressure resistance when used as an artificial blood vessel or for repair of a blood vessel.

公开(公告)号：US20220323647A1

公开(公告)日：2022-10-13

申请号：US17851283

申请日：2022-06-28

Applicant: ADEKA CORPORATION

Inventor： Ken-ichiro HIWATARI ,  Yu YAMAGUCHI ,  Takuya KIMURA ,  Akiko TASAKI

IPC: A61L27/36 ,  A61F2/06 ,  A61L27/50

Abstract: A sheet of biological tissue which includes on at least one side tapered edge portion thinning down in the thickness direction, towards an end thereof, a tubular structure obtained from the sheet, and an artificial blood vessel made up of the tubular structure are provided.

公开(公告)号：US20180296728A1

公开(公告)日：2018-10-18

申请号：US15576761

申请日：2016-05-31

Applicant: ADEKA CORPORATION

Inventor： Ken-ichiro HIWATARI ,  Yu YAMAGUCHI ,  Takuya KIMURA ,  Akiko TASAKI

IPC: A61L27/36 ,  A61F2/06

Abstract: A sheet of biological tissue which includes on at least one side tapered edge portion thinning down in the thickness direction, towards an end thereof, a tubular structure obtained from the sheet, and an artificial blood vessel made up of the tubular structure are provided.