公开(公告)号：EP1839667A2

公开(公告)日：2007-10-03

申请号：EP07009031.1

申请日：1999-09-23

Applicant: An-Go-Gen Inc.

Inventor： Stewart, Duncan J.

IPC: A61K35/36

CPC classification number: A61K38/44 ,  A61K35/36 ,  A61K38/1866 ,  A61K48/00 ,  A61K48/0075 ,  C07K14/52 ,  C12Y114/13039

Abstract: Cell-based gene transfer is effected by administering transfected fibroblast cells, from dermal or other origins, containing an expressible transgene coding for an angiogenic factor or other therapeutic factor, into the pulmonary circulation of a patient, where the cells express and secrete expression products of the transgene to act locally at the site of expression, and in some cases to be conveyed by the patient's circulation to other body organs. The process is especially useful in treatment of pulmonary hypertension by means of expressed angiogenic factors.

Abstract translation: 基于细胞的基因转移通过将包含编码血管生成因子或其他治疗因子的可表达转基因的真皮或其它来源的转染的成纤维细胞投予患者的肺循环来实现，其中细胞表达和分泌表达产物 转基因在局部表达的地方采取行动，在某些情况下由病人传播给其他身体器官。 该方法特别适用于通过表达血管生成因子治疗肺动脉高压。