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    CELL-BASED GENE THERAPY FOR THE PULMONARY SYSTEM
    4.
    发明授权
    CELL-BASED GENE THERAPY FOR THE PULMONARY SYSTEM 有权
    基于细胞的基因治疗肺系统

    公开(公告)号：EP1220679B1

    公开(公告)日：2007-06-13

    申请号：EP99944205.6

    申请日：1999-09-23

    Applicant: An-Go-Gen Inc.

    Inventor： STEWART, Duncan, J.

    IPC: A61K35/36 ,  A61K48/00 ,  C12N5/10

    CPC classification number: A61K38/44 ,  A61K35/36 ,  A61K38/1866 ,  A61K48/00 ,  A61K48/0075 ,  C07K14/52 ,  C12Y114/13039

    Abstract: Cell-based gene transfer is effected by administering transfected fibroblast cells, from dermal or other origins, containing an expressible transgene coding for an angiogenic factor or other therapeutic factor, into the pulmonary circulation of a patient, where the cells express and secrete expression products of the transgene to act locally at the site of expression, and in some cases to be conveyed by the patient's circulation to other body organs. The process is especially useful in treatment of pulmonary hypertension by means of expressed angiogenic factors.

    Cell-based gene therapy for the pulmonary system
    7.
    发明公开
    Cell-based gene therapy for the pulmonary system 有权
    成纤维细胞和内皮细胞生长激素对Gentherapiefürdas Lungensystem

    公开(公告)号：EP1839667A2

    公开(公告)日：2007-10-03

    申请号：EP07009031.1

    申请日：1999-09-23

    Applicant: An-Go-Gen Inc.

    Inventor： Stewart, Duncan J.

    IPC: A61K35/36

    CPC classification number: A61K38/44 ,  A61K35/36 ,  A61K38/1866 ,  A61K48/00 ,  A61K48/0075 ,  C07K14/52 ,  C12Y114/13039

    Abstract: Cell-based gene transfer is effected by administering transfected fibroblast cells, from dermal or other origins, containing an expressible transgene coding for an angiogenic factor or other therapeutic factor, into the pulmonary circulation of a patient, where the cells express and secrete expression products of the transgene to act locally at the site of expression, and in some cases to be conveyed by the patient's circulation to other body organs. The process is especially useful in treatment of pulmonary hypertension by means of expressed angiogenic factors.

    Abstract translation: 基于细胞的基因转移通过将包含编码血管生成因子或其他治疗因子的可表达转基因的真皮或其它来源的转染的成纤维细胞投予患者的肺循环来实现，其中细胞表达和分泌表达产物 转基因在局部表达的地方采取行动，在某些情况下由病人传播给其他身体器官。 该方法特别适用于通过表达血管生成因子治疗肺动脉高压。

    CELL-BASED GENE THERAPY FOR THE PULMONARY SYSTEM
    8.
    发明公开
    CELL-BASED GENE THERAPY FOR THE PULMONARY SYSTEM 有权
    基于细胞的基因治疗肺系统

    公开(公告)号：EP1220679A1

    公开(公告)日：2002-07-10

    申请号：EP99944205.6

    申请日：1999-09-23

    Applicant: An-Go-Gen Inc.

    Inventor： STEWART, Duncan, J.

    IPC: A61K35/36 ,  A61K48/00 ,  C12N5/10

    CPC classification number: A61K38/44 ,  A61K35/36 ,  A61K38/1866 ,  A61K48/00 ,  A61K48/0075 ,  C07K14/52 ,  C12Y114/13039

    Abstract: Cell-based gene transfer is effected by administering transfected fibroblast cells, from dermal or other origins, containing an expressible transgene coding for an angiogenic factor or other therapeutic factor, into the pulmonary circulation of a patient, where the cells express and secrete expression products of the transgene to act locally at the site of expression, and in some cases to be conveyed by the patient's circulation to other body organs. The process is especially useful in treatment of pulmonary hypertension by means of expressed angiogenic factors.

    CELL-BASED GENE THERAPY
    9.
    发明专利
    CELL-BASED GENE THERAPY 未知

    公开(公告)号：CA2227425A1

    公开(公告)日：1999-09-27

    申请号：CA2227425

    申请日：1998-03-27

    Applicant: AN GO GEN INC

    Inventor： STEWART DUNCAN JOHN

    IPC: A61K35/12 ,  A61K38/18 ,  A61K38/19 ,  A61K38/44 ,  A61K48/00

    Abstract: Cell-based gene transfer is effected by administering transfected cells containing an expressible transgene into the pulmonary system of a patient, where the cells express and secrete expression products of the transgene directly into the pulmonary system. Also provided is the use of angiogenic factors in treatment of pulmonary hypertension.

    CATHETERS
    10.
    发明专利
    CATHETERS 未知

    公开(公告)号：CA2241615A1

    公开(公告)日：1998-12-26

    申请号：CA2241615

    申请日：1998-06-26

    Applicant: STEWART DUNCAN JOHN ,  LANGER ANATOLY ,  AN GO GEN INC

    Inventor： STEWART DUNCAN JOHN ,  LANGER ANATOLY

    IPC: A61B17/00 ,  A61B17/22 ,  A61M25/00 ,  A61M25/092

    Abstract: A catheter assembly especially adapted for injecting therapeutic liquids such as DNA solutions to a patient's myocardium comprises an elongated guiding catheter for insertion through a patient's artery to the vicinity of the myocardium, a reservoir for therapeutic liquid at the distal end of the guiding catheter, one or more injection needles protruding from the distal end of the guiding catheter and in fluid communication with the reservoir, the extent of needle protrusion being appropriate for penetration of but not passage through the myocardial wall, and operating means for delivering a predetermined quantity of therapeutic liquid from the reservoir through the needles.

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