公开(公告)号：WO2007071578A3

公开(公告)日：2007-11-08

申请号：PCT/EP2006069511

申请日：2006-12-11

Applicant: BASF AG ,  KESSELER MARIA ,  HAUER BERNHARD

Inventor： KESSELER MARIA ,  HAUER BERNHARD

IPC: C12N15/55 ,  C07C51/08 ,  C12N1/21 ,  C12N9/78 ,  C12P7/40

CPC classification number: C12P7/40 ,  C07C2601/10 ,  C12N9/78 ,  C12P41/006

Abstract: The present invention relates to a method for producing 5-norbornen-2-carboxylic acid from 5-norbornen-2-endo-carbonitrile and/or 5-norbornen-2-exo-carbonitrile. The invention relates more specifically to a method for producing 5-norbornen-2-carboxylic acid at a high substrate concentration. Furthermore, the invention relates to a polypeptide suitable for the enzymatic reaction of 5-norbornen-2-carbonitrile to 5-norbornen-2-carboxylic acid, particularly also at a high substrate concentration, as well as to a nucleic acid coding for the polypeptide, a composition containing 5-norbornen-2-carbonitrile to 5-norbornen-2-endo-carboxylic acid and 5-norbornen-2-exo-carboxylic acid, as well as the use of the polypeptide.

Abstract translation: 本发明涉及一种方法，用于从5-降冰片烯-2-内 - 腈和/或5-降冰片烯-2-外 - 腈制备的5-降冰片烯-2-羧酸。 特别地，本发明涉及一种方法，其中所述5-降冰片烯-2-羧酸可在高底物浓度而制备。 本发明还涉及适用于5-降冰片烯-2-甲腈的酶促转化为5-降冰片烯-2-羧酸，尤其是即使在高底物浓度的多肽，以及编码核酸的多肽，组合物，含有5-降冰片烯-2- 腈向5-降冰片烯-2-内 - 羧酸和5-降冰片烯-2-外 - 羧酸，和使用所述多肽的。

公开(公告)号：WO2007063037A2

公开(公告)日：2007-06-07

申请号：PCT/EP2006068882

申请日：2006-11-24

Applicant: BASF AG ,  HAERING DIETMAR ,  HERRERA TABOADA LIDCAY ,  HAUER BERNHARD ,  FRIEDRICH THOMAS ,  GOETHLICH ALEXANDER

Inventor： HAERING DIETMAR ,  HERRERA TABOADA LIDCAY ,  HAUER BERNHARD ,  FRIEDRICH THOMAS ,  GOETHLICH ALEXANDER

CPC classification number: C08F220/18 ,  C08F8/14 ,  C08F220/62 ,  C08F220/00

Abstract: The invention relates to a method for reesterifying or esterifying side chains in polymers. Said method comprises the following steps: a) a copolymer is produced which is obtained by polymerizing aa) at least one (meth)acrylate of general formula (I) as component A, wherein R 1 represents H or CH 3 while R 2 represents H or an alkyl radical that can be optionally substituted with functional groups such as acryl groups, ether groups, amino groups, epoxy groups, halogen groups, or sulfonic acid groups, and ab) at least one monomer of general formula (II) as component B, wherein R 3 has the same meaning as R 1 , R 4 has the same meaning as R 2 , and n = 1 to 40, and b) reesterifying or esterifying the carboxyl group containing the radical R 4 with an alcohol in the presence of an enzyme catalyzing the reesterification or esterification process. The invention also relates to said polymers and the use thereof.

Abstract translation: 本发明涉及一种用于酯化或酯交换中的聚合物侧链，其包括以下步骤：a）制备由氨基酸的聚合而得到的共聚物）的通式（I）作为组分A的至少一种（甲基）丙烯酸酯，其中R H或CH 3和R 2是H或任选被官能团取代的烷基，所述官能团如丙烯酸，醚，氨基 - ，通式（II）作为组分B，其中R ^{3 的含义与R相同 1}

公开(公告)号：WO03020942A2

公开(公告)日：2003-03-13

申请号：PCT/EP0209723

申请日：2002-08-30

Applicant: BASF AG ,  HAUER BERNHARD ,  BREUER MICHAEL ,  ROGERS PETER ,  SANDFORD VANESSA ,  ROSCHE BETTINA

Inventor： HAUER BERNHARD ,  BREUER MICHAEL ,  ROGERS PETER ,  SANDFORD VANESSA ,  ROSCHE BETTINA

IPC: C12N9/88 ,  C12P7/22 ,  C12P7/26

CPC classification number: C12P7/22 ,  C12N9/88 ,  C12P7/26

Abstract: This application relates to a new process for the production of R-phenylacetylcarbinol by an enzymatic process in a liquid two-phase system.

Abstract translation: 本申请涉及通过液相两相体系中的酶法生产R-苯乙酰基甲醇的新方法。

公开(公告)号：WO2007071599A3

公开(公告)日：2007-08-16

申请号：PCT/EP2006069626

申请日：2006-12-13

Applicant: BASF AG ,  HAUER BERNHARD ,  JANSSEN DICK B ,  MAJERIC-ELENKOV MAJA

Inventor： HAUER BERNHARD ,  JANSSEN DICK B ,  MAJERIC-ELENKOV MAJA

IPC: C12P7/02 ,  C12P7/42 ,  C12P7/62 ,  C12P13/00 ,  C12P17/02 ,  C12P41/00

CPC classification number: C12P41/002 ,  C12P7/02 ,  C12P7/42 ,  C12P7/62 ,  C12P13/00 ,  C12P13/002 ,  C12P13/004 ,  C12P13/008 ,  C12P13/02 ,  C12P17/02

Abstract: A process for the production of an optically enriched tertiary alcohol of the formula (2a) or (2b), by reacting an epoxide of the formula (1) with a nucleophilic agent Nu in the presence of halohydrin dehalogenase.

Abstract translation: 通过在卤代醇脱卤素酶的存在下使式（1）的环氧化物与亲核剂Nu反应来制备式（2a）或（2b）的光学富集的叔醇的方法。

公开(公告)号：WO2006092425A3

公开(公告)日：2007-04-19

申请号：PCT/EP2006060389

申请日：2006-03-02

Applicant: BASF AG ,  HAERING DIETMAR ,  HAUER BERNHARD ,  PFEIFFER THOMAS ,  FECHTENKOETTER ANDREAS ,  LARBIG HARALD ,  BECK ERICH

Inventor： HAERING DIETMAR ,  HAUER BERNHARD ,  PFEIFFER THOMAS ,  FECHTENKOETTER ANDREAS ,  LARBIG HARALD ,  BECK ERICH

IPC: C08F8/14 ,  B01F17/52 ,  C08F210/02 ,  C08F216/14 ,  C08F220/28 ,  C08F255/02 ,  C09D11/02 ,  C09D133/08 ,  C14C9/00 ,  D06M15/21

CPC classification number: C09D11/12 ,  C08F8/00 ,  C08F210/02 ,  C08F255/02 ,  C08L23/0869 ,  C09D7/65 ,  C08F10/00 ,  C08F220/00 ,  C08F218/04 ,  C08F2500/02 ,  C08F220/12

Abstract: The invention relates to modified polyolefin waxes carrying (meth)acrylate groups and to a method for the production and use thereof

Abstract translation: （甲基）acrylatgruppentragende聚烯烃，它们的制备方法以及它们的用途。

公开(公告)号：WO2006133900A9

公开(公告)日：2007-03-08

申请号：PCT/EP2006005668

申请日：2006-06-13

Applicant: BASF AG ,  BESELIN ANKE ,  ROSENAU FRANK ,  JAEGER KARL-ERICH ,  BREUER MICHAEL ,  HAUER BERNHARD

Inventor： BESELIN ANKE ,  ROSENAU FRANK ,  JAEGER KARL-ERICH ,  BREUER MICHAEL ,  HAUER BERNHARD

IPC: C12N9/52

CPC classification number: C12N9/52 ,  C12N9/20

Abstract: The invention relates to novel proteins, in particular, exhibiting a protease activity and promoting the production of extracellular lipases by bacteria, in particular, by Burkholderia-type bacteria, to coding nucleic acid sequences, expression constructs containing them, host modified thereby, to a method for producing proteins exhibiting a protease activity and to a lipase production method, in particular by Burkholderia-type bacteria.

Abstract translation: 本发明涉及的特别是伯克霍尔德氏菌属，含有这些表达构建体的核酸编码的序列，宿主经转化与之新的蛋白质，特别是具有蛋白酶活性，其通过细菌促进生产细胞外脂肪酶的，用于制备具有蛋白酶活性以及方法的蛋白质的用于生产脂酶的方法， 特别是通过伯克霍尔德氏菌属的细菌。

公开(公告)号：WO2005108590A3

公开(公告)日：2006-04-06

申请号：PCT/EP2005004872

申请日：2005-05-04

Applicant: BASF AG ,  STUERMER RAINER ,  KESSELER MARIA ,  HAUER BERNHARD ,  FRIEDRICH THOMAS ,  BREUER MICHAEL ,  SCHROEDER HARTWIG

Inventor： STUERMER RAINER ,  KESSELER MARIA ,  HAUER BERNHARD ,  FRIEDRICH THOMAS ,  BREUER MICHAEL ,  SCHROEDER HARTWIG

IPC: C12P7/02 ,  C07D333/16 ,  C12N9/04 ,  C12P20060101 ,  C12P13/00 ,  C12P17/00

CPC classification number: C07D333/22 ,  C07D333/16 ,  C12P17/00

Abstract: The invention relates to a method for producing the optically active alkanols of formula (I), wherein n is an integer of from 0 to 5; Cyc represents an optionally substituted, mononuclear or polynuclear, saturated or unsaturated, carbocylic or heterocyclic ring, and R

Abstract translation: 一种用于制备式（I）其中n是从0至5的整数的光学活性链烷醇过程; Cyc为任选取代的单核或多核的，饱和或不饱和的，碳环或杂环，且R

公开(公告)号：WO2004090124A3

公开(公告)日：2004-11-25

申请号：PCT/EP2004003844

申请日：2004-04-13

Applicant: BASF AG ,  FRIEDRICH THOMAS ,  KESSELER MARIA ,  HAUER BERNHARD

Inventor： FRIEDRICH THOMAS ,  KESSELER MARIA ,  HAUER BERNHARD

IPC: C12N9/88 ,  C12N15/60 ,  C12P13/00

CPC classification number: C12P13/004 ,  C12N9/88

Abstract: The present invention relates to new aminoacid sequences isolated from Adenia racemosa encoding S-hydroxynitrile lyases and their use in methods for the production of nitriles and/or carboxylic acids, preferably optically active nitriles and/or carboxylic acids. The invention further relates to nucleic acid encoding said S-hydroxynitrile lyases, recombinant expression constructs comprising said nucleic acid sequences, recombinant vectors comprising the nucleic acid sequences or the expression constructs, to recombinant organisms, preferably microorganisms or yeasts, comprising the nucleic acid sequences, expression constructs or vectors. The invention additionally relates to a method for the production of cyanohydrins and/or carboxylic acids, preferably optically active cyanohydrins and/or carboxylic acids from racemic aldehydes and cyanide.

Abstract translation: 本发明涉及从编码S-羟基腈裂解酶的Adenia racemosa分离的新的氨基酸序列及其在制备腈和/或羧酸，优选光学活性腈和/或羧酸的方法中的用途。 本发明还涉及编码所述S-羟基腈裂解酶的核酸，包含所述核酸序列的重组表达构建体，包含核酸序列或表达构建体的重组载体，重组生物，优选微生物或酵母，其包含核酸序列， 表达构建体或载体。 本发明还涉及从外消旋醛和氰化物制备氰醇和/或羧酸，优选光学活性的氰醇和/或羧酸的方法。

公开(公告)号：WO0107573A8

公开(公告)日：2001-04-05

申请号：PCT/EP0007251

申请日：2000-07-27

Applicant: BASF AG ,  HAUER BERNHARD ,  SCHMID ROLF D ,  SCHWANEBERG ULRICH

Inventor： HAUER BERNHARD ,  SCHMID ROLF D ,  SCHWANEBERG ULRICH

IPC: C12M1/40 ,  C12N1/21 ,  C12N9/02 ,  C12N15/09 ,  C12P7/02 ,  C12P7/04 ,  C12P7/22 ,  C12P7/42 ,  C12P7/64 ,  C12P17/10 ,  C12P17/16 ,  C12Q1/26 ,  C12R1/11 ,  C12R1/19 ,  C12N15/53 ,  C12N11/06 ,  C12N11/14

CPC classification number: C12P7/6409 ,  C12N9/0071 ,  C12N9/0077 ,  C12P7/02 ,  C12P7/04 ,  C12P7/22 ,  C12P7/42 ,  C12P17/10 ,  C12P17/165 ,  C12Q1/26 ,  G01N2333/90245

Abstract: The invention relates to a novel electron donor system for enzymes with redox properties and to its use in enzyme-catalyzed oxidation reactions, such as the production of omega hydroxylated fatty acids. The invention further relates to an improved analysis method for fatty acid monoxygenases and to bioreactors and test kits wherein the inventive electron donor system is advantageously used.

Abstract translation: 本发明涉及一种用于与氧化还原性质的酶的新型电子给体系统，其在酶催化的氧化反应，如在特定的产生ω羟基化脂肪酸的用途。 本发明还涉及一种用于Fettsäuremonoxygenasen，生物反应器和检验试剂盒的改进的检测方法，其中电子给体是有利的。

公开(公告)号：WO0107574A2

公开(公告)日：2001-02-01

申请号：PCT/EP0007252

申请日：2000-07-27

Applicant: BASF AG ,  HAUER BERNHARD ,  PLEISS JUERGEN ,  SCHWANEBERG ULRICH ,  SCHMITT JUTTA ,  FISCHER MARKUS ,  SCHMID ROLF ,  LI QING SHAN

Inventor： HAUER BERNHARD ,  PLEISS JUERGEN ,  SCHWANEBERG ULRICH ,  SCHMITT JUTTA ,  FISCHER MARKUS ,  SCHMID ROLF ,  LI QING-SHAN

IPC: C12M1/40 ,  C12N1/21 ,  C12N9/02 ,  C12N15/09 ,  C12P7/02 ,  C12P7/04 ,  C12P7/22 ,  C12P7/42 ,  C12P7/64 ,  C12P17/10 ,  C12P17/16 ,  C12Q1/26 ,  C12R1/11 ,  C12R1/19 ,  C12N9/00

CPC classification number: C12P7/6409 ,  C12N9/0071 ,  C12N9/0077 ,  C12P7/02 ,  C12P7/04 ,  C12P7/22 ,  C12P7/42 ,  C12P17/10 ,  C12P17/165 ,  C12Q1/26 ,  G01N2333/90245

Abstract: The invention relates to modified cytochrome P450 monooxygenases comprising a modified substrate profile, to nucleic acid sequences that code therefor, to expression constructs and vectors, and to recombinant microorganisms which contain these vectors. The invention also relates to methods for microbiologically producing terminally or subterminally hydroxylated aliphatic carboxylic acids.

Abstract translation: 本发明涉及具有改变的底物轮廓，编码核酸序列，表达构建体和载体，含有用于微生物生产终端或近hydroylierter脂族羧酸，这些载体和方法重组微生物修饰细胞色素P450单加氧酶。