公开(公告)号：WO2004089889A3

公开(公告)日：2005-06-02

申请号：PCT/EP2004003689

申请日：2004-04-07

Applicant: BASF AG ,  FRANKE DIRK ,  HILL FRIEDRICH ,  MARTIN CHRISTOPH ,  KNEBEL THOMAS

Inventor： FRANKE DIRK ,  HILL FRIEDRICH ,  MARTIN CHRISTOPH ,  KNEBEL THOMAS

IPC: A23L33/15 ,  C07D475/14 ,  A61K31/525

CPC classification number: C07D475/14 ,  A23L33/15

Abstract: The invention relates to an improved method for producing pure riboflavin (vitamin B2) of modification B/C in granular form. Also disclosed is pure riboflavin in granular form, said pure riboflavin being provided with a bulk density of 0.45 to 0.7 g/ml, which is to be determined according to DIN 53468, and dissolution kinetics of at least 80 percent after being tableted.

Abstract translation: 本发明涉及一种用于制备颗粒形式的变形例B / C的纯核黄素（维生素B2）的改进方法。 此外，本发明的至少80％的压片（溶解）后涉及纯核黄素在具有以按照DIN 0.45 53468堆积密度0.7克/毫升和溶解动力学来确定颗粒的形式。

公开(公告)号：DE10317051A1

公开(公告)日：2004-10-21

申请号：DE10317051

申请日：2003-04-11

Applicant: BASF AG

Inventor： FRANKE DIRK ,  HILL FRIEDRICH ,  MARTIN CHRISTOPH ,  KNEBEL THOMAS

IPC: A23L33/15 ,  C07D475/14 ,  A23L1/302 ,  A61K31/525

Abstract: The present invention relates to an improved process for preparing riboflavin of the B/C modification in granule form. Furthermore, the invention relates to the riboflavin preparation process wherein riboflavin of the A modification is (a) dissolved in aqueous mineral acid without treating the resulting riboflavin solution with activated carbon, (b) precipitated directly afterwards, steps (a) and (b) being carried out at a temperature in the range from 5 to 15° C., and (c) dried by fluidized bed granulation; and wherein the riboflavin does not come into contact with the aqueous mineral acid solvent for longer than on average 4 hours.

公开(公告)号：CA2521633A1

公开(公告)日：2004-10-21

申请号：CA2521633

申请日：2004-04-07

Applicant: BASF AG

Inventor： MARTIN CHRISTOPH ,  FRANKE DIRK ,  HILL FRIEDRICH ,  KNEBEL THOMAS

IPC: A23L33/15 ,  C07D475/14 ,  A61K31/525

Abstract: The invention relates to an improved method for producing pure riboflavin (vitamin B2) of modification B/C in granular form. Also disclosed is pure riboflavin in granular form, said pure riboflavin being provided with a bulk density of 0.45 to 0.7 g/ml, which is to be determined according to DIN 5346 8, and dissolution kinetics of at least 80 percent after being tableted.