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    1.
    发明专利
    未知

    公开(公告)号：DE59605774D1

    公开(公告)日：2000-09-28

    申请号：DE59605774

    申请日：1996-05-03

    Applicant: BASF AG

    Inventor： PAUST DR ,  JOHN DR

    IPC: C07C5/22 ,  C07C403/24 ,  C07F9/54

    Abstract: Prepn. of beta-carotene with a high 9(Z)-isomer content (formula (I)) is claimed. The 9(Z)- and 9(E) isomers of beta -ionylidenethyl triarylphosphonium salts (formulae II and VI respectively) are sepd. by aq. extn. and crystallisation. (I) may then be obtd. by reacting (II) and (III); or by reacting (II) and (IV) in presence of base to give (V) which is then reacted with (VI) in the presence of base to give (I). X = halide or (HSO4) and Ar = phenyl (opt. substd.). Also claimed is prepn. of (I) by thermal isomerisation of beta-carotene isolated or prepared by known methods.

    2.
    发明专利
    未知

    公开(公告)号：DE59508621D1

    公开(公告)日：2000-09-14

    申请号：DE59508621

    申请日：1995-09-23

    Applicant: BASF AG

    Inventor： KRAUSE DR ,  ERNST DR ,  PAUST DR ,  RHEUDE DR ,  DOBLER DR

    IPC: C07C67/307 ,  C07C69/65 ,  C07F9/40

    Abstract: Prodn. of trialkyl 4-phosphono-2-methyl-2-butenoate esters of formula (I) with a high E-isomer content comprises (a) reacting an alkyl 2-hydroxy-2-methyl-3-butenoate of formula (II) with PBr3 or PCl3 at 0-80 degrees C in the absence of pyridine to form a mixt. of an alkyl 4-halo-2- methyl-2-butenoate of formula (III) and an alkyl 2-halo-2-methyl-3-butenoate of formula (IV), and (b) reacting the mixt. with a trialkyl phosphite of formula (V) at 70-140 degrees C. R1, R2 = Me or Et; X = Cl or Br. Also claimed is the prodn. of (III) as in step (a) above at a temp. of 20-80 degrees C.

    3.
    发明专利
    未知

    公开(公告)号：DE59801069D1

    公开(公告)日：2001-08-30

    申请号：DE59801069

    申请日：1998-05-22

    Applicant: BASF AG

    Inventor： PAUST DR ,  KRIEGL WOLFGANG

    IPC: C07C403/24 ,  C07D493/08 ,  C07F9/50 ,  C07F9/54

    Abstract: Preparation of (3R,3'R)-zeaxanthin (I) comprises: (i) reacting (4R)-4-hydroxy-2,2,6-trimethyl-cyclohexanone (II) with dichloromethyl lithium in an inert solvent at -120 to -40 degrees C and warming the reaction mixture to 20-60 degrees C; (ii) reacting the obtained (4R,6R)-1-formyl-2,2,6-trimethyl-7-oxa-bicyclo (2.2.1) heptane of formula (IV) (in isolated form or directly in the reaction mixture) with acetone or a dialkyl (2-oxo-propyl)-phosphonate; (iii) converting the obtained (4R,6R)-1-(3-oxo-but-1-en-1-yl)-2,2,6-trimethyl-7-oxa-bicyclo (2.2.1) heptane of formula (V) into (4R,6R)-1-(3-hydroxy-3-methylpenta-1,4-dienyl)-2,2,6-trimethyl-7-oxa-b icyclo (2.2.1) heptane (VI) by conventional vinylation (or ethynylation followed by partial hydrogenation); (iv) reacting (VI) with a triaryl phosphine (preferably PPh3) and a strong acid to give a mixture of a C15 triaryl phosphonium salt of formula (III) and the isomer of formula (III'); and (v) subjecting 2 moles of the mixture to a double Wittig olefin synthesis reaction with 2,7-dimethyl-octa-2,4,6-triene-1,8-dial (VIII) to give (I). Ar = aryl (preferably optionally substituted phenyl); and X = 1 equivalent of an anion of a strong acid (preferably Cl, Br or HSO4). The preparation of (I) by step (v) is claimed per se. Also claimed are (IV) and (V) and (III') in mixtures with (III).

    6.
    发明专利
    未知

    公开(公告)号：DE50000905D1

    公开(公告)日：2003-01-23

    申请号：DE50000905

    申请日：2000-07-20

    Applicant: BASF AG

    Inventor： PAUST DR ,  ERNST DR ,  KACZMAREK DR ,  JAEDICKE DR

    IPC: C07B61/00 ,  C07C231/08 ,  C07C233/18 ,  C07C233/47 ,  C07C233/69 ,  C07C233/83

    Abstract: Preparation of N-acyl derivatives (I) using readily available starting materials. N-acyl derivatives of formula R -C(O)N(H)C(R )X (I) are prepared by reacting, in the presence of a compound of formula R -COOH (II), a carbonic acid amide of formula R -CONH2 (III) and a glyoxalmonoacetal derivative of formula R C(O)C(OR )OR (IV). R , R = H or optionally substituted alkyl or aryl; R ,R = 1 - 12C alkyl; and X = CH(OR ) or COOR . An Independent claim is also included for a compound of formula R -C(O)N(H)C(R )C(OR )OR (V).

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