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    PRODUCTION OF ENANTIOMERICALLY PURE BETA-HYDROXY ESTER
    2.
    发明专利
    PRODUCTION OF ENANTIOMERICALLY PURE BETA-HYDROXY ESTER 失效

    公开(公告)号：JP2000119217A

    公开(公告)日：2000-04-25

    申请号：JP27882199

    申请日：1999-09-30

    Applicant: BASF AG

    Inventor： STUERMER RAINER ,  KLATT MARTIN JOCHEN ,  BOERMER ARMIN ,  HOLZ JENS ,  VOSS GUDRUN

    IPC: B01J31/24 ,  C07B53/00 ,  C07B61/00 ,  C07C67/297 ,  C07C67/31 ,  C07C69/67 ,  C07C69/675 ,  C07C69/732

    Abstract: PROBLEM TO BE SOLVED: To provide a method for producing the subject β-hydroxy ester in high yield by reacting a β-keto ester with hydrogen in the presence of a ruthenium catalyst. SOLUTION: This method is to react (A) a β-keto ester with (B) hydrogen in the presence of (C) a catalyst of the formula, LRuX2 [X is a halogen, acetate or aryl; and L is a bidentate phospholane of the formula (B is an 1-6C crosslink between 2 Ps; R1 is H or an 1-6C alkyl or the like; R2 is alkyl or aryl; (m) is 0 or 1; and R3 is H or the like)], pref., at 0 to 100 deg.C under a pressure of 0.1 to 300 bars in an alkanol-containing solvent. The weight ratio of the component C to component A is pref. (1 to 10) to (1 to 1000,000). In the above reaction, it is preferable to add (D) 0.5 to 2 mol equivalents of acid esp. strong acid, (e.g. mineral acid or trifluoroacetic acid) to the component C.

    ENZYME-CONTAINING POLYMERS
    3.
    发明申请
    ENZYME-CONTAINING POLYMERS 审中-公开
    有机聚合物

    公开(公告)号：WO0005354A2

    公开(公告)日：2000-02-03

    申请号：PCT/EP9904590

    申请日：1999-07-02

    Applicant: BASF AG ,  STUERMER RAINER

    Inventor： STUERMER RAINER

    IPC: C12N9/96 ,  C08G18/83 ,  C12N11/08 ,  C12P41/00 ,  C12N11/00

    CPC classification number: C12N11/08

    Abstract: The present invention relates to novel enzyme-containing polymers, having at least one of the following structural elements (1 and 2), wherein the abbreviations and symbols have the following meaning: E stands for enzyme; X , X independently represent oxygen, sulfur or NH from a functional group of the enzyme; Q represents hydrogen or group (a); A , A , A , A independently represent oxygen or sulfur; p is 0 or 1 with the proviso that A , A , A and A represent oxygen when p = 0; w is 1-4; q is 1-4; v is 1-100; R represents an optionally substituted or functionalized hydrocarbon group with two to five bonds; R represents an optionally substituted or functionalized hydrocarbon group with two to five bonds; R and R independently represent hydrogen, a C1-C4-alkyl, aryl or alkylaryl group. The invention further relates to a method for the production of said enzyme-containing polymers, their utilization as catalysts in chemical reactions and their use for separating enantiomer mixtures.

    Abstract translation: 本发明涉及含有所述结构元件中的至少一个新颖的含酶的聚合物（1或2）其中的缩写和符号的含义如下：E：酶X <1>中，X <2>：独立地为氧，硫或NH从 该酶的官能团Q：氢或基团（a），A 1，A 2，A 3，A 4：独立地为氧或硫，p：0或1，与 当p = 0时，提供A 1，A 2，A 3，A 4氧，w：1-4，q：1-4，v：1-100，R 1：2至5元任选取代或官能化的烃基，R 2：2至5元任选取代或官能化的烃基，R 4和R 5独立地为 彼此氢，C1-C4烷基，芳基或烷芳基。 此外，本发明涉及一种用于制备含酶的聚合物，含酶的聚合物作为化学反应的催化剂和用于对映体混合物的分离中使用的含酶的聚合物的应用。

    CATALYTIC PATTERNS CONTAINING METAL COMPLEXES WITH AN ADAMANTANE-LIKE STRUCTURE
    5.
    发明申请
    CATALYTIC PATTERNS CONTAINING METAL COMPLEXES WITH AN ADAMANTANE-LIKE STRUCTURE 审中-公开
    催化剂体系包含金属配合物的ADAMANTANÄHNLICHER结构

    公开(公告)号：WO9816564A2

    公开(公告)日：1998-04-23

    申请号：PCT/EP9705201

    申请日：1997-09-23

    Applicant: BASF AG ,  GEPRAEGS MICHAEL ,  STUERMER RAINER ,  WEISS HORST ,  STEIGER SUSANNE

    Inventor： GEPRAEGS MICHAEL ,  STUERMER RAINER ,  WEISS HORST ,  STEIGER SUSANNE

    IPC: B01J31/22 ,  C08F4/602 ,  C08F4/642 ,  C08F4/645 ,  C08F10/00 ,  C08F12/00 ,  C08F12/04 ,  C08F210/02

    CPC classification number: C08F10/00 ,  C08F12/08 ,  C08F210/02 ,  C08F4/64072 ,  C08F212/08

    Abstract: The present invention relates to catalytic patterns, the active components of which are A) metal complexes of general formula (I), in which the substituents have the following notation: M is a metal of the subgroup III, IV, V or VI in the periodic table of the elements or a metal of the lanthanide series; Y is a negative nucleofuge atom or a negative leaving group; X and X are neutral atoms or negatively loaded atoms from the main group IV, V or VI in the periodic table of the elements; Z is hydrogen, C1- to C10-alkyl, C3- to C10-cycloalkyl, C1- to C10-alkoxy, C1- to C10-alkylthiolat or dialkylamide with, in each case, 1 to 4 C-atoms in the alkyl residues; R to R are hydrogen, organocarbon or organosilicon residues, n is 0, 1 or 2, the valence of M is (2+n), and B) a metallocenium-ionizing compound.

    Abstract translation: 包含作为活性成分A）（I）通式的金属配合物，其中取代基具有以下含义的催化剂体系：M是金属，V或III的VI，IV ... 元素或镧系的金属的周期表的子组; Y是负离去原子或负离去基团; X和X <1>为IV的带负电荷的或中性原子。，V。和VI。 元素的周期表主族; Z是氢，C1-C10烷基，C3至C10环烷基，C1至C10烷氧基，C1至C10烷基硫醇或烷基，R <1>至R <1至4个碳原子的二烷基酰胺具有 11>氢，碳 - 有机或有机硅基团，n为0，1或2，M（2 + n）和B）形成茂金属离子的化合物的化合价。

    METHOD FOR ENANTIOSELECTIVELY OPENING 3-SUBSTITUTED OXETAN-2-ONES UNDER THE ACTION OF LIPASES OF CANDIDA ANTARCTICA OR BURKHOLDERIA PLANTARRII
    6.
    发明申请
    METHOD FOR ENANTIOSELECTIVELY OPENING 3-SUBSTITUTED OXETAN-2-ONES UNDER THE ACTION OF LIPASES OF CANDIDA ANTARCTICA OR BURKHOLDERIA PLANTARRII 审中-公开
    脂肪酶南极洲念珠菌OR伯克霍尔德氏菌的影响下的3-取代氧杂环丁烷-2-酮类方法对映选择性OPENING

    公开(公告)号：WO2006015727A3

    公开(公告)日：2006-07-13

    申请号：PCT/EP2005008190

    申请日：2005-07-28

    Applicant: BASF AG ,  HABICHER TILO ,  STUERMER RAINER

    Inventor： HABICHER TILO ,  STUERMER RAINER

    IPC: C12P7/24 ,  C12P7/40 ,  C12P7/62 ,  C12P17/02 ,  C12P41/00

    CPC classification number: C12P41/001 ,  C12P7/24 ,  C12P7/40 ,  C12P7/62 ,  C12P17/02 ,  C12P41/003

    Abstract: The invention relates to a method for producing, in essence, enantiomer-pure 3-hydroxycarboxylic acids or esters of general formula (III) by reacting racemic oxetan-2-ones of general formula (I) with compounds R3-OH of general formula (II) in the presence of a lipase from Candida antarctica or Burkholderia plantarii, and separating the obtained products of formula (III) and (IV) from one another, and the radicals have the following meanings: R 1 , R 2 and R 3 , independent of one another, represent H, C 1 -C 10 -substituted or unsubstituted alkyl, and substituted or unsubstituted aryl or hetaryl, whereby R 1 and R 2 cannot have the same meaning at the same time.

    Abstract translation: 一种用于基本制备方法由通式（I）的化合物中，R通式3 -OH的外消旋氧杂环丁烷-2-酮反应，对映体纯的3-羟基羧酸或通式（III）的酯（II）中的脂肪酶的来自存在 南极假丝酵母或植物伯克霍尔德氏菌）式的（）中的产品III和反应（IV）中获得中隔离，其中，所述基团具有以下含义：R t 1 ，R 2 ，R 3 独立地表示H; ç 1 -C 10 - 取代或未取代的烷基，取代或未取代的芳基或杂芳基，其中R 1 和R 2 可能没有在同一时间相同的含义。

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