公开(公告)号：JPH1169992A

公开(公告)日：1999-03-16

申请号：JP18405598

申请日：1998-06-30

Applicant: BASF AG

Inventor： STUERMER RAINER ,  DITRICH KLAUS ,  SIEGEL WOLFGANG

IPC: C12P13/00 ,  C07C229/48 ,  C07C233/63 ,  C07C235/12 ,  C07C235/14 ,  C07C321/06 ,  C12P13/04 ,  C12P41/00

Abstract: PROBLEM TO BE SOLVED: To provide a method for resolution of racemic modification of an amino acid by an enzymatic catalytic reaction capable of assuring a high enantiomer reactivity, being used in a wide range of reaction conditions and requiring only a small amount of a catalyst as less as possible. SOLUTION: An optically active amino acid ester is produced from a racemic amino acid ester with an acid component as an acylating agent using a carboxylic acid ester containing a halogen atom, a nitrogen atom, an oxygen atom or a sulfur atom adjoining to a carbonyl carbon atom in the presence of a hydrolase selected from the group comprising an amidase, a protease, an esterase and a lipase and successively a nonacylated amino acid ester of an enantioselectively acylated amino acid ester is separated from another enantiomer.

公开(公告)号：JP2003113159A

公开(公告)日：2003-04-18

申请号：JP2002268971

申请日：2002-09-13

Applicant: BASF AG

Inventor： ERNST HANSGEORG ,  HENRICH KLAUS ,  DITRICH KLAUS

IPC: A61K31/045 ,  C07B61/00 ,  C07C29/74 ,  C07C35/17 ,  C07C35/18 ,  C07C43/196 ,  C07C47/21 ,  C07C47/225 ,  C07C69/013 ,  C07C69/14 ,  C07C69/16 ,  C07C69/63 ,  C07C69/65 ,  C07C403/08 ,  C07C403/24

Abstract: PROBLEM TO BE SOLVED: To provide a method for efficiently producing a meso-zeaxanthine in a high yield. SOLUTION: This method for producing the three-dimensionally homogeneous meso-zeaxanthine comprises (a) resolving a racemic mixture of acetylenediols (R-I) and (S-I) to enantiomers (R-I) and (S-I), (b) each converting the enantiomers (R-I) and (S-I) to 15C phosphonium salts (R-II) and (S-II), (c) reacting R-II or S-II with a 10C dialkylmonoacetal by Wittig reaction to provide 25C acetal R-IV or S-IV, (d) converting R-IV or S-IV to 25C aldehyde R-V or S-V and (e) reacting R-V with a 15C phosphonium salt S-II or reacting S-V with a 15C phosphonium salt R-II.

公开(公告)号：WO0138292A3

公开(公告)日：2002-02-28

申请号：PCT/EP0011191

申请日：2000-11-13

Applicant: BASF AG ,  DITRICH KLAUS ,  SIEGEL WOLFGANG

Inventor： DITRICH KLAUS ,  SIEGEL WOLFGANG

IPC: C12P41/00 ,  C07B55/00 ,  C07B57/00 ,  C07C209/58 ,  C07C209/86 ,  C07C213/00 ,  C07C215/08 ,  C07C217/10 ,  C07C235/08 ,  C07C213/08 ,  C07C213/10 ,  C12P13/00

CPC classification number: C07C217/10 ,  C07B2200/07 ,  C07C213/00 ,  C07C215/08 ,  C07C235/08

Abstract: The invention relates to a method for producing optically active amines. The invention also relates to a method for producing racemic amines, which can be racemically split using optically active carboxylic acids or enzymes. The invention additionally relates to racemic and optically active amines as well as to optically active amides.

Abstract translation: 本发明涉及一种用于生产光学活性胺。 此外，本发明涉及一种用于制备外消旋胺类，其可以与光学活性的羧酸或酶racematgespalten的处理。 本发明还涉及到外消旋的和光学活性的胺，以及光学活性的酰胺。

公开(公告)号：WO2007077118A2

公开(公告)日：2007-07-12

申请号：PCT/EP2006069862

申请日：2006-12-18

Applicant: BASF AG ,  DITRICH KLAUS ,  HAESE FRANK

Inventor： DITRICH KLAUS ,  HAESE FRANK

CPC classification number: C07D295/027

Abstract: The invention relates to a method for producing optically active trans-2,6-dimethylmorpholine by (i) reacting racemic trans-2,6-dimethylmorpholine with D-mandelic acid, (ii) separating the formed salt from D-mandelic acid and the one enantiomer of the trans-2,6-dimethylmorpholine from the other enantiomer of the trans-2,6-dimethylmorpholine and (iii) isolating the desired optically active trans-2,6-dimethylmorpholine.

Abstract translation: 一种用于通过（i）制备光学活性反式-2,6-二甲基吗啉外消旋的反式-2,6-二甲基反应，用（II）分离所得d-扁桃酸的盐和反式的一种对映体d扁桃酸处理 2,6-二甲基从所需的光学活性的反式-2,6-二甲基吗啉的反式-2,6-二甲基吗啉和（iii）隔离的另一对映体。

公开(公告)号：WO0238565A3

公开(公告)日：2003-10-09

申请号：PCT/EP0112977

申请日：2001-11-09

Applicant: BASF AG ,  TORMO I BLASCO JORDI ,  DITRICH KLAUS ,  SAUTER HUBERT ,  CULLMANN OLIVER ,  GEWEHR MARKUS ,  GRAMMENOS WASSILIOS ,  MUELLER BERND ,  GROTE THOMAS ,  GYPSER ANDREAS ,  RHEINHEIMER JOACHIM ,  ROSE INGO ,  SCHAEFER PETER ,  SCHIEWECK FRANK ,  AMMERMANN EBERHARD ,  STRATHMANN SIEGFRIED ,  LORENZ GISELA ,  STIERL REINHARD

Inventor： TORMO I BLASCO JORDI ,  DITRICH KLAUS ,  SAUTER HUBERT ,  CULLMANN OLIVER ,  GEWEHR MARKUS ,  GRAMMENOS WASSILIOS ,  MUELLER BERND ,  GROTE THOMAS ,  GYPSER ANDREAS ,  RHEINHEIMER JOACHIM ,  ROSE INGO ,  SCHAEFER PETER ,  SCHIEWECK FRANK ,  AMMERMANN EBERHARD ,  STRATHMANN SIEGFRIED ,  LORENZ GISELA ,  STIERL REINHARD

IPC: A01N43/90 ,  C07B53/00 ,  C07C209/62 ,  C07C211/03 ,  C07D487/04

CPC classification number: C07D487/04 ,  A01N43/90

Abstract: The invention relates to 7-(R) aminotriazolopyrimidines of formula (I), in which the substituents and index have the following definitions: R represents hydrogen or methyl; R represents methyl; R represents C2-C10 alkyl, C1-C4 alkoxymethyl, or C3-C10 cycloalkyl; R represents halogen, C1-C4 alkyl, C1-C4 haloalkyl or C1-C4 alkoxy; n represents a number between 1 and 5; Y represents halogen, cyano, C1-C4 alkyl or C1-C4 alkoxy; whereby * is a chirality centre with an R-configuration. The invention also relates to a method for producing said compounds, to agents containing the compounds and to the use thereof for combating harmful fungi.

Abstract translation: 7-（R）式（I）的-aminotriazolopyrimidine其中取代基和指数具有以下含义：R t <1>是氢或甲基; [R <2>是甲基; [R <3> C2-C10烷基，C1-C4烷氧基，C3-C10环烷基; [R <4>为卤素，C1-C4烷基，C1-C4卤代烷基或C1-C4烷氧基; n是从1到5的数; Y是卤素，氰基，C1-C4烷基或C1-C4烷氧基; 其中*是R构型的手性中心。 一种用于制备这些化合物，含有它们以及它们在防治有害真菌中的用途的组合物的过程。

公开(公告)号：CA2367897C

公开(公告)日：2009-10-13

申请号：CA2367897

申请日：2000-03-17

Applicant: BASF AG

Inventor： DITRICH KLAUS ,  LADNER WOLFGANG ,  MELDER JOHANN-PETER

IPC: C07C209/62 ,  C07B53/00 ,  C07C211/27 ,  C07C211/29

Abstract: The invention relates to a method for hydrolyzing optically active amides to carboxylic acids and optically active amines with retention of the center of chirality. The hydrolysis of the amides is carried out with an alkali or alkaline earth hydroxide in the presence of 5 - 30 wt.- %, based on the amide used, of a polyol or an amine alcohol.

公开(公告)号：DE102005062966A1

公开(公告)日：2007-07-05

申请号：DE102005062966

申请日：2005-12-28

Applicant: BASF AG

Inventor： DITRICH KLAUS ,  WINSEL HARALD ,  MOULIN DOMINIQUE

IPC: C07C229/38 ,  C07C227/34 ,  C12P13/04 ,  C12P41/00

Abstract: Production of optically active 4-(ammonium ethyl) benzoic acid methyl ester-sulfate (I) comprises reacting a racemic mixture of 4-(1-aminoethyl)-benzoic acid methyl ester with an acylating agent in the presence of lipase to give 4-(aminoethyl) benzoic acid methyl ester and subsequently precipitating 4-(ammonium ethyl)benzoic acid methyl ester-sulfate by adding sulfuric acid. Independent claims are included for: (1) (S)-4-(ammonium ethyl) benzoic acid methyl ester sulfate; and (2) (R)-4-(ammonium ethyl) benzoic acid methyl ester sulfate.

公开(公告)号：DE50011119D1

公开(公告)日：2005-10-13

申请号：DE50011119

申请日：2000-03-17

Applicant: BASF AG

Inventor： DITRICH KLAUS ,  LADNER WOLFGANG ,  MELDER JOHANN-PETER

IPC: C07B53/00 ,  C07C209/62 ,  C07C211/27 ,  C07C211/29

Abstract: The present invention relates to a process for hydrolyzing optically active amides to carboxylic acids and optically active amines with retention of the center of chirality, where the hydrolysis of the amides is carried out with an alkali metal or alkaline earth metal hydroxide in the presence of 5-30% by weight, based on the amide employed, of a polyol or an amino alcohol.

公开(公告)号：ES2235833T3

公开(公告)日：2005-07-16

申请号：ES00904982

申请日：2000-01-29

Applicant: BASF AG

Inventor： DITRICH KLAUS ,  BLOCK ULRICH

IPC: C07B61/00 ,  C07C51/48 ,  C07C59/125 ,  C07C67/08 ,  C07C67/54 ,  C07C69/708

Abstract: Procedimiento para la fabricación de ésteres de fórmula general I, **(Fórmula)** a partir de los compuestos contenidos en las disoluciones acuosas de fórmula general **(Fórmula)** caracterizado porque a) los compuestos de fórmula general II se extraen directamente o tras la liberación de sus sales en presencia de un alcohol C1-C8 y un disolvente no miscible con agua, en los que el alcohol se puede usar al mismo tiempo como disolvente y b) a continuación, se esterifican con el alcohol C1-C8 en presencia de un catalizador y un agente de arrastre cuyo punto de ebullición como azeótropo con el alcohol y el agua es al menos 8ºC menor que el azeótropo del alcohol y del agua, bajo las condiciones de una destilación azeotrópica, usándose al menos 1% en peso de agente de arrastre referido al volumen total de la reacción y en el que los pasos (a) y (b) del procedimiento pueden estar separados temporal y espacialmente o también se pueden realizar en una secuencia consecutiva continua o discontinua y en el que las variables y los sustituyentes en las fórmulas I y II tienen el significado siguiente: 35 R1 = F, Cl, -OH, -O-alquilo C1-C10 sustituido o no sustituido, ramificado o no ramificado, R2 = H, alquilo C1-C10 sustituido o no sustituido, ramificado o no ramificado, R3 = alquilo C1-C8 sustituido o no sustituido, ramificado o no ramificado, 40 Q = -OH, , -O-K+, en el que K+ es un ión alcalino o alcalinotérreo o una amina,

公开(公告)号：DK1119634T3

公开(公告)日：2004-06-28

申请号：DK99941616

申请日：1999-08-13

Applicant: BASF AG

Inventor： NUEBLING CHRISTOPH ,  DITRICH KLAUS ,  DULLY CHRISTIAN

IPC: C07C213/08 ,  C07C217/08 ,  C12P13/02 ,  C12P41/00

Abstract: The present invention relates to a process for resolving racemates of alkoxy-substituted primary amines by reacting with an ester in the presence of a lipase and subsequently separating the optically active amide which is formed from the unreacted optically active amine. This is followed where appropriate by hydrolysis of the optically active amide, separation of the optically active amine produced thereby from the acid from which the ester is derived, racemization and recycling of the unwanted enantiomer of the amine, and esterification and recycling of the acid.