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    Continuous preparation of an optically active carbonyl compound by asymmetric hydrogenation
    4.
    发明授权
    Continuous preparation of an optically active carbonyl compound by asymmetric hydrogenation 有权

    公开(公告)号：US11242306B2

    公开(公告)日：2022-02-08

    申请号：US17274142

    申请日：2019-09-03

    Applicant: BASF SE

    Inventor： Peter Zehner ,  Oliver Bey

    IPC: C07C45/62 ,  C07C29/00 ,  B01J19/00 ,  B01J19/18 ,  B01J31/24 ,  C07C29/17 ,  C07C31/04 ,  C07C33/14 ,  C07C47/21

    Abstract: Process for the continuous production of an optically active carbonyl compound by asymmetric hydrogenation of a prochiral α,β-unsaturated carbonyl compound with hydrogen in the presence of a homogeneous rhodium catalyst that has at least one chiral ligand, wherein a liquid reaction mixture comprising the prochiral α,β-unsaturated carbonyl compound is subjected in a first, backmixed reactor to a gas/liquid two-phase hydrogenation, and the liquid reaction mixture is then further hydrogenated in a second reactor, wherein the prochiral α,β-unsaturated carbonyl compound is employed in the first reactor in a concentration from 3% to 20% by weight. The process allows a high total conversion to the prochiral α,β-unsaturated carbonyl compound.

    Method for carrying out a gas/fluid two-phase high-pressure reaction
    7.
    发明授权
    Method for carrying out a gas/fluid two-phase high-pressure reaction 有权

    公开(公告)号：US11766653B2

    公开(公告)日：2023-09-26

    申请号：US17274110

    申请日：2019-09-03

    Applicant: BASF SE

    Inventor： Oliver Bey ,  Peter Zehner ,  Andreas Keller ,  Stephanie Renz ,  Mathias Schelwies ,  Rocco Paciello ,  Martin Haubner ,  Guenter Wegner ,  Gerd Tebben ,  Gunnar Heydrich ,  Georg Seeber

    IPC: C07C45/62 ,  B01J10/00 ,  B01J13/02 ,  B01J3/02 ,  B01J3/04 ,  B01J4/00 ,  B01J31/24 ,  C07B53/00

    CPC classification number: B01J10/002 ,  B01J3/02 ,  B01J3/042 ,  B01J4/002 ,  B01J31/2409 ,  C07C45/62 ,  B01J2203/065 ,  B01J2531/822 ,  C07B53/00

    Abstract: A process for performing a continuous gas/liquid biphasic high-pressure reaction, wherein a gas and a liquid are introduced into a backmixed zone of a reactor and in the backmixed zone the gas is dispersed in the liquid by stirring, injection of gas and/or a liquid jet, a reaction mixture consecutively traverses the backmixed zone and a zone of limited backmixing, and a liquid reaction product is withdrawn at a reaction product outlet of the zone of limited backmixing, wherein the reactor comprises: an interior formed by a cylindrical vertically oriented elongate shell, a bottom and a cap, wherein the interior is divided by means of internals into the backmixed zone, the zone of limited backmixing and a cavity, a first cylindrical internal element which in the interior extends in the longitudinal direction of the reactor and which delimits the zone of limited backmixing from the backmixed zone, backmixing-preventing second internal elements in the form of random packings, structured packings or liquid-permeable trays arranged in the zone of limited backmixing and a third internal element which in the interior extends in the longitudinal direction of the reactor and is open at the bottom, wherein the third internal element forms the cavity in which gas bubbles collect and do not escape upwards, thus preventing the volume of the cavity from being occupied by liquid and reducing the reaction volume. The reaction volume of the reactor used in the process can be reversibly reduced in simple fashion. The invention further relates to a process for adapting the reaction volume of a reactor suitable for performing a gas/liquid biphasic high-pressure reaction having an outlet for a liquid reaction product in which an internal element is arranged so as to form a cavity open at the bottom in which gas bubbles collect and do not escape upwards, thus preventing the volume of the cavity from being occupied by liquid and reducing the reaction volume.

    Method for synthesizing optically active carbonyl compounds
    8.
    再颁专利
    Method for synthesizing optically active carbonyl compounds 有权

    公开(公告)号：USRE49036E1

    公开(公告)日：2022-04-19

    申请号：US16521935

    申请日：2019-07-25

    Applicant: BASF SE

    Inventor： Mathias Schelwies ,  Rocco Paciello ,  Gunnar Heydrich ,  Günter Wegner ,  Gerd-Dieter Tebben ,  Martin Haubner ,  Andreas Keller ,  Oliver Bey ,  Stephanie Renz ,  Georg Seeber

    IPC: C07C45/62 ,  C07C29/17 ,  C07C29/56

    Abstract: The present invention relates to a process for the preparation of an optically active carbonyl compound by asymmetric hydrogenation of a prochiral α,β-unsaturated carbonyl compound with hydrogen in the presence of at least one optically active transition metal catalyst that is soluble in the reaction mixture and which has rhodium as catalytically active transition metal and a chiral, bidentate bisphosphine ligand, wherein the reaction mixture during the hydrogenation of the prochiral α,β-unsaturated carbonyl compound additionally comprises at least one compound of the general formula (I): in which R1, R2: are identical or different and are C6- to C10-aryl which is unsubstituted or carries one or more, e.g. 1, 2, 3, 4 or 5, substituents which are selected from C1- to C6-alkyl, C3- to C6-cycloalkyl, C6- to C10-aryl, C1- to C6-alkoxy and amino; Z is a group CHR3R4 or aryl which is unsubstituted or carries one or more, e.g. 1, 2, 3, 4 or 5, substituents which are selected from C1- to C6-alkyl, C3- to C6-cycloalkyl, C6- to C10-aryl, C1- to C6-alkoxy and amino, wherein R3 and R4 are as defined in the claims and the description.

    Cylindrical reactor and use thereof for continuous hydroformylation
    9.
    发明授权
    Cylindrical reactor and use thereof for continuous hydroformylation 有权

    公开(公告)号：US10315182B2

    公开(公告)日：2019-06-11

    申请号：US16064756

    申请日：2016-12-21

    Applicant: BASF SE

    Inventor： Rainer Papp ,  Oliver Christian Gobin ,  Oliver Bey ,  Jens Rudolph ,  Hans-Günter Thelen

    IPC: C07C45/50 ,  B01J10/00 ,  B01J19/24 ,  B01J19/00

    Abstract: Proposed is a cylindrical reactor (1) having a vertical longitudinal axis for continuous hydroformylation of a C6-C20-olefin or a mixture of C6-C20-olefins with synthesis gas in the presence of a homogeneously dissolved metal carbonyl complex catalyst, having a multiplicity of Field tubes (2) which are oriented parallel to the longitudinal axis of the reactor (1) and welded into a tube plate at the upper end of the reactor (1), having a circulation tube (3) open at both ends which envelops the Field tubes (2) and at its lower end projects beyond said tubes, having a jet nozzle (4) at the bottom of the reactor (1) for injecting the reactant mixture comprising the C6-C20-olefin, the synthesis gas and the metal carbonyl complex catalyst, wherein the Field tubes (2) are configured in terms of their number and their dimensions such that the total heat exchanger area of said tubes per unit internal volume of the reactor is in the range from 1 m2/m3 to 11 m2/m3 and the cross sectional area occupied by the Field tubes (2) per unit cross sectional area of the circulation tube (3) is in the range from 0.03 m2/m2 to 0.30 m2/m2, a gas distributor ring (5) is provided at the lower end of the circulation tube (3), at the inner wall thereof, via which a substream of the synthesis gas is feedable, and wherein one or more distributor trays (6) are provided in the circulation tube (3).

    Method for synthesizing optically active carbonyl compounds
    10.
    发明授权
    Method for synthesizing optically active carbonyl compounds 有权

    公开(公告)号：US10301244B2

    公开(公告)日：2019-05-28

    申请号：US15964400

    申请日：2018-04-27

    Applicant: BASF SE

    Inventor： Mathias Schelwies ,  Rocco Paciello ,  Gunnar Heydrich ,  Günter Wegner ,  Gerd-Dieter Tebben ,  Martin Haubner ,  Andreas Keller ,  Oliver Bey ,  Stephanie Renz ,  Georg Seeber

    IPC: C07C45/50 ,  C07C45/62 ,  C07C29/17 ,  C07C29/56

    Abstract: The present invention relates to a process for the preparation of an optically active carbonyl compound by asymmetric hydrogenation of a prochiral α,β-unsaturated carbonyl compound with hydrogen in the presence of at least one optically active transition metal catalyst that is soluble in the reaction mixture and which has rhodium as catalytically active transition metal and a chiral, bidentate bisphosphine ligand, wherein the reaction mixture during the hydrogenation of the prochiral α,β-unsaturated carbonyl compound additionally comprises at least one compound of the general formula (I): in which R1, R2: are identical or different and are C6- to C10-aryl which is unsubstituted or carries one or more, e.g. 1, 2, 3, 4 or 5, substituents which are selected from C1- to C6-alkyl, C3- to C6-cycloalkyl, C6- to C10-aryl, C1- to C6-alkoxy and amino; Z is a group CHR3R4 or aryl which is unsubstituted or carries one or more, e.g. 1, 2, 3, 4 or 5, substituents which are selected from C1- to C6-alkyl, C3- to C6-cycloalkyl, C6- to C10-aryl, C1- to C6-alkoxy and amino, wherein R3 and R4 are as defined in the claims and the description.

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