公开(公告)号：WO1996039464A1

公开(公告)日：1996-12-12

申请号：PCT/US1996010249

申请日：1996-06-06

Applicant: C.R. BARD, INC. ,  LEHIGH UNIVERSITY

Inventor： C.R. BARD, INC. ,  LEHIGH UNIVERSITY ,  VANDERHOFF, John, W. ,  LU, Cheng, Xun ,  LEE, Clarence, C. ,  TSAI, Chi-Chun

IPC: C08J03/26

CPC classification number: C08J3/26 ,  C08J3/05 ,  C08J3/16 ,  C08J2300/14

Abstract: A process for the preparation of crosslinked water-soluble polymer particles comprising, combining an aqueous polymer solution comprising a water-soluble polymer, particularly a polysaccharide, and an aqueous medium, and an oil medium so as to form an emulsion of droplets of the water-soluble polymer, and adding to the emulsion a crosslinking agent capable of crosslinking the water-soluble polymer so as to form crosslinked water-soluble polymer particles, the particles formed thereby and aqueous dispersions thereof. The invention also encompasses a method comprising, administering to a patient in need of treatment an aqueous suspension of the water-soluble polymer particles.

Abstract translation: 一种制备交联的水溶性聚合物颗粒的方法，包括将包含水溶性聚合物，特别是多糖和含水介质的水性聚合物溶液和油介质混合，以形成水滴的乳液 并且向该乳液中添加能够使水溶性聚合物交联以形成交联的水溶性聚合物颗粒的交联剂，由此形成的颗粒及其水分散体。 本发明还包括一种方法，其包括向需要治疗的患者施用水溶性聚合物颗粒的水性悬浮液。

公开(公告)号：WO1998020811A1

公开(公告)日：1998-05-22

申请号：PCT/US1997020642

申请日：1997-11-13

Applicant: C.R. BARD, INC.

Inventor： C.R. BARD, INC. ,  DWYER, Clifford, J. ,  ROBINSON, Timothy

IPC: A61F02/06

CPC classification number: A61F2/962 ,  A61F2002/9517 ,  A61F2002/9665

Abstract: A delivery catheter for delivering, orienting and releasing an endoprosthetic implant in a body lumen includes an elongate sheath adapted to maintain an expandable implant in a low profile configuration at the distal end of the sheath and a control handle at the proximal end of the sheath. An implant retainer is engageable with the trailing end of the implant and is connected to the handle. The implant retainer is controllably movable within the sheath to enable relative movement between the sheath and the implant. The sheath can be moved between a forward implant-capturing position in which the implant retention device is contained within the sheath and a rearward implant release position in which the implant retainer is disposed forwardly beyond the end of the sheath. A moveable mechanism associated with the handle includes detents to limit the extent of movement of the moveable portion of the handle to provide a sequential stage control that requires deliberate manipulation of the handle in order to progress from one stage of the delivery cycle to another.

Abstract translation: 用于在体腔内递送，定向和释放内假体植入物的递送导管包括细长护套，其适于将护发素的远端处的低轮廓构造的可扩张植入物保持在护套的近端处的控制手柄。 植入物保持器可与植入物的尾端接合并连接到手柄。 植入物保持器可控制地在护套内移动以使护套和植入物之间能够相对移动。 护套可以在其中植入物保持装置容纳在护套内的正向植入物捕获位置和向后植入物释放位置之间移动，其中植入物保持器向前设置在护套的端部之外。 与手柄相关联的可移动机构包括限制手柄的可移动部分的移动程度的棘爪，以提供顺序级控制，其需要对手柄进行有意的操纵，以便从输送周期的一个阶段进行到另一阶段。

公开(公告)号：WO1998000195A1

公开(公告)日：1998-01-08

申请号：PCT/US1997010824

申请日：1997-06-23

Applicant: C.R. BARD, INC.

Inventor： C.R. BARD, INC. ,  FAGAN, John, R. ,  ZHANG, John

IPC: A61M39/06

CPC classification number: A61B17/3462 ,  A61B17/3498 ,  A61M39/0606 ,  A61M2039/062 ,  A61M2039/0633 ,  A61M2039/0653 ,  A61M2039/0666 ,  A61M2039/0686

Abstract: A self-sealing hemostatic valve for use in a catheter apparatus is disclosed, comprising a proximal valve element having a sealing hole, a distal valve element having a flap and biasing means to enhance the force with which the flap bears against the distal side of the proximal valve element to normally seal the hole. The sealing hole seals about an instrument passed through the valve and the flap seals the valve when no instrument is present. The proximal face of the proximal valve element is provided with discontinuities that increase the flexibility of the proximal valve element in a distal direction.

Abstract translation: 公开了一种用于导管装置的自密封止血阀，其包括具有密封孔的近端阀元件，具有折片的远端阀元件和偏压装置，用于增强所述舌片抵靠所述导管的远端侧的力 近端阀元件以正常密封孔。 密封孔围绕通过阀门的仪器进行密封，当没有仪器存在时，挡板密封阀门。 近端阀元件的近端面设置有不连续性，其增加近端阀元件在远端方向上的柔性。

公开(公告)号：WO1997045068A1

公开(公告)日：1997-12-04

申请号：PCT/US1997009075

申请日：1997-05-30

Applicant: C.R. BARD, INC.

Inventor： C.R. BARD, INC. ,  ELDRIGDE, Stephen, N. ,  SHRINER, Kelly, N. ,  RUTKOW, Ira, M. ,  ROBBINS, Alan, W.

IPC: A61F02/00

CPC classification number: A61F2/0063 ,  A61B17/0057 ,  A61F2002/30205 ,  A61F2230/0067

Abstract: An implantable prosthesis for repairing or reconstructing a tissue or muscle wall defect including an outer plug and at least two inner filler plugs positioned within the outer plug that stiffen, and impart bulk to, the outer plug when the implant is inserted into the narrow confines of the tissue or muscle wall defect.

Abstract translation: 一种用于修复或重建组织或肌肉壁缺损的可植入假体，其包括外部塞子和位于外部塞子内的至少两个内部填充塞子，当将植入物插入到狭窄的狭窄区域 组织或肌肉壁缺损。

公开(公告)号：WO1997007848A1

公开(公告)日：1997-03-06

申请号：PCT/US1996014158

申请日：1996-08-23

Applicant: C.R. BARD, INC.

Inventor： C.R. BARD, INC. ,  BOWDEN, Russell, W. ,  FALWELL, Gary, S. ,  GIBSON, Charles, A. ,  STEVENS, Richard, B. ,  STEVENS-WRIGHT, Debbie, E.

IPC: A61M25/01

CPC classification number: A61M25/0144 ,  A61B18/1815 ,  A61B2017/003 ,  A61B2018/0016 ,  A61B2018/00916 ,  A61B2018/00946 ,  A61B2018/00952 ,  A61M25/0136 ,  A61M25/0141 ,  A61M25/0147

Abstract: A steerable catheter includes control handle having a generally tubular housing with a longitudinal slot therein in which an axially or longitudinally movable tow-part slideblock resides, and a generally cylindrical, rotatably mounted thumbwheel surrounding a distal portion of the tubular housing, for controlling the axial translation of the slideblock. The pullwire passes into the distal end of the control handle and is only secured to the proximal part of the two-part slideblock so as to prevent the user from placing the pullwire under compression. A tip radius adjusting wire is attached to and extends distally from a slide actuator in the control handle into and through the main catheter shaft portion. The free distal end of the tip radius adjusting wire is selectably locatable at different positions. The radius of curvature of the tip portion, when deflected, depends upon how far distally into the deflectable tip portion the radius adjusting wire has been advanced by the user. The electrode catheter thus has a deflectable tip whose radius of curvature is adjustable over a relatively wide range.

Abstract translation: 可操纵的导管包括控制手柄，其具有大致管状的壳体，其中具有纵向狭槽，其中轴向或纵向移动的牵引部件滑块位于其中，以及围绕管状壳体的远端部分的大致圆柱形可旋转地安装的指轮，用于控制轴向 幻灯片的翻译。 拉线进入控制手柄的远端，并且仅固定到两部分滑块的近端部分，以防止使用者将拉线放置在压缩状态。 尖端半径调节线附接到控制手柄中的滑块致动器并远离其延伸并且穿过主导管轴部分。 尖端半径调整线的自由端可选地位于不同位置。 尖端部分的弯曲半径在偏转时取决于使用者已经使半径调节线前进到可偏转尖端部分的远端。 因此，电极导管具有可偏转的尖端，其弯曲半径在相对宽的范围内是可调节的。

公开(公告)号：WO1994004216A1

公开(公告)日：1994-03-03

申请号：PCT/US1993007943

申请日：1993-08-24

Applicant: C.R. BARD, INC. ,  FITZMAURICE, Thomas, K. ,  DUANE, Patrick, J., E. ,  COLLINS, Denyse

Inventor： C.R. BARD, INC.

IPC: A61M29/02

CPC classification number: A61M25/104 ,  A61M25/09041 ,  A61M2025/0063 ,  A61M2025/0098 ,  A61M2025/0183 ,  A61M2025/1079

Abstract: A balloon dilatation catheter comprising an elongated tubular shaft and an inner tube defining inflation and guide wire lumens. A dilatation balloon is mounted on the distal end of the tubular shaft and communicates with the inflation lumen. The guide wire lumen extends through the balloon. A stiffening wire is positioned within the tubular shaft and has a proximal end secured in the proximal portion of the catheter. The distal end of the stiffening wire is anchored within the inner tube in an area adjacent the guide wire entrance port. The stiffening wire maximizes strength to the proximal portion of the catheter while maintaining flexibility in the distal end of the catheter as well as the balloon.

Abstract translation: 气囊扩张导管，其包括细长的管状轴和限定充气和导丝内腔的内管。 膨胀气囊安装在管状轴的远端并与膨胀腔连通。 导丝管腔延伸穿过气囊。 加强线定位在管状轴内，并且具有固定在导管的近端部分中的近端。 加强线的远端在与导丝线入口相邻的区域内锚定在内管内。 加强线使导管的近端部分的强度最大化，同时保持导管远端以及气囊的柔性。

公开(公告)号：WO1993005702A1

公开(公告)日：1993-04-01

申请号：PCT/US1992008199

申请日：1992-09-25

Applicant: C.R. BARD, INC.

Inventor： C.R. BARD, INC. ,  NESTOR, James, R. ,  HAUENSTEIN, Bennett, L.

IPC: A61B05/00

CPC classification number: A61B5/1495 ,  A61B5/1459 ,  A61B2562/085 ,  Y10T436/10 ,  Y10T436/102499

Abstract: A precalibrated sensing system for determining a blood parameter such as the partial pressures of oxygen (pO2) and carbon dioxide (pCO2), and the negative logarithm of hydrogen ion activity (pH). A dry sensor is provided which may be calibrated in the factory, packaged, sterilized and stored, without requiring recalibration prior to use.

公开(公告)号：WO1992020280A1

公开(公告)日：1992-11-26

申请号：PCT/US1992003967

申请日：1992-05-12

Applicant: C.R. BARD, INC.

Inventor： C.R. BARD, INC. ,  LOCK, James, E. ,  DAVIS, Randall, W.

IPC: A61B05/107

CPC classification number: A61B5/1076

Abstract: Products and methods for sizing openings in body cavities are provided. The products are catheters having compliant balloons attached to their distal ends and reference markers located on the catheter adjacent to the balloons. The preferred device is a cardiovascular sizing balloon for sizing septal defects and includes a latex balloon (14) with a proximal taper (24) and a pair of spaced-apart radiopaque bands (16) located immediately adjacent to the balloon.

Abstract translation: 提供了在体腔中定尺寸开口的产品和方法。 产品是具有附接到其远端的顺应性气囊的导管和位于邻近气囊的导管上的参考标记。 优选的装置是用于调整间隔缺损的心血管定型气囊，并且包括具有近端锥体（24）的乳胶球囊（14）和紧邻气囊的一对间隔开的不透射线带（16）。

公开(公告)号：WO1986006611A1

公开(公告)日：1986-11-20

申请号：PCT/US1986000935

申请日：1986-04-28

Applicant: C.R. BARD, INC.

Inventor： C.R. BARD, INC. ,  KULLAS, Karen, E. ,  GIUSTO, Joseph, D.

IPC: A61B19/00

CPC classification number: A61F5/003 ,  A61F5/0036

Abstract: An anti-obesity balloon and a placement system for the balloon includes a balloon (10) with a needle-pierceable, self-sealing plug (20) and an insertion catheter (12) having a needle (26) at its distal end. The needle (26) is movable between an extended position in which it protrudes distally of the insertion catheter (12) and a retracted position in which it is withdrawn interiorly of the insertion catheter (12). A handle arrangement (14) is provided at the proximal end of the insertion catheter to control the position of the needle (26). Means are provided for aspirating (16) and inflating (68) the balloon. The balloon structure (10) and insertion catheter structure (12) protect and enclose the sharp tip of the needle at all times during insertion and withdrawal of the insertion catheter (12). The insertion catheter (12) is detachable from the balloon (10), after the balloon (10) has been inflated in the patient's stomach, in a manner which imposes no force or load on the balloon.

公开(公告)号：WO1985003982A1

公开(公告)日：1985-09-12

申请号：PCT/US1985000351

申请日：1985-03-04

Applicant: C.R. BARD, INC.

Inventor： C.R. BARD, INC. ,  NEHRING, John, R.

IPC: F04B43/06

CPC classification number: F04B43/06

Abstract: A two-stroke pumping device for developing pulsatile fluid flow includes a housing with an internal resilient flexible element (66). The flexible element defines a pair of chambers within the housing, including a pumping chamber (62) and a driving chamber (64). The pumping chamber is connected to a source of the fluid to be pumped and the driving chamber is connected to a pneumatic pressure source adapted to create a pressure differential across the flexible element. The device includes a means responsive to the flexure of the element in the ejection stroke to terminate that stroke and begin the filling stroke. The flexible element oscillates to generate repetitive ejection and filling strokes.

Abstract translation: 用于显影脉动流体流的二冲程泵送装置包括具有内部弹性柔性元件（66）的壳体。 柔性元件在壳体内限定一对腔室，包括泵送室（62）和驱动室（64）。 泵送室连接到要泵送的流体的源，并且驱动室连接到适于在柔性元件上产生压力差的气动压力源。 该装置包括响应于在排出行程中元件的弯曲的装置来终止该冲程并开始填充冲程。 柔性元件振荡以产生重复的喷射和填充冲程。