公开(公告)号：WO2004000721A3

公开(公告)日：2005-02-03

申请号：PCT/US0319775

申请日：2003-06-23

Applicant: FLUIDIGM CORP ,  MANGER IAN D ,  BARCO JOSEPH W ,  NASSEF HANY R

Inventor： MANGER IAN D ,  BARCO JOSEPH W ,  NASSEF HANY R

IPC: B01L3/00 ,  B81C20060101 ,  F04B19/00 ,  F04B43/02 ,  G01N21/00 ,  G01N33/53 ,  G01N33/543 ,  G01N33/566 ,  G01N37/00

CPC classification number: B81B3/00 ,  B01L3/5025 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/088 ,  B01L2300/0887 ,  B01L2400/0415 ,  B01L2400/0481 ,  B01L2400/0655 ,  F04B19/006 ,  F04B43/02 ,  F16K99/0001 ,  F16K99/0003 ,  F16K99/0026 ,  F16K99/0036 ,  F16K99/0046 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0084 ,  G01N33/5304 ,  G01N33/54366 ,  Y10T436/2575

Abstract: The present invention provides microfluidic devices comprising elastomeric components and solid substrate component for attaching ligands and methods for conducting a variety of assays and high throughput screening. The elastomeric components comprise a plurality of first and second flow channels forming a plurality of intersecting areas, further capable of forming looped flow channels, and in fluid communication with the solid substrate surface, a plurality of control channels, a plurality of first and second control valves, and a plurality of loop forming control valves.

Abstract translation: 本发明提供了包含弹性体组分和用于附着配体的固体底物组分和用于进行各种测定和高通量筛选的方法的微流体装置。 弹性体部件包括形成多个相交区域的多个第一和第二流动通道，其还能够形成环形流动通道，并且与固体基板表面流体连通，多个控制通道，多个第一和第二控制 阀和多个回路成形控制阀。

公开(公告)号：AU2003277853A8

公开(公告)日：2004-01-06

申请号：AU2003277853

申请日：2003-06-23

Applicant: FLUIDIGM CORP

Inventor： BARCO JOSEPH W ,  NASSEF HANY R ,  MANGER IAN D

IPC: B01L3/00 ,  B81C20060101 ,  F04B19/00 ,  F04B43/02 ,  G01N21/00 ,  G01N33/53 ,  G01N33/543 ,  G01N33/566 ,  G01N37/00

Abstract: A microfluidic device includes a plurality of first flow channels and a plurality of second flow channels, each such second flow channel intersecting multiple of the first flow channels to define intersecting volumes and a plurality of looped flow channels that each include segments of the flow channels between the intersecting volumes to define a closed loop. The microfluidic device also includes a plurality of control valves each such control valve having a control channel and a deformable segment disposed to restrict flow through a respective one of the first and second flow channels in response to an actuation force applied to the control channel to deflect the deformable segment. The microfluidic device further includes a pump operatively disposed to regulate flow through one of the looped flow channels to regulate flow by the recirculating pump.

公开(公告)号：AU2003277853A1

公开(公告)日：2004-01-06

申请号：AU2003277853

申请日：2003-06-23

Applicant: FLUIDIGM CORP

Inventor： MANGER IAN D ,  BARCO JOSEPH W ,  NASSEF HANY R

IPC: B01L3/00 ,  B81C20060101 ,  F04B19/00 ,  F04B43/02 ,  G01N21/00 ,  G01N33/53 ,  G01N33/543 ,  G01N33/566 ,  G01N37/00

Abstract: A microfluidic device includes a plurality of first flow channels and a plurality of second flow channels, each such second flow channel intersecting multiple of the first flow channels to define intersecting volumes and a plurality of looped flow channels that each include segments of the flow channels between the intersecting volumes to define a closed loop. The microfluidic device also includes a plurality of control valves each such control valve having a control channel and a deformable segment disposed to restrict flow through a respective one of the first and second flow channels in response to an actuation force applied to the control channel to deflect the deformable segment. The microfluidic device further includes a pump operatively disposed to regulate flow through one of the looped flow channels to regulate flow by the recirculating pump.