公开(公告)号：WO2004103563A2

公开(公告)日：2004-12-02

申请号：PCT/US2004016115

申请日：2004-05-20

Applicant: FLUIDIGM CORP ,  QUAN EMERSON ,  TAYLOR COLIN JON ,  LEE MICHAEL ,  CEASAR CHRISTOPHER ,  HARRIS GREG

Inventor： QUAN EMERSON ,  TAYLOR COLIN JON ,  LEE MICHAEL ,  CEASAR CHRISTOPHER ,  HARRIS GREG

IPC: B01L3/00 ,  B01L

CPC classification number: G01N33/00 ,  B01L3/5025 ,  B01L3/502707 ,  B01L2200/025 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0481 ,  B01L2400/0655 ,  Y10T436/11

Abstract: A biological substrate, e.g., microfluidic chip. The substrate includes a rigid substrate material, which has a surface region capable of acting as a handle substrate. The substrate also has a deformable fluid layer coupled to the surface region. One or more well regions are formed in a first portion of the deformable fluid layer and are capable of holding a fluid therein. The one or more channel regions are formed in a second portion of the deformable fluid layer and are coupled to one or more of the well regions. An active region is formed in the deformable fluid layer. At least three fiducial markings are formed within the non-active region and disposed in a spatial manner associated with at least one of the well regions. A control layer is coupled to the fluid layer.

Abstract translation: 生物底物，例如微流体芯片。 衬底包括刚性衬底材料，其具有能够用作手柄衬底的表面区域。 衬底还具有耦合到表面区域的可变形流体层。 一个或多个阱区域形成在可变形流体层的第一部分中并且能够在其中保持流体。 一个或多个通道区域形成在可变形流体层的第二部分中并且耦合到一个或多个阱区域。 在可变形流体层中形成有源区。 在非有源区域内形成至少三个基准标记，并以与至少一个阱区域相关联的空间方式设置。 控制层耦合到流体层。

公开(公告)号：WO0200343A3

公开(公告)日：2002-06-06

申请号：PCT/US0120639

申请日：2001-06-27

Applicant: FLUIDIGM CORP

Inventor： LEE MICHAEL ,  WORTHINGTON GAJUS ,  HARRIS GREGORY ,  MONTGOMERY JAMES

IPC: B01F13/00 ,  B01F15/00 ,  B01L3/00 ,  B81B1/00 ,  B81C99/00 ,  G06F17/50

CPC classification number: G06F17/50 ,  B01F13/0059 ,  B01F15/00824 ,  B01F15/00935 ,  B01J2219/00997 ,  B01L3/5027 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/12 ,  B81B1/00 ,  B81C99/006 ,  G06F17/509 ,  G06F2217/16 ,  H01H2029/008

Abstract: The design of customized microfluidic systems using a CAD system (10) is disclosed. In one embodiment, a microfluidic circuit design method (200) is provided. The method includes developing synthesizable computer code for the design. Next, a microfluidic circuit schematic, including a plurality of symbols for microfluidic components, is generated either interactively or using the synthesizable computer code. The microfluidic circuit schematic is then functionally simulated. The microfluidic components are placed and routed (430) on a template to form a physical layout. Then the physical layout (410) is physically simulated (800) using dynamic simulation models of the microfluidic components; and the physical layout is written to a layout file (900).

Abstract translation: 公开了使用CAD系统（10）的定制微流体系统的设计。 在一个实施例中，提供了微流体电路设计方法（200）。 该方法包括为设计开发可合成的计算机代码。 接下来，以交互方式或使用可合成计算机代码生成包括用于微流体组分的多个符号的微流体电路示意图。 然后功能性模拟微流体电路原理图。 将微流体组件放置并布线（430）在模板上以形成物理布局。 然后使用微流体组件的动态仿真模型物理模拟（800）物理布局（410） 并将物理布局写入布局文件（900）。

公开(公告)号：CA2526368A1

公开(公告)日：2004-12-02

申请号：CA2526368

申请日：2004-05-20

Applicant: FLUIDIGM CORP

Inventor： TAYLOR COLIN JON ,  LEE MICHAEL ,  SUN GANG ,  QUAN EMERSON CHUENG ,  CEASAR CHRISTOPHER G ,  HARRIS GREG

IPC: B01L3/00 ,  B29D11/00 ,  B44C1/22 ,  C02F1/40 ,  F15C1/04 ,  F15C1/06 ,  G01N21/00 ,  G01N33/558 ,  G01N35/02

Abstract: A biological substrate, e.g., microfluidic chip. The substrate includes a rigid substrate material, which has a surface region capable of acting as a handle substrate. The substrate also has a deformable fluid layer coupled to the surface region. One or more well regions are formed in a first portion of the deformable fluid layer and are capable of holding a fluid therein. The one or more channel regions are formed in a second portion of the deformable fluid layer and are coupled to one or more of the well regions. An active region is formed in the deformable fluid layer. At least three fiducial markings are formed within the non-active region and disposed in a spatial manner associated with at least one of the well regions. A control layer is coupled to the fluid layer.

公开(公告)号：AU7305701A

公开(公告)日：2002-01-08

申请号：AU7305701

申请日：2001-06-27

Applicant: FLUIDIGM CORP

Inventor： LEE MICHAEL ,  WORTHINGTON GAJUS ,  HARRIS GREGORY ,  MONTGOMERY JAMES

IPC: B01F13/00 ,  B01F15/00 ,  B01L3/00 ,  B81B1/00 ,  B81C99/00 ,  G06F17/50

Abstract: The present invention generally relates to microfluidics and more particularly to the design of customized microfluidic systems using a microfluidic computer aided design system. In one embodiment of the present invention a microfluidic circuit design method is provided. The method includes developing synthesizable computer code for a design. Next, a microfluidic circuit schematic, including a plurality of symbols for microfluidic components, is generated either interactively or using the synthesizable computer code. The microfluidic circuit schematic is then functionally simulated. The microfluidic components are placed and routed on a template to form a physical layout. Then the physical layout is physically simulated using dynamic simulation models of the microfluidic components; and the physical layout is written to a layout file.

公开(公告)号：AU2004240944A1

公开(公告)日：2004-12-02

申请号：AU2004240944

申请日：2004-05-20

Applicant: FLUIDIGM CORP

Inventor： TAYLOR COLIN JON ,  CEASAR CHRISTOPHER ,  SUN GANG ,  QUAN EMERSON CHUENG ,  HARRIS GREG ,  LEE MICHAEL

IPC: B29D11/00 ,  B44C1/22 ,  C02F1/40 ,  F15C1/04 ,  F15C1/06 ,  G01N21/00 ,  G01N33/558 ,  G01N35/02 ,  B01L3/00

Abstract: A biological substrate, e.g., microfluidic chip. The substrate includes a rigid substrate material, which has a surface region capable of acting as a handle substrate. The substrate also has a deformable fluid layer coupled to the surface region. One or more well regions are formed in a first portion of the deformable fluid layer and are capable of holding a fluid therein. The one or more channel regions are formed in a second portion of the deformable fluid layer and are coupled to one or more of the well regions. An active region is formed in the deformable fluid layer. At least three fiducial markings are formed within the non-active region and disposed in a spatial manner associated with at least one of the well regions. A control layer is coupled to the fluid layer.