公开(公告)号：US3772327A

公开(公告)日：1973-11-13

申请号：US3772327D

申请日：1971-07-27

Applicant: HOFFMANN LA ROCHE

Inventor： BROSSI A ,  KLOETZER W ,  TEITEL S

IPC: C07D317/60 ,  C07D13/10

CPC classification number: C07D317/60

Abstract: THE PRESENT INVENTION RELATES TO THE PREPARATION OF NOVEL RHEADAN-TYPE ALKALOIDS AND TO NOVEL INTERMEDIATES USEFUL IN THE PREPARATION THEOF. THE PROCESS UTILIZES AS STARTING MATERIALS A KNOWN CLASS OF ALKALOIDS OF THE NARCOTINE OR OF THE HYDRASTINE TYPE. CERTAIN OF THE SAID NOVEL INTERMEDIATES ARE ALSO PHARMACEUTICALLY USEFUL IN AND OF THEMSELVES. ADDITIONALLY, CERTAIN OF THE NOVEL INTERMEDIATES CAN BE CONVERTED INTO OTHER TYPE ALKALOIDS WHICH ARE ALSO PHARMACEUTICALLY USEFUL.

公开(公告)号：US3819725A

公开(公告)日：1974-06-25

申请号：US18120071

申请日：1971-09-16

Applicant: HOFFMANN LA ROCHE

Inventor： BROSSI A ,  FOCELLA A ,  TEITEL S

IPC: C07C37/50 ,  C07C45/71 ,  C07C49/753 ,  C07C39/08

CPC classification number: C07C49/753 ,  C07C37/00 ,  C07C37/055 ,  C07C37/07 ,  C07C37/50 ,  C07C45/71 ,  C07C39/08

Abstract: PREPARATION OF 5-ALKYL SUBSTITUTED RESORCINOLS SUCH AS OLIVETOL FROM ALIPHATIC ALDEHYDES AND INTERMEDIATES IN THIS PROCESS.

公开(公告)号：US3729519A

公开(公告)日：1973-04-24

申请号：US3729519D

申请日：1971-09-17

Applicant: HOFFMANN LA ROCHE

Inventor： TEITEL S ,  BROSSI A ,  FOCELLA A

IPC: C07C43/205 ,  C07C45/63 ,  C07C45/66 ,  C07C45/67 ,  C07C45/71 ,  C07C45/72 ,  C07C45/74 ,  C07C49/203 ,  C07C49/753 ,  C07C43/22 ,  C07C41/00

CPC classification number: C07C41/06 ,  C07C37/00 ,  C07C37/07 ,  C07C37/50 ,  C07C43/2055 ,  C07C45/63 ,  C07C45/66 ,  C07C45/676 ,  C07C45/71 ,  C07C45/72 ,  C07C45/74 ,  C07C49/713 ,  C07C49/203 ,  C07C49/755 ,  C07C49/753 ,  C07C49/17 ,  C07C39/08 ,  C07C39/245

Abstract: PREPARATION OF 5-ALKYL SUBSTITUTED RESORCINOLS SUCH AS OLIVETOL FROM ALIPHATIC ALDEHYDE AND INTERMEDIATES IN THIS PROCESS.

公开(公告)号：US3838181A

公开(公告)日：1974-09-24

申请号：US18125471

申请日：1971-09-16

Applicant: HOFFMANN LA ROCHE

Inventor： BROSSI A ,  FOCELLA A ,  TEITEL S

IPC: C07C37/50 ,  C07C45/63 ,  C07C45/67 ,  C07C45/71 ,  C07C45/74 ,  C07C49/753 ,  C07C39/08

CPC classification number: C07C49/753 ,  C07C37/00 ,  C07C37/055 ,  C07C37/07 ,  C07C37/50 ,  C07C45/63 ,  C07C45/676 ,  C07C45/71 ,  C07C45/74 ,  C07C49/713 ,  C07C49/203 ,  C07C39/08

Abstract: PREPARATION OF 5-ALKYL SUBSTITUTED RESORCINOLS SUCH AS OLIVETOL FROM ALIPHATIC ALDEHYDES AND INTERMEDIATES IN THIS PROCESS.

公开(公告)号：US3790636A

公开(公告)日：1974-02-05

申请号：US3790636D

申请日：1971-09-16

Applicant: HOFFMANN LA ROCHE

Inventor： BROSSI A ,  FOCELLA A ,  TEITEL S

IPC: C07C37/055 ,  C07C37/07 ,  C07C37/50 ,  C07C39/24 ,  C07C45/63 ,  C07C45/67 ,  C07C45/71 ,  C07C45/74 ,  C07C49/753 ,  C07C49/60

CPC classification number: C07C49/753 ,  C07C37/00 ,  C07C37/055 ,  C07C37/07 ,  C07C37/50 ,  C07C45/63 ,  C07C45/676 ,  C07C45/71 ,  C07C45/74 ,  C07C49/713 ,  C07C49/203 ,  C07C39/08 ,  C07C39/245

Abstract: PREPARATION OF 5-ALKYL SUBSTITUTED RESORCINOLS SUCH AS OLIVETOL FROM ALIPHATIC ALDEHYDES AND INTERMEDIATES IN THIS PROCESS.

公开(公告)号：US3751487A

公开(公告)日：1973-08-07

申请号：US3751487D

申请日：1969-12-11

Applicant: HOFFMANN LA ROCHE

Inventor： BROSSI A ,  PECHERER B

IPC: C07C43/205 ,  C07C69/76 ,  C07D223/18 ,  C07C43/22

CPC classification number: C07D223/18 ,  C07C43/205 ,  C07C69/76

Abstract: SUBSTITUTED DIBENZO(C,E)AZEPINES AND DIBENZO(D,F) AZONINES, PREPARED THROUGH VARIOUS SEQUENTIAL INTERMEDIATES, FOR EXAMPLE, STARTING WITH A COMPOUND OF THE FORMULA

1-(2-Y,3,5-DI(O=)CYCLOHEX-1-YL),2-R4,3-R2,4-R1,5-R2-

BENZENE

WHEREIN R1, R2, R3, R4 AND Y ARE AS DEFINED HEREINAFTER, ARE DESCRIBED. THE END PRODUCTS ARE USEFUL AS HYPOTENSIVE AGENTS.

公开(公告)号：US3850997A

公开(公告)日：1974-11-26

申请号：US18122771

申请日：1971-09-16

Applicant: HOFFMANN LA ROCHE

Inventor： BROSSI A ,  FOCELLA A ,  TEITEL S

IPC: C07C39/24 ,  C07C43/205 ,  C07C45/71 ,  C07C45/74 ,  C07C49/753

CPC classification number: C07C39/245 ,  C07C43/2055

Abstract: 1. THE COMPOUND 2-CHLORO-5-N-PENTYLRESORCINOL.

公开(公告)号：US3824272A

公开(公告)日：1974-07-16

申请号：US18125871

申请日：1971-09-16

Applicant: HOFFMANN LA ROCHE

Inventor： BROSSI A ,  FOCELLA A ,  TEITEL S

IPC: C07C37/50 ,  C07C45/71 ,  C07C49/753 ,  C07C61/36

CPC classification number: C07C49/753 ,  C07C37/00 ,  C07C37/055 ,  C07C37/07 ,  C07C37/50 ,  C07C45/71 ,  C07C39/08

Abstract: PREPARATION OF 5-ALKYL SUBSTITUTED RESORCINOLS SUCH AS OLIVETOL FROM ALIPHATIC ALDEHYDES AND INTERMEDIATES IN THIS PROCESS.

公开(公告)号：US3795683A

公开(公告)日：1974-03-05

申请号：US3795683D

申请日：1970-08-19

Applicant: HOFFMANN LA ROCHE

Inventor： BROSSI A ,  PECHERER B ,  SUNBURY R

IPC: C07C233/45 ,  C07D223/16 ,  C07D225/06 ,  C07D227/08 ,  C07D317/50 ,  C07D317/58 ,  C07D317/60 ,  C07D491/04 ,  C07D13/10

CPC classification number: C07D223/16 ,  C07C255/00 ,  C07D317/58 ,  C07D317/60 ,  C07D491/04 ,  Y02P20/55 ,  Y10S514/96 ,  Y10S514/962

Abstract: A PROCESS FOR THE PREPARATION OF HETEROCYCLIC COMPOUNDS CONTAINING ONE NITROGEN ATOM AND NOVEL 2,3,4,5TETRAHYDRO-1H-3-BENZAZEPINES PREPARED BY THIS PROCESS ARE DISCLOSED. THE RESULTING HETEROCYCLIC COMPOUNDS, INCLUDING THE NOVEL 2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE DERIVATIVES, EXHIBIT ANALGESIC, APPETITE SUPPRESSANT, AND ANTI-EDEMA ACTIVITY.

公开(公告)号：ZA7303251B

公开(公告)日：1974-02-27

申请号：ZA7303251

申请日：1973-05-14

Applicant: HOFFMANN LA ROCHE

Inventor： BROSSI A ,  FOCELLA A ,  TEITEL S

IPC: C07D317/64 ,  C07D405/06 ,  C07D

CPC classification number: C07D405/06