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公开(公告)号：US3772413A
公开(公告)日：1973-11-13
申请号：US3772413D
申请日：1971-10-08
Applicant: HOFFMANN LA ROCHE
Inventor： BRETSCHNEIDER H , KLOETZER W , FRANZMAIR R
IPC: C07D207/22 , C07D207/26 , C07D27/04
CPC classification number: C07D207/26 , C07D207/22 , Y10S514/866
Abstract: NOVEL 2-IMINOPYRROLIDINES SUBSTITUTED IN THE 1-POSITION ARE PREPARED FROM 2-AMINO-$''-PYRROLINES. THE NOVEL PYRROLIDINES ARE USEFUL AS ANTI-DIABETIC AND HYPOGLYCEMIC AGENTS SINCE THEY EFFECT A LOWERING OF THE BLOOD SUGAR CONTENT IN WARM BLOODED ANIMALS.
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公开(公告)号：US3772327A
公开(公告)日：1973-11-13
申请号：US3772327D
申请日：1971-07-27
Applicant: HOFFMANN LA ROCHE
Inventor： BROSSI A , KLOETZER W , TEITEL S
IPC: C07D317/60 , C07D13/10
CPC classification number: C07D317/60
Abstract: THE PRESENT INVENTION RELATES TO THE PREPARATION OF NOVEL RHEADAN-TYPE ALKALOIDS AND TO NOVEL INTERMEDIATES USEFUL IN THE PREPARATION THEOF. THE PROCESS UTILIZES AS STARTING MATERIALS A KNOWN CLASS OF ALKALOIDS OF THE NARCOTINE OR OF THE HYDRASTINE TYPE. CERTAIN OF THE SAID NOVEL INTERMEDIATES ARE ALSO PHARMACEUTICALLY USEFUL IN AND OF THEMSELVES. ADDITIONALLY, CERTAIN OF THE NOVEL INTERMEDIATES CAN BE CONVERTED INTO OTHER TYPE ALKALOIDS WHICH ARE ALSO PHARMACEUTICALLY USEFUL.
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公开(公告)号：NO136410B
公开(公告)日：1977-05-23
申请号：NO79973
申请日：1973-02-27
Applicant: HOFFMANN LA ROCHE
Inventor： BRETSCHNEIDER H , KLOETZER W , BADER G , LUTZ A
IPC: A61K31/415 , A61P3/08 , C07D207/22 , C07D403/12 , C07D487/14
Abstract: 3-Methyl-N-(1-pyrrolin-2-yl)-pyrazole-5-carboxamides and processes for making same. Such compounds lower blood sugar and, hence, are useful as antidiabetic agents.
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公开(公告)号：ZA73149B
公开(公告)日：1973-10-31
申请号：ZA73149
申请日：1973-01-09
Applicant: HOFFMANN LA ROCHE
Inventor： BADER G , LUTZ A , BRETSCHNEIDER H , KLOETZER W
IPC: A61K31/415 , A61P3/08 , C07D207/22 , C07D403/12 , C07D487/14 , C07D
Abstract: 3-Methyl-N-(1-pyrrolin-2-yl)-pyrazole-5-carboxamides and processes for making same. Such compounds lower blood sugar and, hence, are useful as antidiabetic agents.
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公开(公告)号：SE300986B
公开(公告)日：1968-05-20
申请号：SE901864
申请日：1964-07-24
Applicant: HOFFMANN LA ROCHE
Inventor： BRETSCHNEIDER H , FITZ E , KLOETZER W
IPC: B01J10/02 , B01J19/20 , B01J19/24 , B04C5/081 , C07D261/14 , C07D261/16 , C08G69/04 , C07D85/24
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Patent Agency Ranking
公开(公告)号：YU46444B
公开(公告)日：1993-10-20
申请号：YU40388
申请日：1988-03-01
Applicant: HOFFMANN LA ROCHE
Inventor： KLOETZER W , MONTAVON M , MUESSNER R , SINGEWALD N
IPC: C07D233/56 , A61K31/415 , A61K31/4164 , A61K31/417 , A61P3/00 , A61P29/00 , C07D233/61 , C07D233/64 , C07D233/80 , C07D233/84 , C07D233/88 , C07D521/00
Abstract: POSTUPAK ZA IZRADU DERIVATA IMIDAZOLA, opšte formule u kojoj R(na prvi stepen) i R(na drugi stepen) označavaju alkil sa 1 do 4 C-atoma, R(na peti stepen) označava vodonik ili alkil sa 1 do 4 C-atoma, dok R(na šesti stepen) označava vodonik, alkil sa 1 do 4 C-atoma, alkiltio sa 1 do 4 C-atoma ili morfolinoi njihovih fermaceutski prihvatljivih kiselinskih adicionih soli, naznačen time, što se jedinjenje opšte formule u kojoj R(na prvi stepen), R(na drugi stepen), R(na peti stepen) i R(na šesti stepen) imaju gore navedeno značenje redukuje katalitičkom hidrogenizacijom u prisustvu katalizatora kao što je paladijm u inertnom organskom rastvaraču kao što je metanol na sobnoj temperaturi i pri normalnom pritisku uz celishodno dodavanje kiseline kao što je hlorovodonična kiselina ili pomoću kompleksnog hidrida kao što je natrijum cijanoborhidrid u pogodnom rastvaraču kao što je glacijalna sirćetna kiselina na sobnoj temperaturi i normalnom pritisku.
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公开(公告)号：DK129657B
公开(公告)日：1974-11-04
申请号：DK83473
申请日：1973-02-16
Applicant: HOFFMANN LA ROCHE
Inventor： BRETSCHNEIDER H , KLOETZER W , BADER G , LUTZ A
IPC: A61K31/415 , A61P3/08 , C07D207/22 , C07D403/12 , C07D487/14 , C07D57/00
Abstract: 3-Methyl-N-(1-pyrrolin-2-yl)-pyrazole-5-carboxamides and processes for making same. Such compounds lower blood sugar and, hence, are useful as antidiabetic agents.
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公开(公告)号：BE783188A
公开(公告)日：1972-11-09
申请号：BE783188
申请日：1972-05-09
Applicant: HOFFMANN LA ROCHE
Inventor： BROSSI A , KLOETZER W , TEITEL S
IPC: C07D223/16 , C07D317/60 , C07D317/64 , C07D491/04 , C07D491/14 , C07D491/22 , C07D , A61K
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公开(公告)号：SE320368B
公开(公告)日：1970-02-09
申请号：SE396566
申请日：1966-03-25
Applicant: HOFFMANN LA ROCHE
Inventor： BRETSCHNEIDER H , FITZ E , KLOETZER W
IPC: B01J10/02 , B01J19/20 , B01J19/24 , B04C5/081 , C07D261/14 , C07D261/16 , C08G69/04 , C07D85/22
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公开(公告)号：ZA7300149B
公开(公告)日：1973-10-31
申请号：ZA7300149
申请日：1973-01-09
Applicant: HOFFMANN LA ROCHE
Inventor： BADER G , LUTZ A , BRETSCHNEIDER H , KLOETZER W
IPC: A61K31/415 , A61P3/08 , C07D207/22 , C07D403/12 , C07D487/14 , C07D
CPC classification number: C07D403/12 , C07D207/22 , Y10S514/866
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