公开(公告)号：US20230366824A1

公开(公告)日：2023-11-16

申请号：US18317677

申请日：2023-05-15

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Eun-Ah YOU ,  Jae-Eul SHIM ,  Young Jun KIM

IPC: G01N21/65 ,  G01N33/569 ,  G01N33/543 ,  G01N33/563

CPC classification number: G01N21/658 ,  G01N33/56983 ,  G01N33/543 ,  G01N33/563 ,  G01N2021/656 ,  G01N2469/20

Abstract: Provided is a digital surface-enhanced Raman scattering (SERS) sensing platform which allows quantitative detection of a substance to be detected reliably and reproducibly with an excellent limit of detection in a large dynamic range, including: a surface-enhanced Raman scattering (SERS) active reagent which includes Raman active particles including a spherical plasmonic metal core, a plasmonic metal shell having a surface unevenness, and a self-assembled monolayer including a Raman reporter positioned between the core and the shell; a Raman spectroscopic detection unit which performs Raman mapping based on a Raman spectrum which is detected by irradiating the active reagent with an excitation light; and a digital signal analysis unit which analyzes a quantitative detection signal of a substance to be detected by a combination of a Raman signal intensity calculated from the Raman spectrum and a digital count calculated from the Raman mapping.