公开(公告)号：US20210331933A1

公开(公告)日：2021-10-28

申请号：US16498307

申请日：2018-10-23

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Eun-Ah YOU ,  Wansun KIM ,  Tae Geol LEE

IPC: C01G7/00 ,  G01N21/65

Abstract: Provided is a method of preparing composite nanoparticles, which includes: a) preparing a metal nanocore having a nano-star shape from a first reaction solution in which a first metal precursor is mixed with a first buffer solution; b) fixing a Raman reporter in the metal nanocore; and c) forming a metal shell, which surrounds the nanocore in which the Raman reporter is fixed, from a second reaction solution in which the nanocore in which the Raman reporter is fixed, and a second metal precursor are mixed with a second buffer solution.

公开(公告)号：US20230168201A1

公开(公告)日：2023-06-01

申请号：US17587541

申请日：2022-01-28

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE ,  VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

Inventor： Eun-Ah YOU ,  Zhou WEI ,  Wonil NAM ,  Wansun KIM

IPC: G01N21/65 ,  G01N33/68

CPC classification number: G01N21/658 ,  G01N33/6896 ,  B82Y40/00

Abstract: The present disclosure relates to a surface-enhanced Raman spectroscopy complex probe capable of effectively detecting a catecholamine compound even at extremely low concentrations. The complex probe includes a nanolaminate including a nanogap and metal nanoparticles. In this case, the nanolaminate and the metal nanoparticles are modified to a compound that may be bound to each functional group included in catecholamine, and thus, catecholamine included in an analyte is doubly recognized by the complex probe. In addition, since a hotspot emitting a strong SERS signal is formed by a nanogap included in a nanolaminate, it is possible to effectively detect a catecholamine compound even at extremely low concentrations.

公开(公告)号：US20210364509A1

公开(公告)日：2021-11-25

申请号：US16498326

申请日：2018-10-10

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Eun-Ah YOU ,  Wansun KIM ,  Tae Geol LEE

IPC: G01N33/543 ,  G01N33/553

Abstract: Provided is a method of preparing Raman-active nanoparticles, which includes a) preparing a metal nanocore having a nano-star shape from a first reaction solution in which a first metal precursor is mixed with a buffer solution; b) fixing a Raman reporter in the metal nanocore; and c) forming a metal shell, which surrounds the nanocore in which the Raman reporter is fixed, from a second reaction solution in which a second metal precursor is mixed with the nanocore in which the Raman reporter is fixed. The Raman reporter has a binding affinity for each of a first metal of the metal nanocore and a second metal of the metal shell.

公开(公告)号：US20170106394A1

公开(公告)日：2017-04-20

申请号：US14892900

申请日：2015-05-19

Applicant: Korea Research Institute of Standards and Science

Inventor： Eun-Ah YOU

IPC: B05C3/02 ,  B05C13/02

CPC classification number: B05C3/02 ,  B05C3/04 ,  B05C13/02 ,  C25D17/00

Abstract: An apparatus for dipping a substrate includes: a body having an internal plate formed therein, and including a backing plate 120 provided over the internal plate; a crucible accommodating an aqueous solution therein and provided over the backing plate; a crucible driving unit provided in the body and connected to the crucible so as to move the crucible in a horizontal direction or a vertical direction of the body; a support having a lower end to which a substrate is fixed; a support driving unit provided to an upper side of the body and connected to the support so as to drive the support in a length direction of the support or rotate the support in the vertical direction of the body; and a controlling unit connected to the crucible driving unit and the support driving unit to control driving of the crucible driving unit and the support driving unit.

公开(公告)号：US20230366824A1

公开(公告)日：2023-11-16

申请号：US18317677

申请日：2023-05-15

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Eun-Ah YOU ,  Jae-Eul SHIM ,  Young Jun KIM

IPC: G01N21/65 ,  G01N33/569 ,  G01N33/543 ,  G01N33/563

CPC classification number: G01N21/658 ,  G01N33/56983 ,  G01N33/543 ,  G01N33/563 ,  G01N2021/656 ,  G01N2469/20

Abstract: Provided is a digital surface-enhanced Raman scattering (SERS) sensing platform which allows quantitative detection of a substance to be detected reliably and reproducibly with an excellent limit of detection in a large dynamic range, including: a surface-enhanced Raman scattering (SERS) active reagent which includes Raman active particles including a spherical plasmonic metal core, a plasmonic metal shell having a surface unevenness, and a self-assembled monolayer including a Raman reporter positioned between the core and the shell; a Raman spectroscopic detection unit which performs Raman mapping based on a Raman spectrum which is detected by irradiating the active reagent with an excitation light; and a digital signal analysis unit which analyzes a quantitative detection signal of a substance to be detected by a combination of a Raman signal intensity calculated from the Raman spectrum and a digital count calculated from the Raman mapping.

公开(公告)号：US20220349826A1

公开(公告)日：2022-11-03

申请号：US17723855

申请日：2022-04-19

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Eun-Ah YOU ,  Jae-Eul SHIM ,  Tae Geol LEE

IPC: G01N21/65

Abstract: Provided is a Raman-active nanoparticle including: a spherical plasmonic metal core; a plasmonic metal shell having surface irregularities; and a self-assembled monolayer which binds to each of the core and the shell, is positioned between the core and the shell, and includes a Raman reporter satisfying the following Chemical Formula 1: NO2—Ar—SH  (Chemical Formula 1) wherein Ar is a (C6-C12) arylene group.

公开(公告)号：US20180188646A1

公开(公告)日：2018-07-05

申请号：US15306990

申请日：2015-09-25

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Eun-Ah YOU

IPC: G03F7/00 ,  G01N21/65 ,  G03F7/16 ,  G03F7/20 ,  G03F7/26 ,  G03F7/039 ,  B29D11/00

CPC classification number: G03F7/0005 ,  B29D11/0074 ,  B29K2075/00 ,  B29K2883/00 ,  G01N21/658 ,  G03F7/039 ,  G03F7/16 ,  G03F7/2002 ,  G03F7/26

Abstract: Provided is a method for manufacturing a transparent substrate according to an exemplary embodiment of the present invention including: a) forming a photoresist layer satisfying D=m*(λ/2n); b) manufacturing a ring-shaped pattern by exposing the photoresist layer and developing the exposed photoresist layer, using a photo mask including a transparent base and a plate-type metal dot formed contacting a light emitting surface of the transparent base; c) manufacturing a second mold to which the ring-shaped pattern is reversely transferred by using a substrate on which the ring-shaped pattern is formed as a first mold; and d) manufacturing the transparent substrate in which a ring-shaped transparent protrusion is integrally formed with the transparent base by filling a liquefied transparent resin in the second mold and curing the transparent resin and removing the second mold to transfer the ring-shaped pattern.