公开(公告)号：EP4197559A1

公开(公告)日：2023-06-21

申请号：EP20949578.7

申请日：2020-08-14

Applicant: Korea Institute of Science and Technology

Inventor： KIM, Sun Hwa ,  KWON, Ick Chan ,  KIM, In-San ,  KIM, Kwangmeyung ,  YANG, Yoosoo ,  KO, Young-ji

IPC: A61K47/64 ,  A61K47/65 ,  A61K31/713 ,  A61P35/00 ,  C12N15/115

Abstract: A fusion protein-siRNA complex according to the present disclosure binds specifically to cancer cells, is taken up effectively by the cells, and exhibits anticancer activity as it is degraded by lysosomes. The fusion protein-siRNA complex provides maximized anticancer activity so that the cancer cells can be removed by autoimmunity, by inhibiting the immunity of the cancer cells and enhancing phagocytosis by macrophages.