公开(公告)号：CA2040457A1

公开(公告)日：1991-10-31

申请号：CA2040457

申请日：1991-04-15

Applicant: LONG TIMOTHY E ,  TEEGARDEN DAVID M

Inventor： LONG TIMOTHY E ,  TEEGARDEN DAVID M

IPC: C08F297/04 ,  C08F297/02 ,  C08F293/00

Abstract: BLOCK COPOLYMERS CONTAINING POLY(1,3-CONJUGATED DIENES) AND POLY(VINYLPHENOLS), SILYL PROTECTED POLY(VINYLPHENOLS) OR POLY(METAL PHENOLATES) Diblock and triblock copolymers are disclosed consisting of a poly(l,3-conjugated diene) block and a block of a poly(vinylphenol), a silyl protected poly(vinylphenol), or a poly(metal phenolate).

公开(公告)号：CA2075465A1

公开(公告)日：1993-02-27

申请号：CA2075465

申请日：1992-08-12

Applicant: MASSA DENNIS J ,  TEEGARDEN DAVID M ,  COLBY RALPH H ,  LANDRY CHRISTINE J T ,  LANDRY MICHAEL R ,  LONG TIMOTHY E

Inventor： MASSA DENNIS J ,  TEEGARDEN DAVID M ,  COLBY RALPH H ,  LANDRY CHRISTINE J T ,  LANDRY MICHAEL R ,  LONG TIMOTHY E

IPC: C08L25/18 ,  C08L67/00 ,  C08L67/02 ,  C08L25/04 ,  C08L29/02 ,  C08L33/12

Abstract: POLYESTER/POLY(VINYLPHENOL) BLENDS A miscible blend is disclosed. The blend includes a) a thermoplastic polyester wherein the diacid component of said polyester includes aromatic groups and wherein the diol component of said polyester comprises at least about 20 mole percent of a noncyclic, aliphatic diol and b) a vinylphenol containing polymer; wherein components a) and b) are present in relative proportions by weight within the range of from about 1:99 to 99:1 parts based on 100 parts of the combined components a) and b).

公开(公告)号：CA2074912A1

公开(公告)日：1993-02-27

申请号：CA2074912

申请日：1992-07-29

Applicant: COLBY RALPH H ,  LANDRY CHRISTINE J T ,  LANDRY MICHAEL R ,  LONG TIMOTHY E ,  MASSA DENNIS J ,  TEEGARDEN DAVID M

Inventor： COLBY RALPH H ,  LANDRY CHRISTINE J T ,  LANDRY MICHAEL R ,  LONG TIMOTHY E ,  MASSA DENNIS J ,  TEEGARDEN DAVID M

IPC: C08L25/00 ,  C08L25/18 ,  C08L67/00 ,  C08L67/02 ,  C08L69/00 ,  C08L71/00 ,  C08L71/12 ,  C08L51/00 ,  C08L53/00

Abstract: COMPATIBLE POLYESTER BLENDS There is disclosed a blend of certain polyesters and polymers that are miscible with polystyrene, such as polyphenylene oxide. The blend is characterized by the presence of a compatibilizing amount of a copolymer having repeating units derived from an aromatic vinyl compound monomer and a vinylphenol monomer. The polyester is thermoplastic and is characterized in that the diacid component of the polyester includes aromatic groups and the diol component comprises at least about 20 percent by weight of a noncyclic, aliphatic diol.

公开(公告)号：WO2012174543A2

公开(公告)日：2012-12-20

申请号：PCT/US2012042974

申请日：2012-06-18

Applicant: VIRGINIA TECH INTELL PROP ,  HEMP SEAN T ,  ALLEN MICHAEL H ,  SMITH ADAM E ,  LONG TIMOTHY E

Inventor： HEMP SEAN T ,  ALLEN MICHAEL H ,  SMITH ADAM E ,  LONG TIMOTHY E

IPC: C08F230/02 ,  A61K48/00 ,  C08F212/08 ,  C08F220/10 ,  C08L43/02

CPC classification number: C08F12/26 ,  A61K48/00 ,  C08F12/14 ,  C08F230/02 ,  C08F293/005 ,  C08F2220/286 ,  C08F2438/03 ,  C12N15/87

Abstract: The present invention provides compositions comprising polymers and biologically active compounds, especially polymeric drug delivery systems. More specifically, the present invention provides ammonium and/or phosphonium-containing polymers and/or block copolymers as a viable and improved option for gene delivery. In an embodiment, the present invention provides a method of using a composition comprising a block copolymer that comprises: a stabilization block and a complexation block, and optionally an endosomolytic block for nonviral gene delivery. Preferred compositions include such co-polymers, wherein the complexation block is chosen from polymers of styrenic-based phosphonium-containing monomers chosen from: (F) wherein X is phosphorus; R is Cl-24 alkyl; and n is a number ranging from 2 to 1,000.

Abstract translation: 本发明提供了包含聚合物和生物活性化合物，特别是聚合物药物递送系统的组合物。 更具体地，本发明提供了含铵和/或鏻聚合物和/或嵌段共聚物作为基因递送的可行和改进的选择。 在一个实施方案中，本发明提供了使用包含嵌段共聚物的组合物的方法，所述组合物包含：稳定嵌段和络合嵌段，以及任选的用于非病毒基因递送的内体积分解块。 优选的组合物包括这样的共聚物，其中络合嵌段选自选自以下的苯乙烯类鏻单体的聚合物：（F）其中X是磷; R是C 1-4烷基; n为2〜1000的数。