公开(公告)号：CA2852283A1

公开(公告)日：2015-11-27

申请号：CA2852283

申请日：2014-05-27

Applicant: SMITH ADAM E

Inventor： SMITH ADAM E

IPC: B60P3/06

公开(公告)号：WO2012174543A2

公开(公告)日：2012-12-20

申请号：PCT/US2012042974

申请日：2012-06-18

Applicant: VIRGINIA TECH INTELL PROP ,  HEMP SEAN T ,  ALLEN MICHAEL H ,  SMITH ADAM E ,  LONG TIMOTHY E

Inventor： HEMP SEAN T ,  ALLEN MICHAEL H ,  SMITH ADAM E ,  LONG TIMOTHY E

IPC: C08F230/02 ,  A61K48/00 ,  C08F212/08 ,  C08F220/10 ,  C08L43/02

CPC classification number: C08F12/26 ,  A61K48/00 ,  C08F12/14 ,  C08F230/02 ,  C08F293/005 ,  C08F2220/286 ,  C08F2438/03 ,  C12N15/87

Abstract: The present invention provides compositions comprising polymers and biologically active compounds, especially polymeric drug delivery systems. More specifically, the present invention provides ammonium and/or phosphonium-containing polymers and/or block copolymers as a viable and improved option for gene delivery. In an embodiment, the present invention provides a method of using a composition comprising a block copolymer that comprises: a stabilization block and a complexation block, and optionally an endosomolytic block for nonviral gene delivery. Preferred compositions include such co-polymers, wherein the complexation block is chosen from polymers of styrenic-based phosphonium-containing monomers chosen from: (F) wherein X is phosphorus; R is Cl-24 alkyl; and n is a number ranging from 2 to 1,000.

Abstract translation: 本发明提供了包含聚合物和生物活性化合物，特别是聚合物药物递送系统的组合物。 更具体地，本发明提供了含铵和/或鏻聚合物和/或嵌段共聚物作为基因递送的可行和改进的选择。 在一个实施方案中，本发明提供了使用包含嵌段共聚物的组合物的方法，所述组合物包含：稳定嵌段和络合嵌段，以及任选的用于非病毒基因递送的内体积分解块。 优选的组合物包括这样的共聚物，其中络合嵌段选自选自以下的苯乙烯类鏻单体的聚合物：（F）其中X是磷; R是C 1-4烷基; n为2〜1000的数。

公开(公告)号：WO2012174543A3

公开(公告)日：2012-12-20

申请号：PCT/US2012/042974

申请日：2012-06-18

Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. ,  HEMP, Sean, T. ,  ALLEN, Michael, H. ,  SMITH, Adam, E. ,  LONG, Timothy, E.

Inventor： HEMP, Sean, T. ,  ALLEN, Michael, H. ,  SMITH, Adam, E. ,  LONG, Timothy, E.

IPC: C08F230/02 ,  C08F220/10 ,  C08F212/08 ,  C08L43/02 ,  A61K48/00

Abstract: The present invention provides compositions comprising polymers and biologically active compounds, especially polymeric drug delivery systems. More specifically, the present invention provides ammonium and/or phosphonium-containing polymers and/or block copolymers as a viable and improved option for gene delivery. In an embodiment, the present invention provides a method of using a composition comprising a block copolymer that comprises: a stabilization block and a complexation block, and optionally an endosomolytic block for nonviral gene delivery. Preferred compositions include such co-polymers, wherein the complexation block is chosen from polymers of styrenic-based phosphonium-containing monomers chosen from: (F) wherein X is phosphorus; R is Cl-24 alkyl; and n is a number ranging from 2 to 1,000.