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    4.
    发明专利
    未知

    公开(公告)号：AT302407T

    公开(公告)日：2005-09-15

    申请号：AT96917957

    申请日：1996-06-04

    Applicant: MASIMO CORP

    Inventor： LEPPER JAMES M JR ,  DIAB MOHAMED KHEIR

    IPC: G01N21/35 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/31 ,  G02B7/00 ,  G02B26/00

    Abstract: A blood glucose monitoring system includes a broadband light source and a specially fabricated optical filter for modulating optical radiation to be transmitted through a fleshy medium. Optical radiation which passes through the fleshy medium is detected by an optical detector which generates an electrical signal indicative of the intensity of the detected light. Digital signal processing is performed on the electrical signal to extract those optical characteristics of the electrical signal due to the optical characteristics of the filter and constituents of the fleshy May 1, 1995 medium other than blood glucose concentration. The monitoring system employs a unique "double-log" transformation to minimize errors due to indeterminate path length variations of the optical radiation through the fleshy medium. The monitoring system further employs specialized signal processing to avoid inaccuracies due to the previously unidentified solvent effect which arises when glucose is dissolved into water.

    5.
    发明专利
    未知

    公开(公告)号：PT832421E

    公开(公告)日：2002-12-31

    申请号：PT96917089

    申请日：1996-06-04

    Applicant: MASIMO CORP

    Inventor： KIANI-AZARBAYJANY ESMAIEL ,  DIAB MOHAMED KHEIR ,  RAGSDALE CHARLES ROBERT ,  LEPPEER JAMES M

    IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495 ,  G01J3/10 ,  G01J3/28 ,  G01N21/01 ,  G01N21/25 ,  G01N21/27 ,  G01N21/39 ,  G01N21/64 ,  G05F3/08 ,  H05B37/02

    Abstract: The method and apparatus of the present invention provides a system wherein light-emitting diodes (LEDs) (162) can be tuned within a given range by selecting their operating drive current in order to obtain a precise wavelength. The present invention further provides a manner in which to calibrate and utilize an LED probe (150), such that the shift in wavelength for a known change in drive current is a known quantity. In general, the principle of wavelength shift for current drive changes for LEDs is utilized in order to allow better calibration and added flexibility in the use of LED sensors, particularly in applications when the precise wavelength is needed in order to obtain accurate measurements. The present invention also provides a system in which it is not necessary to know precise wavelengths of LEDs where precise wavelengths were needed in the past. Finally, the present invention provides a method and apparatus for determining the operating wavelength of a light-emitting element such a light-emitting diode.

    Blood glucose monitoring system
    7.
    发明专利
    Blood glucose monitoring system 未知

    公开(公告)号：AU715345B2

    公开(公告)日：2000-01-20

    申请号：AU6033296

    申请日：1996-06-04

    Applicant: MASIMO CORP

    Inventor： LEPPER JAMES M JR ,  DIAB MOHAMED KHEIR

    IPC: G01N21/35 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/31 ,  G02B7/00 ,  G02B26/00

    Abstract: A blood glucose monitoring system includes a broadband light source and a specially fabricated optical filter for modulating optical radiation to be transmitted through a fleshy medium. Optical radiation which passes through the fleshy medium is detected by an optical detector which generates an electrical signal indicative of the intensity of the detected light. Digital signal processing is performed on the electrical signal to extract those optical characteristics of the electrical signal due to the optical characteristics of the filter and constituents of the fleshy May 1, 1995 medium other than blood glucose concentration. The monitoring system employs a unique "double-log" transformation to minimize errors due to indeterminate path length variations of the optical radiation through the fleshy medium. The monitoring system further employs specialized signal processing to avoid inaccuracies due to the previously unidentified solvent effect which arises when glucose is dissolved into water.

    Optical filter for spectroscopic measurement and method of producing the optical filter
    8.
    发明专利
    Optical filter for spectroscopic measurement and method of producing the optical filter 未知

    公开(公告)号：AU706049B2

    公开(公告)日：1999-06-10

    申请号：AU6036796

    申请日：1996-06-04

    Applicant: MASIMO CORP

    Inventor： LEPPER JAMES M O JR ,  DIAB MOHAMED KHEIR

    IPC: G01J3/12 ,  G01J3/26 ,  G01N21/31 ,  G02B5/20 ,  G02B5/28

    Abstract: An optical filter used in applications involving spectroscopic measurements is fabricated by depositing layers of optical coatings onto a substrate. The layers are deposited so as to have a substantially constant thickness in a first direction along the surface of the substrate, and a gradually increasing thickness along a direction perpendicular to the first direction. The structure of the optical filter allows for large scale production of the filter so that costs in producing the filter are greatly reduced. The filter may be used in a variety of applications including, but not limited to chemical analysis, blood glucose monitoring, and the like.

    ACTIVE PULSE BLOOD CONSTITUENT MONITORING
    9.
    发明专利
    ACTIVE PULSE BLOOD CONSTITUENT MONITORING 未知

    公开(公告)号：CA2221864C

    公开(公告)日：2008-08-19

    申请号：CA2221864

    申请日：1996-06-04

    Applicant: MASIMO CORP

    Inventor： KIANI-AZARBAYJANY ESMAIEL ,  LEPPER JAMES M JR ,  DIAB MOHAMED KHEIR

    IPC: A61B5/1455 ,  G01N21/35 ,  A61B5/00 ,  A61B5/145

    Abstract: A blood glucose monitoring system (100) is disclosed which provides for inducing an active pulse in the blood volume of a patient. The induction of an active pulse results in a cyclic, and periodic change in the flow of blood through a fleshy medium (310) under test. By actively inducing a change of the blood volume, modulation of the volume of blood can be obtained to provide a greater signal to noise ratio. This allows for the detection of constituents in blood at concentration leve ls below those previously detectable in a non-invasive system. Radiation which passes through the fleshy medium is detected by a detector (320) which generates a signal indicative of the intensity of the detected radiation. Signal processing is performed on the electrical signal to isolate those optical characteristics of the electrical signal due to the optical characteristics of the blood.

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