公开(公告)号：WO1995002358A1

公开(公告)日：1995-01-26

申请号：PCT/US1994007866

申请日：1994-07-13

Applicant: MASIMO CORPORATION

Inventor： MASIMO CORPORATION ,  BRANIGAN, Brendan ,  KIANI-AZARBAYJANY, Esmaiel

IPC: A61B05/00

CPC classification number: A61B5/6826 ,  A61B5/14552 ,  A61B5/6838 ,  G06Q20/18

Abstract: An oximetric sensor probe (21) is movably coupled to a patient's finger to facilitate transillumination and detection of optical energy through a portion of the patient's finger without subjecting the finger to significant deformation. The finger is received within a finger cot (22) having a cupshaped closed end (26) and an opposite open end (24) that is rolled up upon itself and is adapted to be unrolled longitudinally along the finger to form a tubular enclosure which closely surrounds the finger. An optical source (34) and an optical detector (36) are arranged in spaced axial alignment with each other on opposite sides of the finger so that optical energy transmitted by the source (34) through the finger is received by the detector (36). The detected light is analyzed to noninvasively determine the saturation of oxygen within the patient's blood. By virtue of the nonadhesive connection between the probe (21) and the finger, decoupling the optical path between the source (34) and detector (36) is minimized in the event that the patient moves his finger during testing. The optical source (34) and optical detector (36) also are separable from the finger cot (22) such that the optical sensor (23) may be reused with another finger cot.

Abstract translation: 血氧测量传感器探针（21）可移动地联接到患者的手指以便于透过患者手指的一部分的透照和检测光能，而不会使手指受到显着的变形。 手指被接收在具有杯形封闭端（26）和相对的开口端（24）的指状床（22）内，该开口端卷绕在自身上并且适于沿着手指纵向展开以形成密封的管状外壳 围着手指。 光源（34）和光学检测器（36）在手指的相对侧彼此间隔开地轴向对准布置，使得由源（34）通过手指传输的光能被检测器（36）接收， 。 分析检测到的光以非侵入性地确定患者血液中氧气的饱和度。 通过探头（21）和手指之间的无粘性连接，在患者在测试过程中移动手指的情况下，将源（34）和检测器（36）之间的光路去耦合最小化。 光源（34）和光学检测器（36）也可以与手指托（22）分离，使得光学传感器（23）可以用另一个手指托使用。

公开(公告)号：WO1996039926A1

公开(公告)日：1996-12-19

申请号：PCT/US1996008505

申请日：1996-06-04

Applicant: MASIMO CORPORATION

Inventor： MASIMO CORPORATION ,  KIANI-AZARBAYJANY, Esmaiel ,  DIAB, Mohamed, Kheir ,  LEPPER, James, M., Jr.

IPC: A61B05/00

CPC classification number: A61B5/14552 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/6826 ,  A61B5/6838 ,  A61B2560/0462 ,  G01N2021/1723

Abstract: A blood glucose monitoring system (100) is disclosed which provides for inducing an active pulse in the blood volume of a patient. The induction of an active pulse results in a cyclic, and periodic change in the flow of blood through a fleshy medium (310) under test. By actively inducing a change of the blood volume, modulation of the volume of blood can be obtained to provide a greater signal to noise ratio. This allows for the detection of constituents in blood at concentration levels below those previously detectable in a non-invasive system. Radiation which passes through the fleshy medium is detected by a detector (320) which generates a signal indicative of the intensity of the detected radiation. Signal processing is performed on the electrical signal to isolate those optical characteristics of the electrical signal due to the optical characteristics of the blood.

Abstract translation: 公开了一种血液葡萄糖监测系统（100），其提供在患者的血液体积中诱导活动脉冲。 激活脉冲的诱导导致血液通过被测试的肉质培养基（310）的循环和周期性变化。 通过积极地引起血液量的变化，可以获得血液体积的调节以提供更大的信噪比。 这允许以非侵入性系统中先前可检测的浓度水平检测血液中的成分。 通过肉质介质的辐射由检测器（320）检测，其产生指示检测到的辐射的强度的信号。 对电信号执行信号处理，以隔离由于血液的光学特性引起的电信号的这些光学特性。

公开(公告)号：WO1996041218A1

公开(公告)日：1996-12-19

申请号：PCT/US1996008627

申请日：1996-06-04

Applicant: MASIMO CORPORATION

Inventor： MASIMO CORPORATION ,  LEPPER, James, M., O., Jr. ,  DIAB, Mohamed, Kheir

IPC: G02B05/28

CPC classification number: G01N21/314 ,  G01J3/26 ,  G02B5/285

Abstract: An optical filter (120) used in applications involving spectroscopic measurements is fabricated by depositing layers (111) of optical coatings onto a substrate (110). The layers (111) are deposited so as to have a substantially constant thickness in a first direction along the surface of the substrate (110), and a gradually increasing thickness along a direction perpendicular to the first direction. The structure of the optical filter (120) allows for large scale production of the filter so that costs in producing the filter are greatly reduced. The filter (120) may be used in a variety of applications including, but not limited to chemical analysis, blood glucose monitoring, and the like.

Abstract translation: 通过将光学涂层的层（111）沉积到衬底（110）上来制造用于涉及光谱测量的应用中的光学滤光器（120）。 层（111）被沉积成沿着基板（110）的表面沿着第一方向具有基本恒定的厚度，并且沿垂直于第一方向的方向逐渐增加厚度。 滤光器（120）的结构允许大规模生产过滤器，从而大大降低了生产过滤器的成本。 过滤器（120）可以用于各种应用，包括但不限于化学分析，血糖监测等。

公开(公告)号：WO1996041138A1

公开(公告)日：1996-12-19

申请号：PCT/US1996008631

申请日：1996-06-04

Applicant: MASIMO CORPORATION

Inventor： MASIMO CORPORATION ,  DIAB, Mohamed, Kheir ,  KIANI-AZARBAYJANY, Esmaiel ,  RAGSDALE, Charles, Robert ,  LEPPER, James M, Jr.

IPC: G01J03/10

CPC classification number: A61B5/1495 ,  A61B5/0205 ,  A61B5/02427 ,  A61B5/14552 ,  A61B5/6826 ,  A61B5/6838 ,  A61B2562/08 ,  G01J3/02 ,  G01J3/0254 ,  G01J3/027 ,  G01J3/0275 ,  G01J3/0291 ,  G01J3/10 ,  G01J2003/2866 ,  G01N21/255 ,  G01N21/274 ,  G01N21/31 ,  G01N21/3151 ,  G01N21/39 ,  G01N2021/3144 ,  G01N2201/0627

Abstract: The method and apparatus of the present invention provides a system wherein light-emitting diodes (LEDs) (162) can be tuned within a given range by selecting their operating drive current in order to obtain a precise wavelength. The present invention further provides a manner in which to calibrate and utilize an LED probe (150), such that the shift in wavelength for a known change in drive current is a known quantity. In general, the principle of wavelength shift for current drive changes for LEDs is utilized in order to allow better calibration and added flexibility in the use of LED sensors, particularly in applications when the precise wavelength is needed in order to obtain accurate measurements. The present invention also provides a system in which it is not necessary to know precise wavelengths of LEDs where precise wavelengths were needed in the past. Finally, the present invention provides a method and apparatus for determining the operating wavelength of a light-emitting element such as a light-emitting diode.

Abstract translation: 本发明的方法和装置提供了一种系统，其中可以通过选择其工作驱动电流来在给定范围内调节发光二极管（LED）162以获得精确的波长。 本发明还提供了校准和利用LED探针（150）的方式，使得驱动电流已知变化的波长偏移是已知量。 通常，利用LED的电流驱动变化的波长偏移原理，以便在使用LED传感器时更好地进行校准和增加灵活性，特别是在需要精确波长以获得准确测量的应用中。 本发明还提供一种系统，其中不需要知道过去需要精确波长的LED的精确波长。 最后，本发明提供一种用于确定诸如发光二极管的发光元件的工作波长的方法和装置。

公开(公告)号：WO1996013208A1

公开(公告)日：1996-05-09

申请号：PCT/US1995014785

申请日：1995-11-01

Applicant: MASIMO CORPORATION

Inventor： MASIMO CORPORATION ,  DIAB, Mohamed, Kheir ,  KIANI-AZARBAYJANY, Esmaiel ,  LEPPER, James, E., Jr.

IPC: A61B05/00

CPC classification number: A61B5/14552 ,  A61B5/02427 ,  A61B5/6826 ,  A61B5/6829 ,  A61B5/6838 ,  A61B2562/08 ,  A61B2562/12 ,  H05K1/189

Abstract: An optical probe for measurements, which is particularly suited to reduce noise in measurements taken on an easily compressible material, such as a finger, a toe, a forehead, an earlobe, or a lip. The probe includes a base having an aperture which leads to a chamber. The base is placed adjacent a portion of the material, the chamber being placed directly adjacent any easily compressible portion of the material. A photodetector is located within the chamber and does not contact the material. A light emitting diode (LED) is affixed to the material, opposite the photodetector and above the chamber. The material which is supported by the aperture and therefore rests above or has intruded into the chamber is inhibited from compression since nothing comes in contact with this portion of the material, even when the material moves. Thus, light from the LED is directly through a stabilized portion of the material, i.e., the optical path length through which light travels is stabilized, even during motion of the material. This reduces noise in the signal measured by the photodetector. A scattering medium is interposed between the LED and the material, between the material and the photodetector, or between the LED and the material as well as between the material and the photodetector. The scattering medium is used to improve the signal-to-noise ratio of the received optical signal.

Abstract translation: 用于测量的光学探针，其特别适用于减少在容易压缩的材料（例如手指，脚趾，额头，耳垂或唇部）上进行的测量中的噪声。 探针包括具有通向腔室的孔的底座。 基部放置在材料的一部分附近，该腔被直接放置在材料的任何容易压缩的部分附近。 光电检测器位于室内并且不接触材料。 发光二极管（LED）固定在材料上，与光电检测器相对并且在腔室上方。 被孔支撑并且因此搁置在腔室中或已经入侵到腔室中的材料被抑制，因为即使当材料移动时也不会与材料的这一部分接触。 因此，即使在材料的运动期间，来自LED的光直接通过材料的稳定部分，即光行进的光路长度被稳定。 这降低了由光电检测器测量的信号中的噪声。 散射介质介于LED和材料之间，材料和光电检测器之间，或介于LED和材料之间以及材料与光电检测器之间。 散射介质用于提高接收到的光信号的信噪比。

公开(公告)号：WO1998056078A1

公开(公告)日：1998-12-10

申请号：PCT/US1998011067

申请日：1998-06-01

Applicant: MASIMO CORPORATION

Inventor： MASIMO CORPORATION ,  MILLS, Michael, A. ,  SMITH, Robert, A.

IPC: H01R13/658

CPC classification number: H01R13/6599 ,  Y10S439/939

Abstract: An electrical connector for a medical instrument has a plug containing a plurality of pins in electrical communication with wires emanating from a shielded cable that is connected to a medical sensor detecting physiological data. The plug portion of the electrical connector substantially surrounds the connection of the pins with the cable in a plastic housing. When the plug is inserted into a socket portion of the connector mounted to a medical instrument housing, the pins electrically communicate with a plurality of tubular sockets to communicate the signals to electronic devices in a medical instrument. Surface coatings on the connector are provided to shield the wire connections with the pins and tubular sockets from electromagnetic interference (EMI). A tubular shield is also provided in the medical instrument to shield the electrical connection between the internal cable and the tubular receptacles from EMI. The EMI shields on the connector and the EMI shielding on the connecting cables are all connected to a common ground. A significant reduction in EMI distortion of the sensor signals is achieved.

Abstract translation: 用于医疗器械的电连接器具有插塞，其包含多个引脚，其与从屏蔽电缆发出的电线电连通，该屏蔽电缆连接到检测生理数据的医疗传感器。 电连接器的插头部分基本上围绕塑料壳体中的销与电缆的连接。 当插头插入到安装到医疗器械外壳的连接器的插座部分中时，引脚与多个管状插座电连通以将信号传送到医疗器械中的电子设备。 提供连接器上的表面涂层以屏蔽具有销和管状插座的电线连接免受电磁干扰（EMI）。 医疗器械中还设置有管状屏蔽件，用于屏蔽内部电缆和管状插座之间的电气连接不受EMI影响。 连接器上的EMI屏蔽层和连接电缆上的EMI屏蔽都连接到公共地面。 实现传感器信号的EMI失真的显着降低。

公开(公告)号：WO1996041151A1

公开(公告)日：1996-12-19

申请号：PCT/US1996008506

申请日：1996-06-04

Applicant: MASIMO CORPORATION

Inventor： MASIMO CORPORATION ,  LEPPER, James, M., Jr. ,  DIAB, Mohamed, Kheir

IPC: G01N21/31

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  G01N21/31 ,  G02B26/008

Abstract: A blood glucose monitoring system (100) includes a broadband light source (110) and a specially fabricated optical filter (120) for modulating optical radiation to be transmitted through a fleshy medium. Optical radiation (125) which passes through the fleshy medium (130) is detected by an optical detector (140) which generates an electrical signal indicative of the intensity of the detected light. Digital signal processing is performed on the electrical signal to extract those optical characteristics of the electrical signal due to the optical characteristics of the filter and constituents of the fleshy medium other than blood glucose concentration. The monitoring system employs a unique "double-log" transformation to minimize errors due to indeterminate path length variations of the optical radiation through the fleshy medium. The monitoring system (100) further employs specialized signal processing to avoid inaccuracies due to the previously unidentified solvent effect which arises when glucose is dissolved into water.

Abstract translation: 血糖监测系统（100）包括宽带光源（110）和专门制造的光滤波器（120），用于调制通过肉质介质传输的光辐射。 通过肉质介质（130）的光辐射（125）由光学检测器（140）检测，该检测器产生指示检测到的光的强度的电信号。 对电信号进行数字信号处理，由于过滤器的光学特性和除了血糖浓度以外的肉质培养基的成分，提取电信号的这些光学特性。 监测系统采用独特的“双对数”变换，以通过肉肉培养基对光学辐射的不确定的路径长度变化来最小化误差。 监测系统（100）进一步采用专门的信号处理，以避免由于当葡萄糖溶解在水中时出现的先前未确定的溶剂效应引起的不准确。

公开(公告)号：WO1996012435A3

公开(公告)日：1996-05-02

申请号：PCT/US1995013469

申请日：1995-10-10

Applicant: MASIMO CORPORATION

Inventor： MASIMO CORPORATION ,  DIAB, Mohamed, Kheir ,  KIANI-AZARBAYJANY, Esmaiel ,  ELFADEL, Ibrahim, M. ,  MCCARTHY, Rex, John ,  WEBER, Walter, Michael ,  SMITH, Robert, A.

IPC: A61B05/00