公开(公告)号：JP2011137166A

公开(公告)日：2011-07-14

申请号：JP2011034116

申请日：2011-02-21

Applicant: Mayo Foundation For Medical Education & Research ,  メイヨ フオンデーシヨン フオー メデイカル エジユケーシヨン アンド リサーチ

Inventor： YASZEMSKI MICHAEL J ,  CURRIER BRADFORD L ,  JABBARI ESMAIEL ,  LU LICHUN

IPC: C08G63/08 ,  A61K20060101 ,  A61L24/00 ,  A61L27/00 ,  C08F290/00 ,  C08G63/91 ,  C08J9/26 ,  C08L101/16

CPC classification number: C08G63/08 ,  A61L24/0036 ,  A61L24/0042 ,  A61L24/0084 ,  A61L24/046 ,  A61L27/18 ,  A61L27/46 ,  A61L27/56 ,  A61L27/58 ,  A61L2430/02 ,  C08F290/00 ,  C08G63/60 ,  C08G63/912 ,  C08J9/26 ,  C08J2367/04 ,  C08K3/32 ,  C08L67/06 ,  C08L67/04

Abstract: PROBLEM TO BE SOLVED: To provide a poly(caprolactone-fumarate)polymer which is biocompatible, bioabsorbable, and injectable, and can be cured in situ to be useful for use in tissue engineering. SOLUTION: The crosslinkable, biodegradable, and biocompatible material comprises a dual copolymer which comprises a caprolactone constituent unit and a fumaric acid constituent unit. COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 要解决的问题：提供生物相容性，生物可吸收性和可注射性的聚（己内酯 - 富马酸酯）聚合物，并且可以原位固化以用于组织工程。 解决方案：可交联，可生物降解和生物相容的材料包括双共聚物，其包含己内酯构成单元和富马酸组成单元。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：AT511439T

公开(公告)日：2011-06-15

申请号：AT06751721

申请日：2006-04-28

Applicant: MAYO FOUNDATION

Inventor： WANG SHANFENG ,  LU LICHUN ,  YASZEMSKI MICHAEL

IPC: B29C67/20 ,  A61F2/00 ,  A61F2/20 ,  C08F8/02 ,  C08F20/00 ,  C08F22/00 ,  C08G63/02 ,  C08K3/32

公开(公告)号：AT464341T

公开(公告)日：2010-04-15

申请号：AT04777241

申请日：2004-06-29

Applicant: MAYO FOUNDATION

Inventor： YASZEMSKI MICHAEL ,  CURRIER BRADFORF ,  JABBARI ESMAIEL ,  LU LICHUN

IPC: C08J5/12 ,  A61F2/00 ,  A61F2/02 ,  A61F2/28 ,  A61L27/42

Abstract: A composition is disclosed which comprises (i) a macromer prepared by reacting an unsaturated diacid having a carbon-carbon double bond and a saturated diacid, and (ii) a bioactive ceramic grafted to the macromer. In one embodiment, the unsaturated diacid having a carbon-carbon double bond is fumaric acid, the saturated diacid is compatible with fumaric acid and poly(propylene fumarate) such as succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid and mixtures thereof, and the bioactive ceramic is hydroxyapatite. In another embodiment, hydroxyapatite is grafted with a biodegradable and crosslinkable macromer comprising silane units alternating with furnarate and adipate units.

公开(公告)号：ES2318339T3

公开(公告)日：2009-05-01

申请号：ES04782412

申请日：2004-08-27

Applicant: MAYO FOUNDATION

Inventor： JABBARI ESMAIEL ,  YASZEMSKI MICHAEL J ,  CURRIER BRADFORD L ,  LU LICHUN

IPC: C08J9/00 ,  A61F20060101 ,  A61L27/48 ,  A61L27/56 ,  A61L27/58 ,  C08K5/00

Abstract: Composición para la fabricación de una estructura porosa, cuya composición comprenda: un polímero no saturado biodegradable; un agente de reticulación; y un generador de poros de micropartículas de hidrogel biodegradable, en la que las micropartículas de hidrogel comprenden agua retenida.

公开(公告)号：AT416223T

公开(公告)日：2008-12-15

申请号：AT04782412

申请日：2004-08-27

Applicant: MAYO FOUNDATION

Inventor： JABBARI ESMAIEL ,  YASZEMSKI MICHAEL ,  CURRIER BRADFORD ,  LU LICHUN

IPC: C08J9/00 ,  A61F20060101 ,  A61L27/48 ,  A61L27/56 ,  A61L27/58 ,  C08K5/00

Abstract: Hydrogel microparticles with entrapped liquid are used as the porogen to reproducibly form interconnected pore networks in a porous scaffold. In one embodiment, a biodegradable unsaturated polymer, a crosslinking agent, and a porogen comprising biodegradable hydrogel microparticles are mixed together and allowed to form a porous scaffold in an mold or in a body cavity. Example biodegradable unsaturated polymers include poly(propylene fumarate) and poly(e-caprolactone-fumarate). The cosslinking agent may be a free radical initiator, or may include a free radical initiator and a monomer capable of addition polymerization. Example hydrogel microparticles include uncrosslinked or crosslinked collagen , an uncrosslinked or crosslinked collagen derivative, and an uncrosslinked or crosslinked synthetic biodegradable polymer such as oligo(poly(ethylene glycol) fumarate).

公开(公告)号：AU2006226923A1

公开(公告)日：2006-09-28

申请号：AU2006226923

申请日：2006-03-23

Applicant: MAYO FOUNDATION

Inventor： DADSETAN MAHROKH ,  YASZEMSKI MICHAEL ,  LU LICHUN

IPC: A61F2/00 ,  A61K31/79

Abstract: The invention provides photocrosslinkable, injectable, biodegradable oligo(poly(ethylene glycol) fumarate) (OPF) hydrogels made from the photopolymerization of an OPF macromer with UV light and a photoinitiator. Hydrogels with varying mechanical properties and water content can be made with changes in macromer and crosslinking agent concentration in a precursor solution. The biodegradable OPF hydrogels can be injected as a fluid into a bodily defect of any shape, may incorporate various therapeutic agents, e.g., cells and/or growth factors, and may be implanted via minimally invasive arthroscopic techniques.

公开(公告)号：AU2004268013A1

公开(公告)日：2005-03-10

申请号：AU2004268013

申请日：2004-08-27

Applicant: MAYO FOUNDATION

Inventor： YASZEMSKI MICHAEL J ,  CURRIER BRADFORD L ,  JABBARI ESMAIEL ,  LU LICHUN

IPC: C08J9/00 ,  A61F20060101 ,  A61L27/48 ,  A61L27/56 ,  A61L27/58 ,  C08K5/00

Abstract: Hydrogel microparticles with entrapped liquid are used as the porogen to reproducibly form interconnected pore networks in a porous scaffold. In one embodiment, a biodegradable unsaturated polymer, a crosslinking agent, and a porogen comprising biodegradable hydrogel microparticles are mixed together and allowed to form a porous scaffold in an mold or in a body cavity. Example biodegradable unsaturated polymers include poly(propylene fumarate) and poly(e-caprolactone-fumarate). The cosslinking agent may be a free radical initiator, or may include a free radical initiator and a monomer capable of addition polymerization. Example hydrogel microparticles include uncrosslinked or crosslinked collagen , an uncrosslinked or crosslinked collagen derivative, and an uncrosslinked or crosslinked synthetic biodegradable polymer such as oligo(poly(ethylene glycol) fumarate).

公开(公告)号：CA2588351A1

公开(公告)日：2006-05-26

申请号：CA2588351

申请日：2005-11-18

Applicant: MAYO FOUNDATION

Inventor： YASZEMSKI MICHAEL J ,  LU LICHUN ,  CURRIER BRADFORD L ,  WANG SHANGFENG

IPC: C08F20/00 ,  A61F2/00 ,  A61K31/77 ,  B32B27/00 ,  C08G63/02 ,  C08G65/332 ,  C08J9/26 ,  C08K3/32 ,  C12N5/06

公开(公告)号：AU2005306295A1

公开(公告)日：2006-05-26

申请号：AU2005306295

申请日：2005-11-18

Applicant: MAYO FOUNDATION

Inventor： WANG SHANGFENG ,  LU LICHUN ,  CURRIER BRADFORD L ,  YASZEMSKI MICHAEL J

IPC: C08G63/56

公开(公告)号：CA2588351C

公开(公告)日：2013-05-21

申请号：CA2588351

申请日：2005-11-18

Applicant: MAYO FOUNDATION

Inventor： WANG SHANGFENG ,  YASZEMSKI MICHAEL J ,  LU LICHUN ,  CURRIER BRADFORD L

IPC: C08G81/00 ,  A61L27/18 ,  C08G63/664 ,  C08J3/24 ,  C08L67/06 ,  C12N5/071

Abstract: Poly(propylene fumarate) is copolymerized with poly(caprolactone) diol to produce a block copolymer of poly(propylene fumarate) and poly(caprolactone). The biocompatible and bioresorbable block copolymer of poly(propylene fumarate) and poly(caprolactone) is useful in the fabrication of injectable and in~ situ hardening scaffolds for tissue and/or skeletal reconstruction. The block copolymer can be crosslinked by redox or photo-initiation, with or without an additional crosslinker. Thus, the copolymer is both self-crosslinkable (without the use of any crosslinkers) and photocrosslinkable (in the presence of photons such as UV light).