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公开(公告)号：JP2011137166A
公开(公告)日：2011-07-14
申请号：JP2011034116
申请日：2011-02-21
Applicant: Mayo Foundation For Medical Education & Research , メイヨ フオンデーシヨン フオー メデイカル エジユケーシヨン アンド リサーチ
Inventor： YASZEMSKI MICHAEL J , CURRIER BRADFORD L , JABBARI ESMAIEL , LU LICHUN
IPC: C08G63/08 , A61K20060101 , A61L24/00 , A61L27/00 , C08F290/00 , C08G63/91 , C08J9/26 , C08L101/16
CPC classification number: C08G63/08 , A61L24/0036 , A61L24/0042 , A61L24/0084 , A61L24/046 , A61L27/18 , A61L27/46 , A61L27/56 , A61L27/58 , A61L2430/02 , C08F290/00 , C08G63/60 , C08G63/912 , C08J9/26 , C08J2367/04 , C08K3/32 , C08L67/06 , C08L67/04
Abstract: PROBLEM TO BE SOLVED: To provide a poly(caprolactone-fumarate)polymer which is biocompatible, bioabsorbable, and injectable, and can be cured in situ to be useful for use in tissue engineering. SOLUTION: The crosslinkable, biodegradable, and biocompatible material comprises a dual copolymer which comprises a caprolactone constituent unit and a fumaric acid constituent unit. COPYRIGHT: (C)2011,JPO&INPIT
Abstract translation: 要解决的问题：提供生物相容性，生物可吸收性和可注射性的聚（己内酯 - 富马酸酯）聚合物，并且可以原位固化以用于组织工程。 解决方案：可交联，可生物降解和生物相容的材料包括双共聚物，其包含己内酯构成单元和富马酸组成单元。 版权所有（C）2011，JPO＆INPIT
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公开(公告)号：AT464341T
公开(公告)日：2010-04-15
申请号：AT04777241
申请日：2004-06-29
Applicant: MAYO FOUNDATION
Inventor： YASZEMSKI MICHAEL , CURRIER BRADFORF , JABBARI ESMAIEL , LU LICHUN
Abstract: A composition is disclosed which comprises (i) a macromer prepared by reacting an unsaturated diacid having a carbon-carbon double bond and a saturated diacid, and (ii) a bioactive ceramic grafted to the macromer. In one embodiment, the unsaturated diacid having a carbon-carbon double bond is fumaric acid, the saturated diacid is compatible with fumaric acid and poly(propylene fumarate) such as succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid and mixtures thereof, and the bioactive ceramic is hydroxyapatite. In another embodiment, hydroxyapatite is grafted with a biodegradable and crosslinkable macromer comprising silane units alternating with furnarate and adipate units.
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3.发明专利
公开(公告)号：ES2318339T3
公开(公告)日：2009-05-01
申请号：ES04782412
申请日：2004-08-27
Applicant: MAYO FOUNDATION
Inventor： JABBARI ESMAIEL , YASZEMSKI MICHAEL J , CURRIER BRADFORD L , LU LICHUN
Abstract: Composición para la fabricación de una estructura porosa, cuya composición comprenda: un polímero no saturado biodegradable; un agente de reticulación; y un generador de poros de micropartículas de hidrogel biodegradable, en la que las micropartículas de hidrogel comprenden agua retenida.
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公开(公告)号：AT416223T
公开(公告)日：2008-12-15
申请号：AT04782412
申请日：2004-08-27
Applicant: MAYO FOUNDATION
Inventor： JABBARI ESMAIEL , YASZEMSKI MICHAEL , CURRIER BRADFORD , LU LICHUN
Abstract: Hydrogel microparticles with entrapped liquid are used as the porogen to reproducibly form interconnected pore networks in a porous scaffold. In one embodiment, a biodegradable unsaturated polymer, a crosslinking agent, and a porogen comprising biodegradable hydrogel microparticles are mixed together and allowed to form a porous scaffold in an mold or in a body cavity. Example biodegradable unsaturated polymers include poly(propylene fumarate) and poly(e-caprolactone-fumarate). The cosslinking agent may be a free radical initiator, or may include a free radical initiator and a monomer capable of addition polymerization. Example hydrogel microparticles include uncrosslinked or crosslinked collagen , an uncrosslinked or crosslinked collagen derivative, and an uncrosslinked or crosslinked synthetic biodegradable polymer such as oligo(poly(ethylene glycol) fumarate).
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公开(公告)号：AU2004268013A1
公开(公告)日：2005-03-10
申请号：AU2004268013
申请日：2004-08-27
Applicant: MAYO FOUNDATION
Inventor： YASZEMSKI MICHAEL J , CURRIER BRADFORD L , JABBARI ESMAIEL , LU LICHUN
Abstract: Hydrogel microparticles with entrapped liquid are used as the porogen to reproducibly form interconnected pore networks in a porous scaffold. In one embodiment, a biodegradable unsaturated polymer, a crosslinking agent, and a porogen comprising biodegradable hydrogel microparticles are mixed together and allowed to form a porous scaffold in an mold or in a body cavity. Example biodegradable unsaturated polymers include poly(propylene fumarate) and poly(e-caprolactone-fumarate). The cosslinking agent may be a free radical initiator, or may include a free radical initiator and a monomer capable of addition polymerization. Example hydrogel microparticles include uncrosslinked or crosslinked collagen , an uncrosslinked or crosslinked collagen derivative, and an uncrosslinked or crosslinked synthetic biodegradable polymer such as oligo(poly(ethylene glycol) fumarate).
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Patent Agency Ranking
公开(公告)号：DE602004018163D1
公开(公告)日：2009-01-15
申请号：DE602004018163
申请日：2004-08-27
Applicant: MAYO FOUNDATION
Inventor： JABBARI ESMAIEL , YASZEMSKI MICHAEL J , CURRIER BRADFORD L , LU LICHUN
Abstract: Hydrogel microparticles with entrapped liquid are used as the porogen to reproducibly form interconnected pore networks in a porous scaffold. In one embodiment, a biodegradable unsaturated polymer, a crosslinking agent, and a porogen comprising biodegradable hydrogel microparticles are mixed together and allowed to form a porous scaffold in an mold or in a body cavity. Example biodegradable unsaturated polymers include poly(propylene fumarate) and poly(e-caprolactone-fumarate). The cosslinking agent may be a free radical initiator, or may include a free radical initiator and a monomer capable of addition polymerization. Example hydrogel microparticles include uncrosslinked or crosslinked collagen , an uncrosslinked or crosslinked collagen derivative, and an uncrosslinked or crosslinked synthetic biodegradable polymer such as oligo(poly(ethylene glycol) fumarate).
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公开(公告)号：CA2535857A1
公开(公告)日：2005-03-10
申请号：CA2535857
申请日：2004-08-27
Applicant: MAYO FOUNDATION
Inventor： YASZEMSKI MICHAEL J , LU LICHUN , CURRIER BRADFORD L , JABBARI ESMAIEL
Abstract: Hydrogel microparticles with entrapped liquid are used as the porogen to reproducibly form interconnected pore networks in a porous scaffold. In one embodiment, a biodegradable unsaturated polymer, a crosslinking agent, and a porogen comprising biodegradable hydrogel microparticles are mixed together and allowed to form a porous scaffold in an mold or in a body cavity. Exampl e biodegradable unsaturated polymers include poly(propylene fumarate) and poly(.epsilon.-caprolactone-fumarate). The crosslinking agent may be a free radical initiator, or may include a free radical initiator and a monomer capable of addition polymerization. Example hydrogel microparticles include uncrosslinked or crosslinked collagen , an uncrosslinked or crosslinked collagen derivative, and an uncrosslinked or crosslinked synthetic biodegradable polymer such as oligo(poly(ethylene glycol) fumarate).
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公开(公告)号：AU2004267349A1
公开(公告)日：2005-03-03
申请号：AU2004267349
申请日：2004-06-29
Applicant: MAYO FOUNDATION
Inventor： CURRIER BRADFORF L , LU LICHUN , YASZEMSKI MICHAEL J , JABBARI ESMAIEL
Abstract: A composition is disclosed which comprises (i) a macromer prepared by reacting an unsaturated diacid having a carbon-carbon double bond and a saturated diacid, and (ii) a bioactive ceramic grafted to the macromer. In one embodiment, the unsaturated diacid having a carbon-carbon double bond is fumaric acid, the saturated diacid is compatible with fumaric acid and poly(propylene fumarate) such as succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid and mixtures thereof, and the bioactive ceramic is hydroxyapatite. In another embodiment, hydroxyapatite is grafted with a biodegradable and crosslinkable macromer comprising silane units alternating with furnarate and adipate units.
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9.发明专利
公开(公告)号：ES2345108T3
公开(公告)日：2010-09-15
申请号：ES04777241
申请日：2004-06-29
Applicant: MAYO FOUNDATION
Inventor： YASZEMSKI MICHAEL J , CURRIER BRADFORF L , JABBARI ESMAIEL , LU LICHUN
Abstract: Una composición que comprende: un macrómero que incluye unidades de silano, unidades derivadas de un diácido insaturado que cuenta con un doble enlace carbono-carbono, y unidades derivadas de un diácido saturado; y un componente cerámico bioactivo injertado al macrómero.
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公开(公告)号：DE602004026593D1
公开(公告)日：2010-05-27
申请号：DE602004026593
申请日：2004-06-29
Applicant: MAYO FOUNDATION
Inventor： YASZEMSKI MICHAEL J , CURRIER BRADFORF L , JABBARI ESMAIEL , LU LICHUN
Abstract: A composition is disclosed which comprises (i) a macromer prepared by reacting an unsaturated diacid having a carbon-carbon double bond and a saturated diacid, and (ii) a bioactive ceramic grafted to the macromer. In one embodiment, the unsaturated diacid having a carbon-carbon double bond is fumaric acid, the saturated diacid is compatible with fumaric acid and poly(propylene fumarate) such as succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid and mixtures thereof, and the bioactive ceramic is hydroxyapatite. In another embodiment, hydroxyapatite is grafted with a biodegradable and crosslinkable macromer comprising silane units alternating with furnarate and adipate units.
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