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1.发明申请VIVIT POLYPEPTIDES, THERAPEUTIC AGENT COMPRISING THE SAME, AND METHOD OF SCREENING FOR ANTI-CANCER AGENT 审中-公开VIVIT POLYPEPTIDES，包括其的治疗药物以及用于抗癌剂的筛选方法
公开(公告)号：WO2007013358A3
公开(公告)日：2007-07-05
申请号：PCT/JP2006314442
申请日：2006-07-14
Applicant: ONCOTHERAPY SCIENCE INC , UNIV TOKYO , NAKAMURA YUSUKE , KATAGIRI TOYOMASA , INAKI KOICHIRO
Inventor： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , INAKI KOICHIRO
CPC classification number: G01N33/57438 , A61K38/08 , A61K38/10 , A61K38/1709 , C07K14/47 , G01N33/5011 , G01N33/6893 , G01N2500/00
Abstract: The present invention provides polypeptides useful for treating and preventing cancer. The present invention also provides therapeutic agents or methods for treating cancer using the polypeptides. The polypeptides of the present invention are composed of an amino acid sequence which comprises VIVIT and is preferably a polypeptide in which the motif sequence PxIxIT at positions 37 to 41 of the amino acid sequence of the C1958 protein (SEQ ID NO: 2) is replaced with PVIVIT. The polypeptides of the present invention can be introduced into cancer cells by modifying the polypeptides with transfection agents such as poly-arginine. The present invention provides methods and kits for identifying inhibitors of the interaction between C1958 and PPP3CA which find utility in the treatment and prevention of cancer. Also disclosed herein are compositions for treating or preventing cancer identified by the screening method of the present invention and methods of using same in the treatment and prevention of cancer.
Abstract translation: 本发明提供了可用于治疗和预防癌症的多肽。 本发明还提供了使用多肽治疗癌症的治疗剂或方法。 本发明的多肽由包含VIVIT的氨基酸序列组成，优选其中C1958蛋白（SEQ ID NO：2）的氨基酸序列的第37至41位上的基序序列PxIxIT被替换的多肽 与PVIVIT。 本发明的多肽可以通过用转染试剂例如聚精氨酸修饰多肽而被引入到癌细胞中。 本发明提供用于鉴定C1958和PPP3CA之间相互作用的抑制剂的方法和试剂盒，其可用于治疗和预防癌症。 本文还公开了用于治疗或预防由本发明的筛选方法鉴定的癌症的组合物及其在治疗和预防癌症中的使用方法。
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2.发明申请HYPOXIA-INDUCIBLE PROTEIN 2 (HIG2), A NOVEL THERAPEUTIC POTENTIAL TARGET OF RENAL CELL CARCINOMA (RCC) 审中-公开低氧诱导蛋白2（HIG2）是肾细胞癌（RCC）的一种新的治疗潜在靶点
公开(公告)号：WO2005019475A3
公开(公告)日：2005-08-11
申请号：PCT/JP2004012411
申请日：2004-08-20
Applicant: ONCOTHERAPY SCIENCE INC , UNIV TOKYO , NAKAMURA YUSUKE , KATAGIRI TOYOMASA
Inventor： NAKAMURA YUSUKE , KATAGIRI TOYOMASA
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/136 , C12Q2600/158
Abstract: The present invention provides a method for inhibiting growth of a cancer cell, particularly a renal cell carcinoma, by contacting the cell with a composition composed of an HIG2 siRNA or HIG2 antibody. Methods of diagnosing renal cell cancer are also provided within the present invention.
Abstract translation: 本发明提供通过使细胞与由HIG2 siRNA或HIG2抗体组成的组合物接触来抑制癌细胞，特别是肾细胞癌生长的方法。 本发明还提供了诊断肾细胞癌的方法。
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公开(公告)号：WO2006016525A3
公开(公告)日：2006-07-06
申请号：PCT/JP2005014369
申请日：2005-07-29
Applicant: ONCOTHERAPY SCIENCE INC , UNIV TOKYO , NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
Inventor： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
CPC classification number: C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
Abstract: The present application provides novel human genes B1194, A2282V1, A2282V2, and A2282V3 whose expression is markedly elevated in breast cancer. These genes and polypeptides encoded thereby can be used, for example, in the diagnosis of breast cancer, and as target molecules for developing drugs against breast cancer.
Abstract translation: 本申请提供了在乳腺癌中表达显着升高的新型人基因B1194，A2282V1，A2282V2和A2282V3。 由此编码的这些基因和多肽可用于例如乳腺癌的诊断，以及用于开发针对乳腺癌的药物的靶分子。
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公开(公告)号：WO2004031231A3
公开(公告)日：2004-07-08
申请号：PCT/JP0312074
申请日：2003-09-22
Applicant: ONCOTHERAPY SCIENCE INC , JAPAN AS REPRESENTED BY THE PR , NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKAGAWA HIDEWAKI , NAKATSURU SHUICHI
Inventor： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKAGAWA HIDEWAKI , NAKATSURU SHUICHI
CPC classification number: C07K14/47 , C12Q1/6886 , C12Q2600/136
Abstract: The present application provides novel human gene MICAL2-PV whose expression is markedly elevated in prostate cancers. Furthermore, it provides polypeptides encoded by the gene as well as polypeptides encoded by PCOTH which expression was also discovered to be elevated in prostate cancers. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of prostate cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of prostate cancer.
Abstract translation: 本申请提供了新型人基因MICAL2-PV，其表达在前列腺癌中显着升高。 此外，它提供由该基因编码的多肽以及由PCOTH编码的多肽，其表达也被发现在前列腺癌中升高。 由该基因编码的基因和多肽可以用于例如前列腺癌的诊断中，作为用于开发针对该疾病的药物的靶分子，以及用于减轻前列腺癌的细胞生长。
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公开(公告)号：WO2004031409A3
公开(公告)日：2005-02-24
申请号：PCT/JP0310256
申请日：2003-08-12
Applicant: ONCOTHERAPY SCIENCE INC , JAPAN AS REPRESENTED BY THE PR , NAKAMURA YUSUKE , KATAGIRI TOYOMASA
Inventor： NAKAMURA YUSUKE , KATAGIRI TOYOMASA
CPC classification number: C12Q1/6883 , A61K39/0011 , C07K14/47 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57426 , G01N2500/04
Abstract: Objective methods for detecting and diagnosing Chronic myeloid leukemia (CML) are described herein. In one embodiment, the diagnostic method involves the determining a expression level of CML-associated gene that discriminate between CML and nomal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of CML, methods of treating CML and method of vaccinating a subject against CML.
Abstract translation: 本文描述了用于检测和诊断慢性骨髓性白血病（CML）的客观方法。 在一个实施方案中，诊断方法涉及确定区分CML和正常细胞的CML相关基因的表达水平。 本发明进一步提供筛选用于治疗CML的治疗剂，CML治疗方法以及针对CML接种受试者的方法。
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Patent Agency Ranking
公开(公告)号：WO2004031412A3
公开(公告)日：2004-07-15
申请号：PCT/JP0311817
申请日：2003-09-17
Applicant: ONCOTHERAPY SCIENCE INC , JAPAN AS REPRESENTED BY THE PR , NAKAMURA YUSUKE , KATAGIRI TOYOMASA
Inventor： NAKAMURA YUSUKE , KATAGIRI TOYOMASA
IPC: A61K38/00 , C07K14/47 , C12Q1/68 , G01N33/574
CPC classification number: G01N33/57438 , A61K38/00 , C07K14/47 , C07K14/82 , C12Q1/6837 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , Y02A90/26
Abstract: Objective methods for detecting and diagnosing pancreatic cancer (PNC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of PNC-associated gene that discriminates between PNC cells and normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of pancreatic cancer, methods of treating pancreatic cancer and method of vaccinating a subject against pancreatic cancer.
Abstract translation: 本文描述了用于检测和诊断胰腺癌（PNC）的客观方法。 在一个实施方案中，诊断方法涉及确定区分PNC细胞和正常细胞的PNC相关基因的表达水平。 本发明进一步提供筛选用于治疗胰腺癌的治疗剂的方法，治疗胰腺癌的方法以及针对胰腺癌接种受试者的方法。
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公开(公告)号：CA2655289C
公开(公告)日：2016-08-23
申请号：CA2655289
申请日：2006-08-24
Applicant: ONCOTHERAPY SCIENCE INC
Inventor： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI , ENDO KEIGO , KUHARA MOTOKI , YAGI KASUMI
IPC: C07K16/30 , A61K39/395
Abstract: The present invention relates to an antibody or a fragment thereof which is capable of binding to a Frizzled homologue 10 (FZD10) protein, such as a mouse monoclonal antibody, a chimeric antibody and a humanized antibody. Also, the present invention relates to a method for treating and/or preventing FZD10-associated disease; a method for diagnosis or prognosis of FZD10-associated disease; and a method for in vivo imaging of FZD10 in a subject.
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公开(公告)号：AT545658T
公开(公告)日：2012-03-15
申请号：AT04713982
申请日：2004-02-24
Applicant: ONCOTHERAPY SCIENCE INC
Inventor： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , KUHARA MOTOKI
IPC: C07K16/28 , A61K39/395 , A61P35/00 , C07K16/30 , C12Q1/68 , G01N33/574 , G01N33/577
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公开(公告)号：SG174071A1
公开(公告)日：2011-09-29
申请号：SG2011057932
申请日：2007-08-10
Applicant: ONCOTHERAPY SCIENCE INC
Inventor： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
Abstract: GENES AND POLYPEPTIDES RELATING TO BREAST CANCERSAbstractThe present application provides novel human genes A7322, whose expression is markedly elevated in breast cancer. The present application also provides human genes F3374 whose expression is markedly elevated in breast cancer. Thesegenes and polypeptides encoded thereby can be used, for example. in the diagnosis of breast cancer, and as target molecules for developing drugs against breast cancer. The invention features methods of screening for modulators of the kinase activity of PBK/TOPK. The invention further provides methods of screening for agents to prevent or treat cancer, such as breast cancer.(No suitable figure)
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公开(公告)号：AT505561T
公开(公告)日：2011-04-15
申请号：AT06782210
申请日：2006-07-26
Applicant: ONCOTHERAPY SCIENCE INC
Inventor： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
IPC: C12Q1/68
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