公开(公告)号：CA2655289C

公开(公告)日：2016-08-23

申请号：CA2655289

申请日：2006-08-24

Applicant: ONCOTHERAPY SCIENCE INC

Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA ,  NAKATSURU SHUICHI ,  ENDO KEIGO ,  KUHARA MOTOKI ,  YAGI KASUMI

IPC: C07K16/30 ,  A61K39/395

Abstract: The present invention relates to an antibody or a fragment thereof which is capable of binding to a Frizzled homologue 10 (FZD10) protein, such as a mouse monoclonal antibody, a chimeric antibody and a humanized antibody. Also, the present invention relates to a method for treating and/or preventing FZD10-associated disease; a method for diagnosis or prognosis of FZD10-associated disease; and a method for in vivo imaging of FZD10 in a subject.

公开(公告)号：ES2405618T3

公开(公告)日：2013-05-31

申请号：ES06783136

申请日：2006-08-24

Applicant: ONCOTHERAPY SCIENCE INC

Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA ,  NAKATSURU SHUICHI ,  ENDO KEIGO ,  KUHARA MOTOKI ,  YAGI KASUMI

IPC: C07K16/30 ,  A61K39/395

Abstract: Un anticuerpo quimérico o humanizado o fragmento del mismo que se une a la proteína FZD10 y en el quelas regiones determinantes de complementariedad (CDR) y las CDR del anticuerpo monoclonal de ratón 92-13(FERM BP-10628).