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    REAL-TIME REDOX SEQUENCING
    1.
    发明申请
    REAL-TIME REDOX SEQUENCING 审中-公开
    实时REDOX测序

    公开(公告)号：WO2013056241A3

    公开(公告)日：2013-06-20

    申请号：PCT/US2012060275

    申请日：2012-10-15

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA

    Inventor： KORLACH JONAS ,  TURNER STEPHEN ,  SUN LEI

    IPC: C12Q1/68 ,  C12Q1/48 ,  G01N27/26

    CPC classification number: C12Q1/6869 ,  B82Y15/00 ,  C12Q1/001 ,  C12Q2521/543 ,  C12Q2563/113 ,  C12Q2565/607 ,  C40B60/10 ,  G01N27/00 ,  G01N27/3277 ,  G01N27/3278 ,  C12Q2563/155

    Abstract: Real time redox sequencing methods, devices, and systems are described. Arrays of redox devices comprising one or two electrodes are used to provide sequence information about a template nucleic acid in a polymerase-template complex bound proximate to the electrode(s). A sequencing reaction mixture comprising nucleotide analogs comprising redox labels is introduced to the array of redox devices under conditions of polymerase mediated nucleic acid synthesis. The time sequence of incorporation of nucleotide analogs is determined by electrochemically identifying the redox labels of the nucleotide analogs that are incorporated into the growing strand.

    Abstract translation: 描述了实时氧化还原测序方法，设备和系统。 使用包含一个或两个电极的氧化还原装置的阵列来提供关于靠近电极的聚合酶 - 模板复合物中的模板核酸的序列信息。 将包含氧化还原标记的核苷酸类似物的测序反应混合物在聚合酶介导的核酸合成的条件下引入到氧化还原装置阵列中。 通过电化学鉴定掺入生长链中的核苷酸类似物的氧化还原标记来确定核苷酸类似物的掺入时间序列。

    SUBSTRATES, SYSTEMS AND METHODS FOR ANALYZING MATERIALS
    3.
    发明申请
    SUBSTRATES, SYSTEMS AND METHODS FOR ANALYZING MATERIALS 审中-公开
    用于分析材料的基板，系统和方法

    公开(公告)号：WO2008028160A3

    公开(公告)日：2008-11-06

    申请号：PCT/US2007077454

    申请日：2007-08-31

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA ,  LUNDQUIST PAUL ,  TURNER STEPHEN

    Inventor： LUNDQUIST PAUL ,  TURNER STEPHEN

    IPC: F21V9/16

    CPC classification number: G01N21/648 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/7703 ,  G01N2021/7786 ,  G02B6/43

    Abstract: Substrates, systems and methods for analyzing materials that include waveguide arrays disposed upon or within the substrate such that evanescent fields emanating from the waveguides illuminate materials disposed upon or proximal to the surface of the substrate, permitting analysis of such materials. The substrates, systems and methods are used in a variety of analytical operations, including, inter alia, nucleic acid analysis, including hybridization and sequencing analyses, cellular analyses and other molecular analyses.

    Abstract translation: 用于分析材料的衬底，系统和方法，其包括设置在衬底上或衬底内的波导阵列，使得从波导发出的消逝场照射设置在衬底表面上或其附近的材料，从而允许分析这些材料。 底物，系统和方法用于各种分析操作，包括核酸分析，包括杂交和测序分析，细胞分析和其他分子分析。

    SINGLE-MOLECULE REAL-TIME ANALYSIS OF PROTEIN SYNTHESIS
    5.
    发明申请
    SINGLE-MOLECULE REAL-TIME ANALYSIS OF PROTEIN SYNTHESIS 审中-公开
    单分子实时分析蛋白质合成

    公开(公告)号：WO2010144151A3

    公开(公告)日：2011-05-12

    申请号：PCT/US2010001692

    申请日：2010-06-11

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA ,  FLUSBERG BENJAMIN ,  TURNER STEPHEN ,  KORLACH JONAS ,  SCHADT ERIC

    Inventor： FLUSBERG BENJAMIN ,  TURNER STEPHEN ,  KORLACH JONAS ,  SCHADT ERIC

    IPC: C12Q1/68

    CPC classification number: G01N33/542 ,  G01N33/6818 ,  Y10T436/13 ,  Y10T436/143333

    Abstract: The present invention is generally directed to compositions, methods, and systems for performing single-molecule, real-time analysis of analytical reactions in which protein synthesis is occurring. The ability to analyze such reactions provides an opportunity to study those reactions as well as to potentially identify factors and/or approaches for impacting such reactions, e.g., to either enhance, inhibit, or otherwise affect such reactions including, but not limited to, affecting the reaction rate, processivity, fidelity, duration, and the like.

    Abstract translation: 本发明一般涉及用于进行蛋白质合成发生的分析反应的单分子实时分析的组合物，方法和系统。 分析这些反应的能力提供了研究这些反应的机会，并且潜在地鉴定影响这些反应的因素和/或方法，例如增强，抑制或以其他方式影响这些反应，包括但不限于影响 反应速度，持续性，持续时间等。

    MOLECULAR REDUNDANT SEQUENCING
    7.
    发明申请
    MOLECULAR REDUNDANT SEQUENCING 审中-公开
    分子冗余序列

    公开(公告)号：WO2009017678A2

    公开(公告)日：2009-02-05

    申请号：PCT/US2008009064

    申请日：2008-07-25

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA ,  CHRISTIANS FRED ,  TURNER STEPHEN

    Inventor： CHRISTIANS FRED ,  TURNER STEPHEN

    IPC: C12Q1/68 ,  C07H21/02

    CPC classification number: C12Q1/6869

    Abstract: Methods, systems and compositions where a target nucleic acid includes a registration sequence disposed therein for identification of the number or relative position of determined sequence from the template sequence. Particularly preferred aspects include a registration sequence in a circular template nucleic acid sequence which is, in turn, used in sequence by incorporation processes that rely upon template dependent, polymerase mediated primer extension in the identification of the sequence of the template.

    Abstract translation: 其中靶核酸包含置于其中的登记序列的方法，系统和组合物用于鉴定来自模板序列的确定序列的数目或相对位置。 特别优选的方面包括环形模板核酸序列中的配准序列，其依次通过依赖于模板依赖性，聚合酶介导的引物延伸在模板序列的鉴定中的掺入方法顺序使用。

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